Journals / Fiziksel Tıp ve Rehabilitasyon Bilimleri Dergisi / 2022 / Cilt: 25 - Sayı: 2

Evaluation of Functional, Cognitive and Emotional Outcomes and Pituitary Hormones According to Trauma Severity in Patients with Traumatic Brain Injury

Travmatik Beyin Hasarı Olan Hastalarda Travma Şiddetine Göre Fonksiyonel, Bilişsel ve Emosyonel Sonuçların ve Hipofiz Hormon Düzeylerinin Değerlendirilmesi

Pages
150–157
Publication Date
2022-10-18
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, assigning the GCS score is valuable in the subsequent rehabilitation process, especially in terms of determining clinical results.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: To compare the anterior pituitary hormone levels, functional, cognitive, and emotional outcomes in adult patients with chronic period moderate or severe traumatic brain injury (TBI) and to determine the relationship between these parameters and the severity of trauma.
📊
Key Findings & Data:Trauma severity was determined according to the Glasgow Coma Scale (GCS) score recorded within the first 24 hours, and the patients were divided into 2 groups as moderate (n=20) and severe TBI (n=33).
💡
Conclusion & Impact:Therefore, assigning the GCS score is valuable in the subsequent rehabilitation process, especially in terms of determining clinical results.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: To compare the anterior pituitary hormone levels, functional, cognitive, and emotional outcomes in adult patients with chronic period moderate or severe traumatic brain injury (TBI) and to determine the relationship between these parameters and the severity of trauma. Material and Methods: Fifty-three patients with TBI were included in this cross-sectional study. Trauma severity was determined according to the Glasgow Coma Scale (GCS) score recorded within the first 24 hours, and the patients were divided into 2 groups as moderate (n=20) and severe TBI (n=33). Functional Independence Measure (FIM), Mini Mental State Test (MMST), Ranchos Los Amigos Cognitive Function Scale (RLAS), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were used for evaluations. Basal levels of adrenocorticotropic hormone, prolactin, follicle stimulating hormone, luteinizing hormone, thyroid stimulating hormone, insulin-like growth factor-1 and growth hormone were measured in all patients. Results: There was a significant difference between patients with moderate and severe TBI in terms of FIM, MMST, BDI and BAI values but no difference was found in anterior pituitary hormone basal levels. There was a positive relationship between GCS score and FIM and MMST, and a negative relationship between BDI and BAI while no relationship was noted between GCS score and anterior pituitary basal hormone levels. Conclusion: In patients with chronic TBI, dependence in daily living activities, depressive mood, anxiety and deterioration in cognitive functions increase as the severity of trauma increases. Therefore, assigning the GCS score is valuable in the subsequent rehabilitation process, especially in terms of determining clinical results.

Özet

Amaç: Kronik dönem orta veya ağır travmatik beyin hasarı (TBH) olan erişkin hastalarda ön hipofiz hormon düzeylerini, fonksiyonel, bilişsel ve emosyonel sonuçları karşılaştırmak, bu parametrelerin travma şiddeti ile ilişkisini belirlemek hedeflenmiştir. Gereç ve Yöntemler: Kesitsel olarak planlanan bu çalışmaya en az 6 aydır TBH’li olan 53 hasta dâhil edildi. Travma şiddeti ilk 24 saat içinde kaydedilen Glaskow Koma Skalası (GKS) skoruna göre belirlendi, hastalar orta (n=20) ve ağır TBH (n=33) olarak 2 gruba ayrıldı. Fonksiyonel Bağımsızlık Ölçeği (FBÖ), Mini Mental Durum Testi (MMDT), Ranchos Los Amigos Kognitif Fonksiyon Skalası (RLAS), Beck Depresyon Ölçeği (BDÖ) ve Beck Anksiyete Ölçeği (BAÖ) değerlendirmeler için kullanıldı. Ayrıca tüm hastaların adrenokortikotropik hormon, prolaktin, folikül uyarıcı hormon, luteinize edici hormon, tiroid uyarıcı hormon, insülin benzeri büyüme faktörü-1 ve büyüme hormon bazal seviyeleri ölçüldü. Bulgular: Orta ve ağır TBH olan hastalar arasında FBÖ, MMDT, BDÖ ve BAÖ değerleri bakımından anlamlı farklılık vardı ancak ön hipofiz hormon bazal düzeyleri farklılık göstermedi. GKS ile FBÖ ve MMDT arasında pozitif ilişki, BDÖ ve BAÖ arasında negatif ilişki görülürken ön hipofiz hormon düzeyleri ile ilişki saptanmadı. Sonuç: Kronik TBH olan hastalarda travmanın şiddeti arttıkça günlük yaşam aktivitelerinde bağımlılık, depresif duygudurum, anksiyete ve bilişsel işlevlerde bozulma artmaktadır. Bu nedenle, GKS skorunun kaydedilmesi, sonraki rehabilitasyon sürecinde, özellikle klinik sonuçların belirlenmesi açısından değerlidir.

🔖

Cite This Article

ASLAN, S. G., GÜRÇAY, E., SABUNCU, T., KORKMAZ, N., TEZEN, Ö., YAŞAR, E. (2022). Evaluation of Functional, Cognitive and Emotional Outcomes and Pituitary Hormones According to Trauma Severity in Patients with Traumatic Brain Injury. Fiziksel Tıp ve Rehabilitasyon Bilimleri Dergisi, Cilt: 25 - Sayı: 2, 150–157. https://ajindex.com/articles/516718

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Tanriverdi F, Schneider HJ, Aimaretti G, et al. Pituitary dysfunction after traumatic brain injury: a clinical and pathophysiological approach. Endocr Rev. 2015
  2. [Crossref] [PubMed] 2. Stocchetti N, Zanier ER. Chronic impact of traumatic brain injury on outcome and quality of life: a narrative review. Crit Care. 2016
  3. [Crossref] [PubMed] [PMC] 3. Aimaretti G, Ambrosio MR, Di Somma C, et al. Residual pituitary function after brain injury-induced hypopituitarism: a prospective 12- month study. J Clin Endocrinol Metab. 2005
  4. [Crossref] [PubMed] 4. Tanriverdi F, Ulutabanca H, Unluhizarci K, et al. Three years prospective investigation of anterior pituitary function after traumatic brain injury: a pilot study. Clin Endocrinol (Oxf). 2008
  5. [Crossref] [PubMed] 5. Lauzier F, Turgeon AF, Boutin A, et al. Clinical outcomes, predictors, and prevalence of anterior pituitary disorders following traumatic brain injury: a systematic review. Crit Care Med. 2014
  6. [Crossref] [PubMed] 6. Tan CL, Alavi SA, Baldeweg SE, et al. The screening and management of pituitary dysfunction following traumatic brain injury in adults: British Neurotrauma Group guidance. J Neurol Neurosurg Psychiatry. 2017
  7. [Crossref] [PubMed] [PMC] 7. Agha A, Thompson CJ. Anterior pituitary dysfunction following traumatic brain injury (TBI). Clin Endocrinol (Oxf). 2006
  8. [Crossref] [PubMed] 8. Pavlovic D, Pekic S, Stojanovic M, et al. Chronic cognitive sequelae after traumatic brain injury are not related to growth hormone deficiency in adults. Eur J Neurol. 2010
  9. [Crossref] [PubMed] 9. Teasdale G, Maas A, Lecky F, et al. The Glasgow Coma Scale at 40 years: standing the test of time. Lancet Neurol. 2014
  10. Erratum in: Lancet Neurol. 2014
  11. [Crossref] [PubMed] 10. Maas AIR, Menon DK, Adelson PD, et al
  12. InTBIR Participants and Investigators. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. Lancet Neurol. 2017
  13. [PubMed] 11. Pavlovic D, Pekic S, Stojanovic M, et al. Traumatic brain injury: neuropathological, neurocognitive and neurobehavioral sequelae. Pituitary. 2019
  14. [Crossref] [PubMed] 12. Doğan K, Seyithanoğlu MH, Özkan N ve ark. Kafa travmasının akut döneminde hipofiz fonksiyonlarının değerlendirilmesi [Evaluation of the pituitary functions during acute phase of head trauma]. Kafkas J Med Sci. 2012
  15. [Crossref] 13. Kidd D, Stewart G,