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Journals / GORM:Gynecology Obstetrics & Reproductive Medicine / 2021 / Cilt: 27 - Sayı: 2

Placental Maspin Gene Expression Pattern May Be Used to Distinguish Between Preeclampsia and Intrauterine Growth Restriction

Feride İffet ŞAHİN
Yusuf Aytaç TOHMA
Erkan YURTCU
Esra KUŞÇU
Göğşen ÖNALAN
Hulusi Bülent ZEYNELOĞLU
Yunus Kasım TERZİ
Pages
99–104
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These findings support that molecular pathology between preeclampsia and IUGR might be different at the molecular level and maspin levels in the placenta may be used to differentiate preeclampsia from IUGR.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: Maspin is one of the members of serin protease inhibitor superfamily, and acts as a tumor suppressor protein.
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Key Findings & Data:For this purpose, placental tissue samples were obtained from pregnancies 13 with intrauterine growth retardation, and 6 with preeclampsia, and also 12 tissues from women without preeclampsia or intrauterine growth retardation history were included as controls.
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Conclusion & Impact:These findings support that molecular pathology between preeclampsia and IUGR might be different at the molecular level and maspin levels in the placenta may be used to differentiate preeclampsia from IUGR.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: Maspin is one of the members of serin protease inhibitor superfamily, and acts as a tumor suppressor protein. Here we report maspin expression in placental tissues of preeclampsia or intrauterine growth retardation pregnancies. STUDY DESIGN: Maspin expression level was analyzed by semi-quantitative RT-PCR method. For this purpose, placental tissue samples were obtained from pregnancies 13 with intrauterine growth retardation, and 6 with preeclampsia, and also 12 tissues from women without preeclampsia or intrauterine growth retardation history were included as controls. RESULTS: Maspin expression was found to be 11-fold higher in placentas from preeclampsia patients than placentas from intrauterine growth retardation patients (p=0.036). However, there was no difference between preeclampsia and control groups (p=0.76), and intrauterine growth retardation and control groups (p=0.849). CONCLUSION: As far as we know this is the first study reporting expression level of maspin in placental tissues of pregnancies with intrauterine growth retardation. These findings support that molecular pathology between preeclampsia and IUGR might be different at the molecular level and maspin levels in the placenta may be used to differentiate preeclampsia from IUGR.

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Cite This Article

ŞAHİN, F. İ., TOHMA, Y. A., YURTCU, E., KUŞÇU, E., ÖNALAN, G., ZEYNELOĞLU, H. B., TERZİ, Y. K. (2022). Placental Maspin Gene Expression Pattern May Be Used to Distinguish Between Preeclampsia and Intrauterine Growth Restriction. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 27 - Sayı: 2, 99–104. https://ajindex.com/articles/525833

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References (12)

  1. Brar HS, Rutherford SE. Classification of intrauterine growth retardation. Semin Perinatol. 1988;12(1):2-10. PMID: 3287628
  2. Pollack RN, Divon MY. Intrauterine growth retardation: definition, classification, and etiology. Clin Obstet Gynecol. 1992;35(1):99-107. doi:10.1097/00003081-199 203000-00015
  3. Gray PH, O'Callaghan MJ, Harvey JM, Burke CJ, Payton DJ. Placental pathology and neurodevelopment of the in-fant with intrauterine growth restriction. Dev Med Child Neurol. 1999;41(1):16-20. doi: 10.1017/s0012162299000 043
  4. Lain KY, Roberts JM. Contemporary concepts of the pathogenesis and management of preeclampsia. JAMA. 2002;287(24):3183-6. doi: 10.1001/jama.287.24.3183
  5. Bahr BL, Price MD, Merrill D, Mejia C, Call L, Bearss D, et al. Different expression of placental pyruvate kinase in normal, preeclamptic and intrauterine growth restriction pregnancies. Placenta. 2014;35(11):883-90. doi: 10.1016/ j.placenta.2014.09.005
  6. Ilekis JV, Tsilou E, Fisher S, Abrahams VM, Soares MJ, Cross JC, et al. Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Develop - ment. Am J Obstet Gynecol. 2016;215(1 Suppl): S1-S46. doi: 10.1016/j.ajog.2016.03.001
  7. Telang MA, Bhutkar SP, Hirwani RR. Analysis of patents on preeclampsia detection and diagnosis: a perspective. Placenta. 2013;34(1):2-8. doi: 10.1016/j.placenta.2012. 10.017
  8. Redman CW, Sargent IL. Latest advances in understanding preeclampsia. Science. 2005;308(5728):1592-4. doi: 10.1126/science.1111726
  9. Geusens N, Verlohren S, Luyten C, Taube M, Hering L, Vercruysse L, et al. Endovascular trophoblast invasion, spiral artery remodelling and uteroplacental haemodynamics in a transgenic rat model of pre-eclampsia. Placenta. 2008;29(7):614-23. doi:10.1016/j.placenta. 2008.04.005
  10. Liu Q, Qiao FY, Shi XW, Liu HY, Gong X, Wu YY. Promoter hypomethylation and increased maspin expression in preeclamptic placentas in a Chinese population. Placenta. 2014;35(11):876-82. doi:10.1016/j.placenta. 20 14.08.088
  11. Zhang Y, Liu H, Shi X, Qiao F, Zeng W, Feng L, et al. Maspin impairs the function of endothelial cells: an implying pathway of preeclampsia. BMC Pregnancy Childbirth. 2017;17(1):328. doi: 10.1186/s12884-017-15 25-z
  12. Li HW, Leung SW, Cheung AN, Yu MM, Chan LK, Wong YF. Expression of maspin in gestational trophoblastic disease. Gynecol Oncol. 2006;101(1):76-81. doi: 10