Journals / Göztepe Tıp Dergisi / 2013 / Cilt: 28 - Sayı: 3

Antihypertensive therapy-induced pancreatitis

Antihipertansif ilaç kullanımına bağlı akut pankreatit

Pages
136–140
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Patients receiving antihypertensives should closely followed up in terms of drug related AP.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Akut pancreatitis (AP) is a sudden-onset inflamma- tion of pancreatic tissue characterized by abdominal pain and increased pancreatic enzymes in serum.
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Key Findings & Data:Material and methods: Sixty seven patients (39 males, and 28 females) were enrolled into the study.
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Conclusion & Impact:Patients receiving antihypertensives should closely followed up in terms of drug related AP.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Akut pancreatitis (AP) is a sudden-onset inflamma- tion of pancreatic tissue characterized by abdominal pain and increased pancreatic enzymes in serum. Cholelithiasis and alcohol intake are the most common etiologic factors of AP. Drug use is a rare cause of AP. Our aim is to determine the frequency of antihypertensive medication induced AP. Material and methods: Sixty seven patients (39 males, and 28 females) were enrolled into the study. The mean age was 52.88±19.06 years. Demographic and laboratory data of the patients were recorded. Clinical and radiological staging were performed according to criteria proposed by Ranson and Balthazar. Results: The frequency of antihypertensive therapy-induced AP was 10.4 %. There was no significant difference between antihypertensive therapy-induced AP and AP due to other etio- logic factors in terms of Ranson criteria, duration of hospitali- zation and Balthazar scores (p>0.05). Conclusion: We observed higher frequency of antihypertensive therapy-induced AP when compared to previous reports. This might be attributed to the fact that cholelithiasis-induced AP cases were followed up in the Department of General Surgery and higher frequency of comorbid chronic diseases in our patients. Patients receiving antihypertensives should closely followed up in terms of drug related AP.

Özet

Amaç: Akut pankreatit (AP), karın ağrısı ve serumda pankreasenzimlerinin artışı ile karakterize ani başlayan bir pankreasinflamasyonudur. AP’in en sık nedeni safra kesesi taşları ve alkol kullanımıdır. İlaçlar AP’in yaygın olmayan ve önemli nedenleri arasındadır. Bu çalışmada AP tanısı ile yatan hasta- larımızda antihipertansif ilaç kullanım sıklığını tespit etmeyi amaçladık.Gereç ve Yöntem: Çalışmaya iç hastalıkları kliniğinde AP teş- hisi ile yatırılan 39 erkek, 28 kadın, ortalama yaş (52.88±19.06) 67 hasta alındı. Hastaların demografik ve labo- ratuvar değerleri kaydedildi. AP şiddeti klinik olarak Ranson kriterlerine ve radyolojik olarak Balthazar kriterlerine göre değerlendirildi. Bulgular: AP’li olguların % 10.4’ü antihipertansif ilaç kulla- nımına sekonder olarak değerlendirildi. Antihipertansif ilaç kullanımına bağlı AP gelişen hastaların Ranson kriterleri, yatış gün süreleri ve Balthazar skorları diğer nedenlere bağlı AP’ler arasında istatistiksel olarak anlamlı fark bulunamadı (p>0.05). Tartışma: Çalışmamızda AP’li hastalarda antihipertansif ilaçkullanım sıklığının literatürde belirtilen oranlardan daha fazlaolduğu görüldü. Bunun nedeni safra kesesi taşına bağlı APolgularının genel cerrahi servislerinde takip edilmeleri ve has- talarımızda kronik hastalık sıklığının fazla olmasına bağlı ola-bilir. Antihipertansif ilaç kullanan hastalar AP açısındanyakından izlenmelidir.

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Cite This Article

ŞİT, D., YORULMAZ, E., GÖKMEN, E., GÜLLÜ, B. E., ATAY, A. E. (2022). Antihypertensive therapy-induced pancreatitis. Göztepe Tıp Dergisi, Cilt: 28 - Sayı: 3, 136–140. https://ajindex.com/articles/526047

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