Case Series of Congenital Cytomegalovirus Infection in Neonatal Period

Key Findings & Data:CMV infection is a multisystem disease,which symptomatic infants generally present with intrauterine growthrestriction, hepatosplenomegaly, cholestasis, rash, thrombocytopenia, andmicrocephaly.Methods: Retrospective chart review was performed for newborns who werediagnosed with congenital CMV infection at tertiary neonatal intensive careunit (NICU) in Turkey, between October 2012 and January 2015.Results: We identified eight cases with congenital CMV infection with anincidence of 0.15 % among admitted neonates.

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Conclusion & Impact:Physicians should be aware of the preventivemeasures and postnatal interventions of congenital CMV infection.

🔬Design:Review & Systematic Survey

📍Scope:2012 Verileri

⚙️Variables:Domain Parameters

Abstract

Objective: Cytomegalovirus (CMV) is one of the most common cause ofcongenital infections in the newborn. CMV infection is a multisystem disease,which symptomatic infants generally present with intrauterine growthrestriction, hepatosplenomegaly, cholestasis, rash, thrombocytopenia, andmicrocephaly.Methods: Retrospective chart review was performed for newborns who werediagnosed with congenital CMV infection at tertiary neonatal intensive careunit (NICU) in Turkey, between October 2012 and January 2015.Results: We identified eight cases with congenital CMV infection with anincidence of 0.15 % among admitted neonates. Mean gestational age and birthweight of cases were 32.6 (±4.2) weeks and 1591 (±681) g respectively. Six(75%) cases were premature. The symptoms at presentation were as follows;thrombocytopenia, cholestatic hepatitis, blue-berry muffin rash, intracranialcalcification, microcephaly, pneumonia, and bilateral cataract. Five cases weretreated with ganciclovir. Three of them died in follow-up.Conclusion: Congenital CMV infection is an important cause of neonatalmorbidity and mortality. Physicians should be aware of the preventivemeasures and postnatal interventions of congenital CMV infection.

Özet

Amaç: Sitomegalovirus (CMV) yenidoğanda konjenital enfeksiyonların en yaygın nedenidir. CMV enfeksiyonu semptomatik infantlarda genellikle intrauterin büyüme geriliği, hepatosplenomegali, kolestaz, döküntü, trombositopeni ve mikrosefali ile bulgu veren olan multisistemik bir hastalıktır. Yöntem: Ekim 2012 ve Ocak 2015 yılları arasında, 3. düzey yenidoğan yoğun bakım ünitesinde konjenital CMV tanısı alan olguların verileri retrospektif olarak değerlendirildi. Bulgular: Çalışma süresince 8 olgu konjenital CMV tanısı aldı. Yoğun bakım ünitesine kabul edilen yenidoğanlar arasında konjenital CMV insidansı % 0, 15 olarak belirlendi. Olguların ortalama doğum haftası ve doğum ağırlığı 32, 6 (±4, 2) hafta ve 1591 (±681) gramdı. Altı (%75) olgu premature idi. Olguların tanı anında bulguları trombositopeni, kolestatik hepatit, blue-berry muffin döküntüsü, intrakraniyal kalsifikasyon, mikrosefali, pnömoni and bilateral katarakttı. Beş olguya gansiklovir ile tedavi başlandı. Üç olgu izlemde exitus oldu. Sonuç: Konjenital CMV enfeksiyonu neonatal morbidite ve mortalitenin önemli bir nedenidir. Doktorlar konjenital CMV enfeksiyonunu önleyici yaklaşımların ve doğum sonrası müdahalelerin farkında olmalıdır.

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Cite This Article

BAŞ, A. Y., DEMİREL, N., ÇELİK, İ. H., ÜNAL, S., ÖZCAN, B., IŞIK, D. U. (2022). Case Series of Congenital Cytomegalovirus Infection in Neonatal Period. Gazi Medical Journal, Cilt: 29 - Sayı: 1, 31–33. https://ajindex.com/articles/519822

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