Journals / Forbes tıp dergisi (Online) / 2021 / Cilt: 2 - Sayı: 3

Effects of Endogen Erythropoietin on Parathormone Secretion

Endojen Eritropoietinin Parathormon Salgısı Üzerine Etkileri

Pages
171–174
Publication Date
2022-10-19
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The paired t-test was used to detect the differences between serial concentrations of parathyroid hormone, erythropoietin, calcium, and phosphorus levels before and after ischemia, where “p values” of

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: We hypothesize that tissue hypoxia would increase erythropoietin, as well as parathormone (PTH), secretion.
📊
Key Findings & Data:Methods: This study included 20 patients who underwent orthopedic surgery with a pneumatic tourniquet, wherein, 6 had diagnostic arthroscopy and 14 had anterior cruciate ligament reconstruction.
💡
Conclusion & Impact:The paired t-test was used to detect the differences between serial concentrations of parathyroid hormone, erythropoietin, calcium, and phosphorus levels before and after ischemia, where “p values” of
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: We hypothesize that tissue hypoxia would increase erythropoietin, as well as parathormone (PTH), secretion. To verify this hypothesis, patients who had undergone orthopedic surgery with a pneumatic tourniquet were evaluated for endogenous tissue hypoxia. Methods: This study included 20 patients who underwent orthopedic surgery with a pneumatic tourniquet, wherein, 6 had diagnostic arthroscopy and 14 had anterior cruciate ligament reconstruction. All operations were performed under spinal anesthesia. The paired t-test was used to detect the differences between serial concentrations of parathyroid hormone, erythropoietin, calcium, and phosphorus levels before and after ischemia, where “p values” of

Özet

Amaç: Hipotezimiz, doku hipoksisinin parathormon (PTH) kadar eritropoietin salgısını da artıracağıydı. Bu hipotezi doğrulamak için pnömatik turnike ile ortopedik cerrahi geçiren hastalar endojen doku hipoksisi açısından değerlendirildi. Yöntem: Bu çalışmaya pnömatik turnike ile ortopedik cerrahi uygulanan 20 hasta dahil edildi. Altısına tanısal artroskopi, 14’üne ön çapraz bağ rekonstrüksiyonu yapıldı. Ameliyatların tamamı spinal anestezi altında yapıldı. Paratiroid hormonu, eritropoietin, kalsiyum ve fosfor düzeylerinin iskemi öncesi ve sonrasındaki seri konsantrasyonları arasındaki farkların saptanması için eşleştirilmiş t-testini kullandık, burada “p değerlerinin”

🔖

Cite This Article

ATMACA, M., GÖNÜLLÜ, E., ÖZBAY, M. F., ÖZKAN, S., ADANAŞ, C., KILIÇ, E. (2022). Effects of Endogen Erythropoietin on Parathormone Secretion. Forbes tıp dergisi (Online), Cilt: 2 - Sayı: 3, 171–174. https://ajindex.com/articles/517904

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Liboi E, Carroll M, D'Andrea AD, Mathey-Prevot B. Erythropoietin receptor signals both proliferation and erythroid-specific differentiation. Proc Natl Acad Sci U S A. 1993;90:11351-5
  2. Rózsás A, Berta J, Rojkó L, et al. Erythropoietin receptor expression is a potential prognostic factor in human lung adenocarcinoma. PLoS One. 2013;8:e77459
  3. Ogunshola OO, Bogdanova AY. Epo and non-hematopoietic cells: what do we know? Methods Mol Biol. 2013;982:13-41
  4. Oztürk M, Ustek D, Akbas F, et al. The presence of erythropoietin receptor in parathyroid cells. J Endocrinol Invest. 2007;30:RC35-7
  5. Atmaca M, Tasdemir E. Corelation of parathyroid hormone and hemoglobin levels in normal renal function. Acta Endocrinologica (Buc). 2011;7:317-23
  6. Kokot F, Nieszporek T, Wiecek A, Skrzypek J, Ziemiańczyk S, Jarzab B. Stezenie erytropoetyny w surowicy u chorych na pierwotna nadczynność przytarczyc [levels of erythropoietin in serum of patients with primary hyperparathyroidism]. Pol Arch Med Wewn. 1995;93:209-15
  7. Haase VH. Regulation of erythropoiesis by hypoxia-inducible factors. Blood Rev. 2013;27:41-53
  8. Cushing H. Pneumatic tourniquets: with especial reference to their use in craniotomies. Med News. 1904;84:577-80
  9. Sharrock NE, Savarese JJ. Anesthesia for orthopedic surgery. In: Miller RD, ed. Anesthesia. 5th ed. New York: Churchill Livingston, 2000;2118-36
  10. Ostman B, Michaelsson K, Rahme H, Hillered L. Tourniquet-induced ischemia and reperfusion in human skeletal muscle. Clin Orthop Relat Res. 2004;(418):260-5
  11. Rao DS, Shih MS, Mohini R. Effect of serum parathyroid hormone and bone marrow fibrosis on the response to erythropoietin in uremia. N Engl J Med. 1993;328:171-5
  12. Cikrikcioglu MA, Karatoprak C, Cakirca M, et al. Association of calcium channel blocker use with lower hemoglobin levels in chronic kidney disease. Eur Rev Med Pharmacol Sci. 2013;17:2530-7
  13. Levi J, Bessler H, Hirsch I, Djaldetti M. Increased RNA and heme synthesis in mouse erythroid precursors by parathyroid hormone. Acta Haematol. 1979;61:125-9
  14. Meytes D, Bogin E, Ma A, Dukes PP, Massry SG. Effect of parathyroid hormone on erythropoiesis. J Clin Invest. 1981;67:1263-9
  15. Komatsuda A, Hirokawa M, Haseyama T, et al. Human parathyroid hormone does not influence human erythropoiesis in vitro. Nephrol Dial Transplant. 1998;13:2088-91
  16. Delwiche F, Garrity MJ, Powell JS, Robertson RP, Adamson JW. High levels of the circulating form of parathyroid hormone do not in