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Journals / Gazi Medical Journal / 2017 / Cilt: 28 - Sayı: 4

Protective Effects of Resveratrol in a Rat Model of Ischemia-Reperfusion Injury of Sciatic Nerve

Rat Siyatik Siniri Iskemi-Reperfüzyon Hasarında Resveratrolün Koruyucu Etkileri

Özge Tuğçe PAŞAOĞLU
Ayşe GÜNDOĞDU ÇAKIR
Gülnur KAPLANOĞLU TAKE
Onur AKARCA
Özgür ÖCAL
Erkut Baha BULDUK
Aydın PAŞAOĞLU
Pages
260–265
Publication Date
2022-10-19
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: This study revealed the antioxidant effect of resveratrol as an inhibitor of lipid peroxidation.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of this study was to determine the effects of resveratrol on ischemia- reperfusion (I/R) injury in the rats sciatic nerve.
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Key Findings & Data:Methods: We used 18 Wistar rats anesthetized with ketamine (50 mg/kg-im).
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Conclusion & Impact:Conclusion: This study revealed the antioxidant effect of resveratrol as an inhibitor of lipid peroxidation.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study was to determine the effects of resveratrol on ischemia- reperfusion (I/R) injury in the rats sciatic nerve. Methods: We used 18 Wistar rats anesthetized with ketamine (50 mg/kg-im). In the sham group, we only performed the surgery and not administer any medication. In the ischemia group, we generated I/R injury in 5 minute intervals with medical treatment of saline only. In the resveratrol group, we brought about the same I/R injury but gave resveratrol before the surgery by per oral. After sacrifice, we studied blood and nerve tissue samples. We evaluated the damage with malondialdehyde (MDA), nitric oxide (NO), and total antioxidant capacity (TAC), both in tissue and blood. Results: Evaluation of serum levels of antioxidant markers and tissue samples demonstrated statistically significant effects of resveratrol in ischemiareperfusion injury. Conclusion: This study revealed the antioxidant effect of resveratrol as an inhibitor of lipid peroxidation.

Özet

Amaç: Bu çalışmanın amacı sıçan siyatik sinirinde resveratrolün iskemireperfüzyon (I / R) hasarı üzerine etkilerini belirlemektir. Yöntem: Ketamin (50 mg / kg-im) ile anestezi uygulanmış 18 adet Wistar sıçanı kullandık. Sham grubunda herhangi bir ilaç vermeden sadece cerrahi uyguladık. İskemi grubunda 5 dakika aralıklarla I / R hasarı oluşturduk ve medikal tedavi olarak sadece salin verdik. Resveratrol grubunda da aynı I / R hasarını oluşturduk, ancak oral yolla işlemden önce resveratrol verdik. Ratlar sakrifiye edildikten sonra kan ve sinir doku örnekleri aldık. Hem doku hem de kandaki malondialdehit (MDA), nitrik oksit (NO) ve toplam antioksidan kapasiteleri (TAC) ile hasarı değerlendirdik. Bulgular: Antioksidan belirteçlerin ve doku örneklerinin serum düzeylerinin değerlendirilmesi, iskemi-reperfüzyon hasarında resveratrolün istatistiksel olarak anlamlı etkilerini ortaya koymuştur. Sonuç: Bu çalışma lipid peroksidasyonunun bir önleyicisi olarak resveratrolün antioksidan etkisini ortaya koymuştur.

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Cite This Article

PAŞAOĞLU, Ö. T., ÇAKIR, A. G., TAKE, G. K., AKARCA, O., ÖCAL, Ö., BULDUK, E. B., PAŞAOĞLU, A. (2022). Protective Effects of Resveratrol in a Rat Model of Ischemia-Reperfusion Injury of Sciatic Nerve. Gazi Medical Journal, Cilt: 28 - Sayı: 4, 260–265. https://ajindex.com/articles/519892

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