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Journals / Gazi Medical Journal / 2017 / Cilt: 28 - Sayı: 1

Are Peripheral Blood Derived Inflammation Markers Prognostic Indicators in Breast Cancer?

Periferik Kanda Ölçülen İnflamasyon Belirteçlerinin Meme Kanserli Hastalarda Prognostik Önemi var mı?

Osman DOĞRU
Hande KOKSAL
Meryem İlkay EREN KARANİS
Emet Ebru NAZİK
Ersin TURAN
Umut ULUSOY
Pages
39–41
Publication Date
2022-10-19
DOI
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Also both NLR and PLR were significantwhen N0 patients compared with N1 patients (p

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Objective & Hypothesis:Objective: Peripheral blood derived inflammation based scores are proposedas prognostic markers in solid tumors especially in gastrointestinal system.We aimed to investigate the association between neutrophyl/lymphocyteratio (NLR, platelet/lymphocyte ratio (PLR) and breast cancer in means ofprognostic forecast.Methods: Of 190 patients diagnosed and operated for breast cancer. 160patients with available pretreatment blood count were included.
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Key Findings & Data:Ultrasound,mammography, and pathology results were also recorded.Results: The median age was 50 years at the time of diagnosis (28-90 years).Family history was positive in 11 patients.
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Conclusion & Impact:Also both NLR and PLR were significantwhen N0 patients compared with N1 patients (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Peripheral blood derived inflammation based scores are proposedas prognostic markers in solid tumors especially in gastrointestinal system.We aimed to investigate the association between neutrophyl/lymphocyteratio (NLR, platelet/lymphocyte ratio (PLR) and breast cancer in means ofprognostic forecast.Methods: Of 190 patients diagnosed and operated for breast cancer. 160patients with available pretreatment blood count were included. Ultrasound,mammography, and pathology results were also recorded.Results: The median age was 50 years at the time of diagnosis (28-90 years).Family history was positive in 11 patients. There were 139 patients withinvasive ductal carcinoma, 15 patients with invasive lobuler carcinoma. Therewas no association with histopathological type of the tumor and peripheralblood derived inflammation markers. The difference in PLR between T1 andT4 tumors was statistically significant. Also both NLR and PLR were significantwhen N0 patients compared with N1 patients (p

Özet

Amaç: Periferik kanda saptanan inflamasyon belirteçleri gastrointestinal sistem tümörleri öncelikli olmak üzere birçok solid tümörde prognostik belirteç olarak kullanılmaktadır. Biz de bu çalışmada nötrofil/lenfosit oranı ve trombosit/ lenfosit oranları ile meme kanseri arasında prognoz belirleme bakımından ilişki olup olmadığını araştırdık. Yöntem: Meme kanseri nedeniyle ameliyat edilen 190 hastadan preoperatif kan tetkikleri sonucuna ulaşılan 160 hasta çalışmaya dâhil edildi. Ultrasonografi, mamografi ve patoloji sonuçları da kaydedildi. Bulgular: Hastaların yaşı 28 ile 90 arasında değişmekte olup tanı anındaki median yaş 50 idi. Aile öyküsü 11 hastada vardı. 139 hasta invaziv duktal karsinom tanısı alırken, 15 hasta invaziv lobuler karsinom tanısı almıştı. Kanserin histopatolojik tipi ile inflamasyon belirteçleri arasında istatistiksel olarak anlamlı ilişki saptanmadı. Tümör boyutları açısından bakıldığında T1 ve T4 tümörler arasında trombosit/lenfosit oranı açısından anlamlı fark saptandı. N0 ile N1 hastalar karşılaştırıldığında ise hem nötrofil/lenfosit oranı hem de trombosit /lenfosit oranı açısından fark istatistiksel olarak anlamlıydı (p

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Cite This Article

DOĞRU, O., KOKSAL, H., KARANİS, M. İ. E., NAZİK, E. E., TURAN, E., ULUSOY, U. (2022). Are Peripheral Blood Derived Inflammation Markers Prognostic Indicators in Breast Cancer?. Gazi Medical Journal, Cilt: 28 - Sayı: 1, 39–41. https://ajindex.com/articles/519874

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References (1)

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