Journals / Göztepe Tıp Dergisi / 2003 / Cilt: 18 - Sayı: 3

Comparison of acetazolamide given orally to dorzolamide given topically for intraoperatuar and postoperatuar lowering effect in cataract surgery

Katarakt cerrahisinde intraoperatif ve postoperatif göziçi basıncı kontrolünde oral asetazolamid ile topikal dorzolamidin karşılaştırılması

Pages
161–162
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

There was not statistically meaningful difference between topical dorzolamide group and oral acetazolamide group for the intra ocular pressure lowering effect.

📌 3 Key Takeaways

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Objective & Hypothesis:In this study we compared the effect of oral acetazolamide to topicale dorzolamide given preoperatively, for intraoperative and postoperative intra ocular pressure regulation.Between December 1998 and February 1999, 52 of 105 patients were medicated by acetazolamide given orally and 53 of them were medicated by dorzolamide applied topically before the operations.
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Key Findings & Data:Mean preoperative intra ocular pressure of 53 patients without medical therapy that were given topical dorzolamide was 12.5 mmHg, after medical therapy it was 10.8 mmHg.
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Conclusion & Impact:There was not statistically meaningful difference between topical dorzolamide group and oral acetazolamide group for the intra ocular pressure lowering effect.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In this study we compared the effect of oral acetazolamide to topicale dorzolamide given preoperatively, for intraoperative and postoperative intra ocular pressure regulation.Between December 1998 and February 1999, 52 of 105 patients were medicated by acetazolamide given orally and 53 of them were medicated by dorzolamide applied topically before the operations. Intra ocular pressures were measured by applanation tonometry with and without medication preoperatively and on the first postoperative day after the cataract operation. The results were compared. Mean preoperative intra ocular pressure of 53 patients without medical therapy that were given topical dorzolamide was 12.5 mmHg, after medical therapy it was 10.8 mmHg. Mean intra ocular pressure on the first postoperative day was 11.7 mmHg. Mean intra ocular pressure without medical therapy preoperatively for 52 patients that were given oral acetazolamide was 12.9 mmHg, after the medication it was 9.6 mmHg and intra ocular pressure on the first postoperative day it was 11.2 mmHg. There was not statistically meaningful difference between topical dorzolamide group and oral acetazolamide group for the intra ocular pressure lowering effect.

Özet

Çalışmamız, katarakt cerrahisinde preoperatif olarak kullanılan, oral asetozolamid ile topikal dorzolamid'in, intra ve postoperatif göziçi basıncına etkilerini karşılaştırmak amacı ile yapıldı.Aralık 1998 ile Şubat 1999 tarihleri arasında katarakt operasyonu amacı ile kliniğimize yatan 105 hastanın, 53'üne topikal dorzolamid, 52'sine oral asetazolamid preoperatif verilerek ilaçsız ve ilaçlı olarak preoperatif göziçi basınçları, Goldman applanasyon tonometresi ile ve postoperatif 1. gün göziçi basınçları yine aynı yöntemle ölçülerek etkinlikleri karşılaştırıldı. Topikal dorzolamid verilen 53 hastanın preoperatif ilaçsız göziçi basınç ortalaması 12.5 mmHg, preoperatif ilaçlı göziçi basıncı ortalaması 10.8 mmHg, postoperatif 1. gün göziçi basınç ortalaması 11.7 mmHg olarak bulundu. Oral asetazolamid verilen 52 hastanın preoperatif ilaçsız göziçi basınç ortalaması 12.9 mmHg, preoperatif ilaçlı göziçi basıncı ortalaması 9.6 mmHg, postoperatif 1. gün göziçi basınç ortalaması 11.2 mmHg olarak bulundu. Yapılan değerlendirme sonucu, her iki grup arasında, göziçi basıncını düşürmek açısından anlamlı bir fark bulunamadı.

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Cite This Article

İBİŞ, Ö., MESÇİ, C., HOROZ, H., ERBİL, H., ŞEN, V. (2022). Comparison of acetazolamide given orally to dorzolamide given topically for intraoperatuar and postoperatuar lowering effect in cataract surgery. Göztepe Tıp Dergisi, Cilt: 18 - Sayı: 3, 161–162. https://ajindex.com/articles/526487

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