Journals / Göztepe Tıp Dergisi / 2012 / Cilt: 27 - Sayı: 2

Levels of trace elements and oxidative parameters in Malignant Mesothelioma

Malign Mezotelyomada eser element ve oksidatif parametrelerin düzeyi

Pages
58–61
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In addition, malonyl dialdehyde(MDA) levels were higher in theMPM group, and nitricoxide (NO) was lower in the MPM group (Table 1).The role trace element and oxidative parameters in the followup, progression and prognosis of MPM should be investigatedin larger scale studies.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Malignant pleural mesothelioma (MPM) is a type of a cancerwith a poor prognosis and patients can benefit form the treatmentof only partially.
📊
Key Findings & Data:In this study levelsof trace elements and oxidative parameters. were analyzed inMPM patientsForty-eight MPM patients and 52 control cases without anychronic diseases who were followed up in our UniversityHospital followed were included in the study.
💡
Conclusion & Impact:In addition, malonyl dialdehyde(MDA) levels were higher in theMPM group, and nitricoxide (NO) was lower in the MPM group (Table 1).The role trace element and oxidative parameters in the followup, progression and prognosis of MPM should be investigatedin larger scale studies.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Malignant pleural mesothelioma (MPM) is a type of a cancerwith a poor prognosis and patients can benefit form the treatmentof only partially. Trace elements play a direct or indirectrole. in the pathogenesis of many diseases. In this study levelsof trace elements and oxidative parameters. were analyzed inMPM patientsForty-eight MPM patients and 52 control cases without anychronic diseases who were followed up in our UniversityHospital followed were included in the study. The study included24 male and 24 female patients. The mean age of patientswith MPM were 55.8 years. Total of 39 patients had asbestosexposure (81.3 %) and mean duration of exposure to asbestoswas 34 years. Total epithelial types in 33 patients (68.8 %)were detected. Pleural fluid cytology was positive in 13 patients(27.1 %).Levels of copper (Cu) levels were higher than the controlgroup in patients with MPM. Zinc (Zn) levels did not differbetween the two groups (Table 1). In addition, malonyl dialdehyde(MDA) levels were higher in theMPM group, and nitricoxide (NO) was lower in the MPM group (Table 1).The role trace element and oxidative parameters in the followup, progression and prognosis of MPM should be investigatedin larger scale studies.

Özet

Malign Plevral Mezotelyoma (MPM) kötü prognoza sahip birkanser türüdür ve hastaların yalnızca az bir kısmı tedavidenyarar görür. Eser elementler birçok hastalığın patogenezindedoğrudan veya dolaylı olarak rol oymaktadır. Bu çalışmadaMPM hastalarında eser element ve oksidatif parametrelerindüzeyinin araştırılması amaçlanmıştır.Üniversite hastanesinde takip edilen 48 MPM hastası ve herhangibir kronik hastalığı olmayan 52 kontrol olgusu çalışmayaalınmıştır. Çalışmaya 24 erkek ve 24 kadın hasta dahil edilmiştir.MPM hastalarının yaş ortalaması 55,8 yıldı. Toplam 39hastanın asbest teması vardı (% 81,3) ve ortalama asbesttemas süresi 34 yıldı. Toplam 33 hastada epitelyal tip (% 68,8)saptandı. Plevral sıvı sitolojisi ise 13 hastada pozitifti (% 27,1).Eser element seviyelerine bakıldığında Bakır (Cu) düzeyiMPM hastalarında kontrol grubuna göre yüksek saptandı.Çinko (Zn) düzeyleri arasında ise her iki grup arasında farkyoktu (Tablo 1). Ayrıca Malonil dialdehit (MDA) düzeyleriMPM grubunda yüksek ve Nitrik oksit (NO) ise MPM grubundadüşük olarak saptandı (Tablo 1).MPM hastalığında hastalığın takibinde ve prognozda eser elementve oksidatif parametrelerin rolleri konusunda geniş seriliçalışmalara gereksinim vardır.

🔖

Cite This Article

KAPLAN, M. A., KÜÇÜKÖNER, M., TANRIKULU, A. Ç., PALANCİ, Y., EVLİYAOĞLU, O., ŞEN, H., ŞENYİĞİT, A., SEZGİ, C., ABAKAY, A. (2022). Levels of trace elements and oxidative parameters in Malignant Mesothelioma. Göztepe Tıp Dergisi, Cilt: 27 - Sayı: 2, 58–61. https://ajindex.com/articles/526090

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (3)

  1. Emri S, Akbulut H, Zorlu F, Dinçol D, Akay H, Güngen Y, Içli F. Prognostic significance of flow cytometric DNA analysis in patients with malignant pleural mesothelioma. Lung Cancer 2001;33:109-114.
  2. Bariş B, Demir AU, Shehu V, Karakoca Y, Kisacik G, Bariş YI. Environmental fibrous zeolite (erionite) exposure and malignant tumors other than mesothelioma. J Environ Pathol Toxicol Oncol 1996;15:183-189. PMid:9216804 3. Dumortier P, Coplü L, de Maertelaer V, Emri S, Baris I, De Vuyst P. Assessment of environmental asbestos exposure in Turkey by bronchoalveolar lavage. Am J Respir Crit Care Med 1998;158:1815-1824. PMid:9847273 4. Carkanat AI, Abdurrahman A, Abakay O, Cengizhan S, Selimoglu SH, Senyigit A. The incidence of mesothelioma has not decreased for the last twenty years in Southeast region of Anatolia. Afr Health Sci 2011;11(3):346-352. PMid:22275923 PMCid:3260992 5. Senyiğit A, Babayiğit C, Gökirmak M, Topçu F, Asan E, Coşkunsel M, Işik R, Ertem M. Incidence of malignant pleural mesothelioma due to environmental asbestos fiber exposure in the southeast of Turkey. Respiration 2000;67(6):610-614.
  3. Sattar N, Scott HR, McMillan DC, Talwar D, O'Reilly DS, Fell GS. Acute-phase reactants and plasma trace element concentrations in non-small cell lung cancer patients and controls. Nutr Cancer 1997;28:308-312. http://dx.doi.org/10.1080/01635589709514592 PMid:9343841 7. Ferrigno D, Buccheri G, Camilla T. Serum copper and zinc content in nonsmall cell lung cancer: abnormalities and clinical correlates. Monaldi Arch Chest Dis 1999;54:204-208. PMid:10441970 8. Kaynar H, Meral M, Turhan H, Keles M, Celik G, Akcay F. Glutathione peroxidase, glutathione-Stransferase, catalase, xanthine oxidase, Cu-Zn superoxide dismutase activities, total glutathione, nitric oxide, and malondialdehyde levels in erythrocytes of patients with small cell and non-small cell lung cancer. Cancer Lett 2005;227(2):133-139. http://dx.doi.org/10.1016/j.canlet.2004.12.005 PMid:16112416 9. Hasegawa S, Koshikawa M, Takahashi I, Hachiya M, Furukawa T, Akashi M, Yoshida S, Saga T. Alterations in manganese, copper, and zinc contents, and intracellular status of the metal-containing superoxide dismutase in human mesothelioma cells. J Trace Elem Med Biol 2008;22(3):248-255. http://dx.doi.org/10.1016/j.jtemb.2008.05.001 PMid:18755401 10. Esterbauer H, Cheeseman KH. Determination of aldehydic lipid peroxidation prod