Journals / Göztepe Tıp Dergisi / 2014 / Cilt: 29 - Sayı: 2

Correlation of histopathological and MRI findings in non-alcoholic fatty liver

Nonalkolik karaciğer yağlanmasında histopatolojik bulguların MR ile korelasyonu

Pages
82–87
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: MRI study was found as a sensitive method to determine the steatosis and degree of steatosis.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: The aim of this study is to determine the correlation between hepatic steatosis with quantitative MR findings in patients diagnosed by chemical shift magnetic resonance imaging method, and previous liver biopsy as nonalcoholic fatty liver disease.
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Key Findings & Data:Materials and Methods: Thirty-one patients (15 females, 16 males) who had histopathologically diagnosed as nonalcoholic liver disease in Goztepe Training and Research Hospital Department of Radiology between 01.01.2011-15.02.2011underwent dual-echo GRE chemical shift imaging method.
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Conclusion & Impact:Conclusion: MRI study was found as a sensitive method to determine the steatosis and degree of steatosis.
🔬Design:Research Article
📍Scope:2011 Verileri
⚙️Variables:Domain Parameters

Abstract

Purpose: The aim of this study is to determine the correlation between hepatic steatosis with quantitative MR findings in patients diagnosed by chemical shift magnetic resonance imaging method, and previous liver biopsy as nonalcoholic fatty liver disease. Materials and Methods: Thirty-one patients (15 females, 16 males) who had histopathologically diagnosed as nonalcoholic liver disease in Goztepe Training and Research Hospital Department of Radiology between 01.01.2011-15.02.2011underwent dual-echo GRE chemical shift imaging method. Using SI signal intensity ratio (same phase)-SI (external phase) / 2 SI (same phase) ratio, intensity formula was constructed. Rates between 9 to 18 % were accepted as internediate steatosis, and higher rates than 18 % indicated severe steatosis. Results: In MRI evaluation of steatotic conditions, the patients had grade 1 (n=7; 22.6 %), 2 (n=19; 61.3 %), and 3 (n=5; 16.1 %) steatosis. Based on histopathological evaluation, 19,4 % of patients (n=6), grade 1, 64,5 % 'patients (n=20) grade 2 and 16,1 % of patients (n=5) had grade 3 steatosis. The degree of steatosis demonstrated the presence of a strong correlation between histopathological and MRI evaluations. Six (19.4 %) patients in both groups had grade 1 steatosis. Histopathologically, 20 (64.5 %) patients had grade 2 steatosis, while grade 2 steatosis was detected in 19 patients using MR criteria.. One patient had grade 1 steatosis. Finally, in both groups, 16.1 % (n=5) of the patients had grade 3 steatosis. The degree of steatosis grading with histopathology and MRI correlated with a high level of compliance (94 %) as assessed by Cohen Kappa method. Conclusion: MRI study was found as a sensitive method to determine the steatosis and degree of steatosis.

Özet

Amaç: Bu çalışmanın amacı kimyasal şift yöntemi ile daha önce karaciğer biyopsisi ile tanı konmuş nonalkolik yağlı karaciğer hastalığı olan hastalarda hepatik steatozun kantitatif MR ile korelasyonunu belirlemektir. Gereç ve Yöntem: 01.01.2011-15.02.2011 tarihleri arasında, Göztepe Eğitim ve Araştırma Hastanesi Radyoloji Kliniğinde, histopatolojik nonalkolik karaciğer hastalığı tanısı almış olan 31 hastada (15 kadın, 16 erkek) dual-eko GRE kimyasal şift görüntüleme yöntemi yapıldı. Kullanılan sinyal intensite oranı SI (aynı faz)-SI (dış faz)/2SI (aynı faz) formülle intensite ölçümü belirlendi. Ölçüme göre %9-18 arası oranlar orta yağlanmayı, % 18 ve üzeri oranlar aşırı yağlanmayı göstermektedir. Bu oranlar histopatolojik bulgularla korelasyon gösterdi. Bulgular: Olguların MR ile yapılan steatoz değerlendirmesinde % 22.6'sında (n=7) grade 1, % 61.3'ünde (n=19) grade 2 ve % 16.1'inde (n=5) grade 3 steatoz saptandı. Olgularımızın histopatolojik olarak yapılan steatoz değerlendirmesinde % 19.4'ünde (n=6) grade 1, % 64,5'inde (n=20) grade 2 ve % 16.1'inde (n=5) grade 3 steatoz saptandı. Histopatolojik steatoz dercesi ile MR'da saptanan steatoz derecelerinin oldukça korele olduğu saptandı. Bu iki yöntemin karşılaştırılmasında, her iki grupta da hastaların % 19.4'ünde (n=6) grade 1 steatoz saptandı. Histopatolojik olarak grade 2 steatoz saptanan 20 hastanın (% 64,5) 19'unda MR ile de grade 2 steatoz saptanırken, 1 olguda grade 1 steatoz saptandı. Son olarak her iki yöntemde de olguların % 16.1'inde (n=5) grade 3 steatoz saptandı. Mevcut sonuçlarla histopatolojik steatoz derecesi ile MR'da saptanan steatoz dereceleri arasında Cohen Kappa uyum düzeyi % 94 olarak saptanmış olup, yüksek düzeyde bir uyum görülmektedir.Sonuç: Çalışmamızda hepatosteatozu ve steatoz derecesini saptamada MR'ın oldukça duyarlı bir yöntem olduğu görülmektedir.

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Cite This Article

TÜTEN, M. F., KUTLU, Y., ÖZDAMARLAR, U., YILMABAŞAR, M. G., HAYIRLIOĞLU, D. A., KURU, L. İ. (2022). Correlation of histopathological and MRI findings in non-alcoholic fatty liver. Göztepe Tıp Dergisi, Cilt: 29 - Sayı: 2, 82–87. https://ajindex.com/articles/526017

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