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Journals / Gaziantep Medical Journal / 2015 / Cilt: 21 - Sayı: 2

Çocukluk çağı akut lenfoblastik lösemi radiyoterapisi sonrası gelişen gliyoblastoma: Derleme

Glioblastoma after radiotherapy for childhood acute lymphoblastic leukemia: Review

Abdurahman KUZHAN
Pages
125–130
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The goal of this review is to discuss the possible risk factors for radiation-induced tumorgenesis and histopathological characteristics.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Induction of neoplasia after therapeutic irradiation is well recognized.
📊
Key Findings & Data:The development of the glioblastoma has been documented less frequently in association with radiation therapy.
💡
Conclusion & Impact:The goal of this review is to discuss the possible risk factors for radiation-induced tumorgenesis and histopathological characteristics.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Induction of neoplasia after therapeutic irradiation is well recognized. The development of the glioblastoma has been documented less frequently in association with radiation therapy. Pediatric patients with acute lymphoblastic leukemia are more susceptible to radiation-induced complications than adult patients. Postradiation glioblastomas in childhood acute lymphoblastic leukemia have poor prognosis. Treating postradiation glioblastomas are challenging for pediatric neuro-oncologists because of their more aggressive course than primary glioblastomas. To improve survival ratios and quality of life new researches are required in this treatment field. The goal of this review is to discuss the possible risk factors for radiation-induced tumorgenesis and histopathological characteristics.

Özet

Radyasyon tedavisinin tümör gelişimine neden olduğu iyi bilinmektedir. Radyasyon tedavisi ilişkili gliyoblastom oluşumu çok az rapor edilmiştir. Akut lemfoblastik lösemili çocuk hastalar radyasyonun neden olduğu komplikasyonlara karşı yetişkinlerden daha duyarlıdır. Akut lemfoblastik lösemili çocuk hastalarda radyasyon tedavisi sonrası gelişen gliyoblastom olguları primer gliyoblastomaya göre kötü seyirlidir ve çok agresif davranışlı olduğundan dolayı nöro-onkologlar için tedavisi zordur. Bu hasta grubunun tedavisinde hayat kalitesini ve sağ kalımı artırmak için yeni araştırmalar gerekir. Bu derlemenin amacı gliyoblastomanın histopatolojik karakteristik özelliklerini ve radyasyonun tümörogeneze neden olan risk faktörlerini literatür eşliğinde tartışmaktır.

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Cite This Article

KUZHAN, A. (2022). Çocukluk çağı akut lenfoblastik lösemi radiyoterapisi sonrası gelişen gliyoblastoma: Derleme. Gaziantep Medical Journal, Cilt: 21 - Sayı: 2, 125–130. https://ajindex.com/articles/518808

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