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Journals / Harran Üniversitesi Veteriner Fakültesi Dergisi / 2018 / Cilt: 7 - Sayı: 1

Effect of High Carbohydrate, Fat and Intermittent Fasting Diet on Experimental Ulcerative Colitis

Deneysel Ülseratif Kolit Üzerine Yüksek Karbonhidratlı, Yüksek Yağlı ve Aralıklı Beslemenin Etkisi

Ahmet UYAR
Hüseyin EMLİK
Turan YAMAN
Pages
7–14
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a result, it was concluded that intermittent feeding administration in the colitis model had positive effects.

📌 3 Key Takeaways

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Objective & Hypothesis:In this study, it was aimed to comparatively investigate the effect of diet type and feeding frequency on occurence of experimental ulcerative colitis (UC), in Wistar albino rats.
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Key Findings & Data:For this purpose, 7 rats were randomly selected and 6 groups were formed as Control (n=7), Colitis (n=7), Colitis-High Carbohydrate Diet (C-HCD) (n=7), Colitis - High Carbohydrate Diet with Intermittent Feeding (C-HCIFD) (n=7), Colitis -High Fat Diet (C-HFD) (n=7), Colitis-High Fat Diet with Intermittent Feeding (C-HFIFD) (n=7).
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Conclusion & Impact:As a result, it was concluded that intermittent feeding administration in the colitis model had positive effects.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Yüksek Karbonhidratlı · Yağlı ve Aralıklı Diyet · Kolit

Abstract

In this study, it was aimed to comparatively investigate the effect of diet type and feeding frequency on occurence of experimental ulcerative colitis (UC), in Wistar albino rats. For this purpose, 7 rats were randomly selected and 6 groups were formed as Control (n=7), Colitis (n=7), Colitis-High Carbohydrate Diet (C-HCD) (n=7), Colitis - High Carbohydrate Diet with Intermittent Feeding (C-HCIFD) (n=7), Colitis -High Fat Diet (C-HFD) (n=7), Colitis-High Fat Diet with Intermittent Feeding (C-HFIFD) (n=7). In intermittent feeding groups the feeding was interrupted twice in a week for 24 hours . After 7 weeks of feeding, experimental colitis model was induced in colitis and treatment groups rats by intrarectal administration of acetic acid (pH 2.4, 4 %). After the 72 hours rats were sacrificed and colon samples were taken into 10% formalin solution. Histopathological studies have shown that acetic acid caused severe colitis damage, whereas the damage remained at minimal levels in groups with intermittent feeding. As a result, it was concluded that intermittent feeding administration in the colitis model had positive effects.

Özet

Bu çalışmada, dünyada görülme sıklığı artan inflamatuvar bağırsak hastalıklarının (İBH) bir tanesi olan Ülseratif kolit (ÜK) hastalığının Wistar albino türü ratlarda deneysel oluşumu üzerine beslenme şekli ve sıklığının karşılaştırmalı olarak araştırılması amaçlanmıştır. Bu amaçla; Kontrol (n=7), Kolit (n=7), Kolit-Yüksek Karbonhidratlı Diyet (K-YKD) (n=7), Kolit–Yüksek Karbonhidratlı Aralıklı Diyet (K-YKAD) (n=7), Kolit–Yüksek Yağlı Diyet (K-YYD) (n=7), Kolit-Yüksek Yağlı Aralıklı Diyet (K-YYAD) (n=7) olacak şekilde çalışma grupları oluşturuldu. Gruplardan aralıklı besleme gruplarına haftada sadece 2 gün (ardarda olmayan) diyet verilmesine 24 saat ara verildi. 7 haftalık beslemeden sonra deneysel kolit modeli; kolit ve tedavi gruplarındaki (Kolit, K-YKD, K-YKAD, K-YYD, K-YYAD) ratlara anestezi altında 30o trendelenburg pozisyonunda 8 mm’lik kateterin rektal yoldan 8 cm ileriye asetik asidin (pH 2.4, % 4) intrarektal (i.r.) olarak uygulanması ile oluşturuldu. 72 saat sonra ratlar sakrifiye edilerek histopatolojik örnekler %10 tamponlu formaldehite alındı. Histopatolojik incelemelere göre asetik asitin ciddi kolit hasarlarına neden olduğu buna karşın aralıklı olarak verilen diyet gruplarında bu hasarların oldukça minimal düzeyde kaldığı görülmüştür. Sonuç olarak kolit modelinde aralıklı diyet uygulamasının olumlu etkileri olduğu kanısına varıldı.

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Cite This Article

UYAR, A., EMLİK, H., YAMAN, T. (2022). Effect of High Carbohydrate, Fat and Intermittent Fasting Diet on Experimental Ulcerative Colitis. Harran Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 7 - Sayı: 1, 7–14. https://ajindex.com/articles/534254

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