A Neuroacanthocytosis Case with Mcleod Syndrome and Depression

Objective & Hypothesis:Neuroacanthocytosis syndromes are characterized by detection of acanthocytes in peripheral blood smear with variable age of onset, and multisystemic effects especially on the central nervous system and particularly progressive degeneration of the basal ganglia.

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Key Findings & Data:In this case we report a patient presenting involuntary biting of his cheek admitted to our hospital neurology inpatient clinic, was consulted by us because of the possible psychogenic cause of the symptom and was operated because of developed dysplasia due to probable biting of the lips 1 year ago and putting many substances such as piece of cloth, chewing gum in her mouth to prevent bites.

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Conclusion & Impact:We aimed to discuss the neuropsychiatric symptoms and treatment strategies of the symptoms that can be seen in acanthocytosis syndromes

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Neuroacanthocytosis syndromes are characterized by detection of acanthocytes in peripheral blood smear with variable age of onset, and multisystemic effects especially on the central nervous system and particularly progressive degeneration of the basal ganglia. McLeod is one of the genetic based neuroacanthocytosis syndrome that can lead to a variety of neuropsychiatric symptoms in patients. In this case we report a patient presenting involuntary biting of his cheek admitted to our hospital neurology inpatient clinic, was consulted by us because of the possible psychogenic cause of the symptom and was operated because of developed dysplasia due to probable biting of the lips 1 year ago and putting many substances such as piece of cloth, chewing gum in her mouth to prevent bites. In her clinical follow-up development of depressive symptoms was observed and partially successful treatment of depressive symptoms and involuntary cheek biting was performed with aripiprazole 10 mg/day. We aimed to discuss the neuropsychiatric symptoms and treatment strategies of the symptoms that can be seen in acanthocytosis syndromes

Özet

Nöroakantositoz sendromları periferik yaymada akantositlerle karakterize başlangıç yaşı değişken vücutta birçok sistemi etkileyebilmekle birlikte santral sinir sisteminde özellikle bazal ganglionlarda dejenerasyonla giden ilerleyici bir grup hastalığa verilen addır. Mc Leod sendromu da genetik nöroakantositoz sendromlarından biri olup hastalarda çeşitli nöropsikiyatrik belirtilere yol açabilmektedir. Bu vaka sunumunda hastanemiz nöroloji kliniğinde ağızda istemsiz ısırmaları olup bunların psikojenik olduğu düşünülerek tarafımıza konsülte edilen; 1 yıl önce dudağında muhtemel bu ısırmalara bağlı displazi gelişip opere edilen ve devam eden ısırmaları önlemek için ağzına bez parçası, çok sayıda sakız gibi maddeler koyan, klinik takipte depresif belirtileri gelişen aripiprazol 10 mg tedavisi ile yanağını ısırmasının ve depresif belirtilerinin kısmen azaldığı bir vaka üzerinden nöroakantositoz sendromları, bu sendromlarda görülebilecek nöropsikiyatrik belirtiler ve tedavi stratejilerinin tartışılması amaçlanmıştır

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Cite This Article

ÖZCAN, H., YÜCEL, A., ÖZEL, L., ÖZDEMİR, G. (2022). A Neuroacanthocytosis Case with Mcleod Syndrome and Depression. Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi, Cilt: 29 - Sayı: 1, 47–50. https://ajindex.com/articles/514620

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