AI Summary & Key Takeaways
AI InsightThrombocytopenia were found in newborns, along with the main reason to do thrombocytopenia, it should bring about alloimmune thrombocytopenia in the differential diagnosis.
📌 3 Key Takeaways
Abstract
Neonatal alloimmune thrombocytopenia is charecterised by aganist fetal platelet antigens result of maternal alloimmunization. Maternal platelet count is often normal. Intracranial hemorrhage may develop alloimmune thrombocytopenia. Morever randomly platelets can be used treatment presence of serious or life-threatening bleeding or thrombocytopenia, in patients have antigen negative platelets. It can result permanent neurological damage in fetus or newborn death. Nowadays, intravenous immunoglobulin treatment is the essential treatment of alloimmune thrombocytopenia. The our case delivery was caesarian section due to brech presentation. Because of the investigation due to postnatal hyperbilirubinemia at the laboratory evaluation performed in 69. hours and platelet count was revealed 19.000/mm3, peripheral blood smear revealed single large platelets. The mother's platelet count was normal. Platelet antibodies has resulted negative. Cranial and abdominal ultrasonography was not detected bleeding or hematoma in cranium and abdomen. IVIG were given a single dose 1 gfkg/day at treatment. 10 days after discharge, this case platelets count was 280001mm3. The platelets due to again to fall into the case second IVIG therapy I g/kg was given. Thrombositopenia was not repeated in follow-up. Thrombocytopenia were found in newborns, along with the main reason to do thrombocytopenia, it should bring about alloimmune thrombocytopenia in the differential diagnosis.
Özet
Yenidoğan alloimmun trombositopenisi, fetal trombosit antijenlerine karşı maternal alloimmünizasyon ile karakterizedir. Annenin trombosit sayısı sıklıkla normaldir. Fetusta veya yeni-doğanda ölümle veya nörolojik hasarla sonııçlanabilen intrak-raniyal kanama gelişebilir. Tedavide ciddi trombositopeni veya hayatı tehdit edeıı kanama varlığında antijen negatif trombosit süspansiyonu veya random trombosit süspansiyonu kullanıla-bilir.Yüksek doz intravenöz immunglobulin tedavisi günümüzde başlıca tedavi seçeneğidir. Makat geliş nedeniyle sezaryan ile zamanında doğan olgunun, postnatal 69. saatinde sarılığı nedeniyle yapılan tetkiklerinde, trombosit sayısı 19.000/mm3 bulundu. Periferik yaymada tekli iri trombositler tespit edildi. Annenin trombosit sayısı normaldi. Trombosit antikorları negatif sonuçlandı. Kraniyal ve batın USG'lerinde kanama veya hematom saptanmadı. Tedavi olarak 1 gr/kg/gün İVİG verildi. Taburculuktan on gün sonra trombositlerinin tekrar 280001mm3'e düşmesi üzerine 2. doz 1 gr/kg İVİG tedavisi verildi. İzleminde trombositopenisi tekrarlamadı. Yenidoğanda tespit edilen trombositopeni, öncelikli nedenler ile birlikte alloimmun trombositopeniyi de akla getirmelidir.