Journals / Göztepe Tıp Dergisi / 2009 / Cilt: 24 - Sayı: 3

Kronik immün trombositopenik purpurası olan çocuklarda helikobakter pilori

Helicobacter pylori in children with chronic immune thrombocytopenic purpura

Pages
115–118
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Steroid or IVIG therapy resistant or frequent relapsing chronic ITP patients, investigation for Hp and eradication therapy for Hp positive patients may be recommended.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The role of Helicobacter pylori (Hp) infection in relation to the development and/or persistence of ITP in infected patients still remains controversial.
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Key Findings & Data:Material and Methods: For this purpose, 19 patients with chronic ITP were followed at department of Pediatric Hematology of Dicle University Hospital and were evaluated for Hp IgG antibody positivity and hematological parameters.
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Conclusion & Impact:Steroid or IVIG therapy resistant or frequent relapsing chronic ITP patients, investigation for Hp and eradication therapy for Hp positive patients may be recommended.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The role of Helicobacter pylori (Hp) infection in relation to the development and/or persistence of ITP in infected patients still remains controversial. The aim of this study was to determine the prevalence of Hp in chronic ITP and compare the incidence of Hp positivity with healthy control group. Material and Methods: For this purpose, 19 patients with chronic ITP were followed at department of Pediatric Hematology of Dicle University Hospital and were evaluated for Hp IgG antibody positivity and hematological parameters. Control group consisted of 24 healthy children followed up at the outpatient clinic. Results: Hp IgG was positive in 11 of 19 cases in the study group (57.8 %) and 12 of 24 cases in control group (53.4 %). In terms of Hp positivity, means there was no statistically significant difference between the two groups (p>0.005). Conclusion: Hp IgG seroprevalance in study and control groups were similar with other age matched studies reported from our country. In chronic ITP cases, the results were similar, and no significant difference was present between study and control groups. Steroid or IVIG therapy resistant or frequent relapsing chronic ITP patients, investigation for Hp and eradication therapy for Hp positive patients may be recommended.

Özet

Amaç: Son yıllarda Helicobacter Pylori (Hp)’nin ITP’li hastalarda daha yüksek oranda bulunduğu ve eradikasyon tedavisinini trombosit sayısını yükselttiğini gösteren bir çok çalışma literatürde mevcuttur. Bu çalışmada Kr ITP’li hastalarda Hp pozitifliğinin sağlıklı bireylere göre daha sık görülüp görülmediğinin araştırılması amaçlandı.Gereç ve Yöntem: Çalışmaya Dicle Üniversitesi çocuk sağlığı ve hastalıkları hematoloji polikliniğinde kronik ITP tanısısyla düzenli takiplere gelen izlenmekte olan 19 hasta ve kontrol grubu olarak çocuk polikliniğine başvuran sağlıklı 24 çocuk çalışmaya dahil edildi.Bulgular: Hasta grubunda 19 hastanın 11’inde (% 57.8), kontrol grubunda is 24 hastanın 12’sinde (% 50), toplamda çalışmaya alınan 43 hastanın 23 ünde (% 53.4) Hp IgG pozitif saptandı. Kr. İTP’li hastalarda Hp sıklığının artmadığı görüldü.Tartışma: İTP’ li hastalarda ve kontrol grubunda Helicobacter IgG seroprevelansı ülkemizde benzer yaş gruplarında yapılan çalışmalarla uyumlu idi. Kr. İTP hastalarında da benzer oranda bulundu ve kontrol grubuyla arasında anlamlı bir fark bulunamadı. Buradan yola çıkarak steroid ve immünglobulin tedavisine yanıt vermeyen veya tedavi sonrası trombositleri hızla düşen Kr. İTP olgularında Hp araştırılması ve sonucun müspet olduğu durumlarda eradikasyon tedavisinin verilmesini önerilmektedir.

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Cite This Article

OKUR, N., ÖZEL, A., SÖKER, M., OKUR, N. (2022). Kronik immün trombositopenik purpurası olan çocuklarda helikobakter pilori. Göztepe Tıp Dergisi, Cilt: 24 - Sayı: 3, 115–118. https://ajindex.com/articles/526191

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References (17)

  1. Imbach P. Immune thrombocytopenic purpura. In: Lilleyman J, Hann I, Blanchette V, eds. Pediatric Hematology, second ed. London: Churchill Livingstone Harcourt Publishers Ltd 1999;437-453
  2. Marshall BJ, Amstrong JA, McGechie DB, et al. Attempt to fulfil Koch’s postulates for pyloric Campylobacter. Med J Austr 1985;142:436-9
  3. Wotherspoon Doglioni C, Diss TC, Pan L, et al. Regression of primary low-grade B-cell gastric lymphoma of mucosa associated lymfoid tissue type after eradication of helicobacter Pylori. Lancet 1993;342(8871):575-7
  4. Cines DB, Blanchette VS, Douglas B. Immune thrombocytopenic purpura. N Engl J Med 2002;346:995-1008
  5. Provan D, Newland A. Fifty years of idiopatic trombocytopenic purpura (ITP): management of refractory ITP in adults. Br J Haematol 2002;118:933-44
  6. Rodeghiero F. Idiopatic trombocytopenic purpura: an old disease revisitedin the era of evidance-based medicine. Haematologica 2003;88:1081-7
  7. Franchini M, Veneri D. Helicobacter pylori infection and immune trombocytopenic purpura. Haematologica 2003;88:1087-91
  8. Huber MR, Kumar S, Tefferi A. Treatment advences in adult immune trombocytopenic purpura. Ann Hematol 2003;82;723-37
  9. Yilmaz E, DoğanY, Gurgoze MK. Seroprevalence of Helicobacter pylori infection among children and their parents in Turkey. J Pediatr Child Health 2002;38: 183-186
  10. Kelly SM, Piteher MCL, Farmery SM. Isolation of Helicobacter pylori from feces of patients with dyspepsia in the United Kingdom. Gastroenterology 1994;107:1671-1674
  11. McNulty CAM, Watson DM. Spiral bacteria of the gastric antrum. Lancet 1984;1068-69
  12. Price AB. The Sydney System: histological division. J Gastroenterol Hepatol 1991;6:209-222
  13. Soldinder E, Pilia MC, Piubello W. Multi-resistant idiopatic trombocytopenia successfully treated by eradication of helicobacter pylori. Dig Liv Dis 2001;33:732
  14. Jarque I, Andreu R, Llopis I. Absence of platelet response after eradication of helicobacter pylori in patients with chronic idiopatic trombocytopenic purpura. Br J Haematol 2001;115:1002-3
  15. Kumagai T, Sekigawa K, Hashimoto N. Remission of idiopathic thrombocytopcnic purpura by eradicating Helicobacter pylori after omeprazole monotherapy. Int J Hematol 2001;74:237-8
  16. Veneri D, Franchini M, Gottardi M. Efficacy of Helicobacter pylori cradication in enhancing platelet count in adult patients with idiopathic thrombocytopenic purpura. Haematologica 2002;87:1777-9
  17. Emilia G, Luppi M, MÖrselli M. Helic