Journals / Göztepe Tıp Dergisi / 2010 / Cilt: 25 - Sayı: 3

The clinical and electrophysiological characteristics of N-hexane neuropathy in shoe makers

Ayakkabı yapıcılarında N-hekzan nöropatisinin klinik ve elektrofizyolojik özellikleri

Pages
116–120
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusions: The results indicate that exposure to N-hexanes in shoe industry can cause symtomatic axonal neuropathy and the most common type of the neuropathy is mixed sensorymotor type.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Chronic inhalation of glues containing n-hexanes induces sensory-motor polyneuropathy.
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Key Findings & Data:In this study we aimed to describe the clinical and electrophysiological characteristics of the patients who had been followed up from our polyclinic between 2000-2005, as shoe makers working in the shoe industry.
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Conclusion & Impact:Conclusions: The results indicate that exposure to N-hexanes in shoe industry can cause symtomatic axonal neuropathy and the most common type of the neuropathy is mixed sensorymotor type.
🔬Design:Research Article
📍Scope:2000-2005 Verileri
⚙️Variables:Domain Parameters

Abstract

Objectives: Chronic inhalation of glues containing n-hexanes induces sensory-motor polyneuropathy. N-hexane neuropathy has also been described as case reports at the shoe industry workers be cause of its common use in the production of footwear. In this study we aimed to describe the clinical and electrophysiological characteristics of the patients who had been followed up from our polyclinic between 2000-2005, as shoe makers working in the shoe industry. Materials and methods: 26 shoe makers who have been admitted to our clinic with neuropathy symptoms have been included in the study. Neurological examination and electrophysiological studies as nerve conduction study were applied to all of the patients. Results: 21 of the 26 patients were male (80 %). The mean age of the patients was 34.5. The most common neurological symptoms were distally localized numbness (91.2 %) and distally localized muscle weakness (65.3 %). 10 patients (39 %) showed normal electrophysiological findings while 16 (61 %) had electrophysiologically neuropathic findings. The main changes in the nerve conduction study were reduced amplitude of the sensory action potentials, followed by reduced amplitude of motor action potentials, reduction in motor conduction velocities and increase in distal latencies. 7 patients (43 %) had mixed sensory-motor axonal polyneuropathy while 3 (18 %) of them had motor and 6 (37 %) of them had sensory axonal neuropathy. Conclusions: The results indicate that exposure to N-hexanes in shoe industry can cause symtomatic axonal neuropathy and the most common type of the neuropathy is mixed sensorymotor type.

Özet

Amaç: N-hekzan içeren yapıştırıcıların kronik inhalasyonu, duysal-motor aksonal polinöropatiye neden olmaktadır. N-hekzan nöropatisi yine, ayakkabı üretiminde sıklıkla kullanılmasından dolayı, ayakkabı işçilerinde de vaka sunumları şeklinde bildirilmiştir. Bu çalışmada, polikliniğimizden 2000-2005 yılları arasında takibi yapılan ayakkabı işçilerinin klinik ve elektrofizyolojik özelliklerinin tanımlanması amaçlanmıştır. Gereç ve Yöntem: Polikliniğimize nöropati semptomları ile başvuran 26 ayakkabı işçisi çalışmaya alındı. Bütün hastalara nörolojik muayene ve sinir ileti çalışmalarını içeren elektrofizyolojik çalışma yapıldı. Bulgular: 26 hastanın 2’si erkekti (% 80). Hastaların ortalama yaşı 34.5 idi. En sık nörolojik semptomlar, distal lokalizasyonlu uyuşukluk (% 91.2) ve distal lokalizasyonlu kas güçsüzlüğü (% 65.3) idi. 10 hastada (% 39) normal elektrofizyolojik bulgular saptanırken, 16 (% 61) hastada elektrofizyolojik olarak nöropati bulguları saptandı. Sinir ileti çalışmalarında en belirgin değişiklikler, duysal aksiyon potansiyel amplitüdlerinde küçülme, motor aksiyon potansiyel amplitüdlerinde küçülme, motor ileti hızlarında yavaşlama ve distal latanslarda uzama idi. 7 hastada (+43) mikst duysal-motor aksonal polinöropati, 3 hastada (% 18) motor ve 6 hastada (% 37) duysal aksonal nöropati varlığı mevcuttu. Tartışma: Ayakkabı endüstrisinde N-hekzan maruziyeti, semptomatik aksonal nöropatiye neden olmakta ve en sık rastlanana nöropati tipi ise mikst duysal-motor tip olarak karşımıza çıkmaktadır.

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Cite This Article

ÖZKAN, A., CANDAN, F., CANTÜRK, A. İ., AKYÜZ, E., IŞIK, N. (2022). The clinical and electrophysiological characteristics of N-hexane neuropathy in shoe makers. Göztepe Tıp Dergisi, Cilt: 25 - Sayı: 3, 116–120. https://ajindex.com/articles/526186

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References (12)

  1. Smith AG, Albers JW. N-hexane neuropathy due to rubber cement sniffing. Muscle and Nevre 1997; 20:1445-50
  2. Chang Ap, England JD, Garcia CA. Focal conduction block in n-hexane polyneuropathy. Muscle and Nevre 1998; 21:964-69
  3. Chang CM, Yu CW, Fong KY. N-hexane neuropathy in offset printers. J Neurol Neurosurg Psychiatry 1993; 56:538- 42
  4. Sadeghniat K, Pooryaghoob G, Rafeemanesh E. N-hexane neuropathy due to shoemaking: Report of five cases. Acta Medica Iranica 2005; 43(1):71-74
  5. Kuwabara S, Kai MR, Nagase H. N-hexane neuropathy caused by addictive inhalation: Clinical and electrophysiological features. Eur Neurol 1999; 41(3):163-7
  6. Pastore C, Marhuenda D, Martı J. Early diagnosis of n-hexane caused neuropathy. Muscle and Nevre 1994; 17:981-86
  7. Passero S, Battistini N, Cioni R. Toxic polyneuropathy of shoe workers in Italy; a clinical, neurophysiological and follow-up study. Ital J Neurol Sci 1983; 4(4):463-72
  8. Iida M. Neurophysiological studies of n-hexane polyneuropathy in the sandal factory. Electroencephalogr Clin Neurophysiol Suppl 1982; 36:671-81
  9. Ruff RL, Petito CK, Acheson LS. Neuropathy associated with chronic low level exposure to n-hexane. Clin Toxicol 1981; 18:515-19
  10. Ehyai A, Freemon FR. Progressive optic neuropathy and sensorineural hearing loss due to chronic glue sniffing. J Neurol Neurosurg Psychiatry 1983; 46:349-51
  11. Puri V, Chaudhry N, Tatke M. N-hexane neuropathy in screen printers. Electromyogr Clin Neurophysiol 2007; 47(3):145-52
  12. Pastore C, Izura V, Marhuenda D. Partial conduction blocks in n-hexane neuropathy. Muscle and Nerve 2002; 26(1):132-5.