Journals / Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi / 2016 / Cilt: 30 - Sayı: 1

A Case with Toxic Epidermal Necrolysis Triggered By 5-Fluorouracil

5-Florourasile Bağlı Gelişen Toksik Epidermal Nekrolizis Vakası

Pages
21–24
Publication Date
2022-10-18
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

TEN secondary to 5 fluorouracil treatment is rarely seen and has not been previously reported in adolescents.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:5 Fluorouracil is widely used in the treatment of solid tumors.
📊
Key Findings & Data:The adverse skin reactions due to 5 fluorouracil drugs are photosensitivity, hyperpigmentation, actinic keratosis, flaring of seborrheic dermatitis, palmoplantar erythrodysesthesis and less frequently toxic epidermal necrolysis (TEN).
💡
Conclusion & Impact:TEN secondary to 5 fluorouracil treatment is rarely seen and has not been previously reported in adolescents.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

5 Fluorouracil is widely used in the treatment of solid tumors. The adverse skin reactions due to 5 fluorouracil drugs are photosensitivity, hyperpigmentation, actinic keratosis, flaring of seborrheic dermatitis, palmoplantar erythrodysesthesis and less frequently toxic epidermal necrolysis (TEN). Toxic epidermal necrolysis is defined as the detachment of more than 30% of body surface area with high risk of multiple organ failure and eventually death. Toxic epidermal necrolysis has high mortality and requires urgent medical treatment. We want to report a case diagnosed with 5-fluorouracil induced TEN and died with multi-organ failure. TEN secondary to 5 fluorouracil treatment is rarely seen and has not been previously reported in adolescents.

Özet

5 Florourasil solit tümörlerin tedavisinde yaygın olarak kullanılmaktadır. 5-Florourasil'e bağlı deri reaksiyonları; fotosensitivite, hiperpigmentasyon, aktinik kerotozis, seboraik dermatitin alevlenmesi, palmar plantar eritrodisestezi ve nadiren toksik epidermal nekrolizis (TEN) şeklinde izlenmektedir. TEN total vücut yüzey alanının %30'dan fazlasını içeren epidermisin dekolmanı ve takibinde multiorgan yetmezliğine neden olan, acil olarak tedavisine başlanması gereken ve yüksek mortalite ile seyreden bir durumdur. Burada sunulan vakada 5-florourasile bağlı nadir görülen bir durum olarak TEN gelişmiş ve hasta multiorgan yetmezliğinden kaybedilmiştir. Adölosan yaş grubunda 5 florourasile bağlı TEN gelişimi daha önce rapor edilmemiş olup nadir görülmesinden dolayı vaka rapor edildi.

🔖

Cite This Article

BAHADIR, A., ERDURAN, E., ABUL, M. H. (2022). A Case with Toxic Epidermal Necrolysis Triggered By 5-Fluorouracil. Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi, Cilt: 30 - Sayı: 1, 21–24. https://ajindex.com/articles/514579

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Liu XQ, Zhuang M, Wang Z, et al. Correlation between dihydropyrimidine dehydrogenase and efficacy and toxicity of fluoropyrimidine drugs. European Review for Medical and pharmacological sciences 2014; 18: 2772-2776
  2. Pujol RM, Rocamora V, Lopez-Pousa A, et al. Persistent supravenous erythematous eruption: A rare local complication of intravenous 5-fluorouracil therapy. Journal of the American Academy of Dermatology. 1998; 39: 839- 842
  3. Nadal C, Pujol RM, Randazzo L, et al. Systemic contact dermatitis from 5-fluorouracil. Contact Dermatitis 1996; 35: 124-125
  4. Bastuji-Garin S, Rzany B, Stern RS, et al. Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme. Archives of Dermatology 1993; 129: 92-96
  5. Saeed H, Mantagos IS, Chodosh J. Complications of Stevens-Johnson syndrome beyond the eye and skin. Burns 2016; 42: 20-27
  6. Sommers KR, Kong KM, Bui DT, et al. Stevens-Johnson syndrome/toxic epidermal necrolysis in a patient receiving concurrent radiation and gemcitabine. Anti-cancer Drugs 2003; 14: 659-662
  7. Tristani-Firouzi P, Petersen MJ, Saffle JR, et al. Treatment of toxic epidermal necrolysis with intravenous immunoglobulin in children. Journal of the American Academy of Dermatology 2002; 47: 548-552
  8. Barron SJ, Del Vecchio MT, Aronoff SC. Intravenous immunoglobulin in the treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis: A meta-analysis with meta-regression of observational studies. International Journal of Dermatology 2015; 54: 108-115
  9. Paci A, Veal G, Bardin C, et al. Review of therapeutic drug monitoring of anticancer drugs part 1--cytotoxics. Eur J Cancer 2014; 50: 2010-2019
  10. Falvella FS, Caporale M, Cheli S, et al. Undetected toxicity risk in pharmacogenetic testing for dihydropyrimidine dehydrogenase. International Journal of Molecular Sciences 2015; 16: 8884-8895.