Journals / Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi / 2016 / Cilt: 30 - Sayı: 2

Determination of the Effects of Acute Exercise On Creatine Kinase, Creatine Kinase-Myocardial Isoenzyme Levels in Sedentary Male Subjects

Akut Egzersizin Sedanter Deneklerde Kreatin Kinaz, Kreatin Kinaz-Miyokard İzoenzimi Seviyesi Üzerine Olan Etkisinin İncelenmesi

Pages
51–55
Publication Date
2022-10-18
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

During exercise, CK-MB level, as evaluated in terms of percent change is increased more than CK levels Conclusion: These results indicated that exercise induced muscle injury significantly increases CK, CK-MB levels.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Creatine kinase (CK) is an enzyme that is expressed in higher proportions in skeletal and heart muscle, lower concentration in brain tissue.
📊
Key Findings & Data:Materials and Methods: Total of 50 male subjects were participated.
💡
Conclusion & Impact:During exercise, CK-MB level, as evaluated in terms of percent change is increased more than CK levels Conclusion: These results indicated that exercise induced muscle injury significantly increases CK, CK-MB levels.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Creatine kinase (CK) is an enzyme that is expressed in higher proportions in skeletal and heart muscle, lower concentration in brain tissue. It may be used to determine injury of skeletal and heart muscle. Creatine kinase-myocardial isoenzyme (CK-MB) is a good indicator that is used by the diagnosis for myocardial infarcts and also inflammatory skeletal muscle diseases. The aim of this study was to examine the effects of acute exercise on CK, CK-MB levels in sedentary male subjects. Thus, exercise induced muscle injury levels will be determined. Materials and Methods: Total of 50 male subjects were participated. Subjects performed an acute aerobic exercise work load corresponded to 50-80% of maximal heart rate. Venous blood samples were drawn before and at the end of the exercise. CK, CK-MB levels were measured using autoanalyser. Results: CK and CK-MB levels were both increased significantly in all subjects. During exercise, CK-MB level, as evaluated in terms of percent change is increased more than CK levels Conclusion: These results indicated that exercise induced muscle injury significantly increases CK, CK-MB levels. The observation of higher increases in CK-MB levels during acute exercise may reveal the heart muscle injury.

Özet

Amaç: Kalp ve iskelet kasında daha yüksek oranlarda bulunan kreatin kinaz (CK); beyin dokusunda daha düşük konsantrasyonlarda bulunan bir enzimdir. İskelet kası ile kalp kası hasarının belirlenmesinde kullanılmaktadır. Miyokard infarktüsü tanısında kullanılan kreatin kinazmiyokard izoenzimi (CK-MB) buna ek olarak inflamatuar iskelet kası hastalıkları için de güvenilir bir göstergedir. Bu çalışmanın amacı; sedanter erkek bireylerde akut egzersizin CK, CK-MB düzeyine olan etkilerini incelemektir. Böylece egzersizin neden olduğu kas hasarı düzeyi belirlenecektir. Gereç ve Yöntem: Bu çalışmaya 50 erkek denek katılmıştır. Denekler maksimal kalp atım seviyelerinin %50-80 arasında akut aerobik egzersiz yapmışlardır. Venöz kan örnekleri egzersizden önce ve egzersizin sonunda alınmıştır. CK, CK-MB düzeyleri otoanalizörlerle ölçülmüştür. Bulgular: Çalışmaya katılan deneklerde hem CK hem de CK-MB düzeylerinde anlamlı artışlar belirlenmiştir. Yüzde değişim açısından; egzersiz boyunca CK-MB düzeyinin CK düzeyinden daha yüksek oranda arttığı belirlenmiştir. Sonuç: Bu sonuçlar akut egzersizin CK ve CK-MB düzeyinin anlamlı oranda artırdığını ve kas hasarına neden olduğunu göstermektedir. Akut egzersiz sırasında CK-MB düzeyinde daha fazla artışın görülmesi egzersizin kalp kası hasarına daha fazla neden olabileceğini düşündürmektedir.

🔖

Cite This Article

ÖZÇELİK, O., ALGÜL, S. (2022). Determination of the Effects of Acute Exercise On Creatine Kinase, Creatine Kinase-Myocardial Isoenzyme Levels in Sedentary Male Subjects. Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi, Cilt: 30 - Sayı: 2, 51–55. https://ajindex.com/articles/514572

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Schlattner U, Tokarska-Schlattner M, Wallimann T. Mitochondrial creatine kinase in human health and disease. Biochim Biophys Acta 2006; 1762: 164-180.
  2. Skitek M, Kranjec I, Jerin A. Glycogen phosphorylase isoenzyme BB, creatine kinase isoenzyme MB and troponin I for monitoring patients with percutaneous coronary intervention a pilot study. Med Glas (Zenica) 2014; 11: 13-18.
  3. Brancaccio P, Limongelli FM, Maffulli N. Monitoring of serum enzymes in sport. Br J Sports Med 2006; 40: 96-97.
  4. Stomme JH, Rustad P, Steensland H, Theodorsen L, Urdal P. Reference intervals for eight enzymes in blood of adult females and males measured in accordance with the international Federation of Clinical Chemistry reference system at 378C: Part of the Nordic Reference Interval Project. Scand J Clin Lab Invest 2004; 64: 371-384.
  5. Grobben RB, Nathoe HM, Januzzi JL Jr, van Kimmenade RR. Cardiac markers following cardiac surgery and percutaneous coronary intervention. Clin Lab Med 2014; 34: 99-111.
  6. Wasserman K, Hansen JE, Sue DY, Stringer W, Whipp BJ. Principles of Exercise Testing and Interpretation: Including Pathophysiology and Clinical Applications. 5th Edition.
  7. New York, NY, USA: Lippincott Williams & Wilkins, 2012.
  8. Duttaroy S, Thorell D, Karlsson L, Börjesson M. A single- bout of one-hour spinning exercise increases troponin T in healthy subjects. Scand Cardiovasc J 2012; 46: 2-6.
  9. Brancaccio P, Maffulli N, Limongelli FM. Creatine kinase monitoring in sport medicine. Br Med Bull 2007; 81-82: 209-230.
  10. Kaya H, Ozcelik O. Tıp öğrencilerinde bir yılda vücut kompozisyonlarında belirlenmesi. Fırat Tıp Derg 2005; 10: 164-168. gelen değişimlerin Karvonen MJ, Kentala E, Mustala O. The effects of training on heart rate: A longitudinal study. Ann Med Exp Biol Fenn 1957; 35: 307-315.
  11. Lounana J, Campion F, Noakes TD, Medelli J. Relationship between % HRmax, % HR reserve, %VO2 max, and %VO2 reserve in elite cyclists. Med Sci Sports Exerc 2007; 39: 350-357.
  12. Chen TC, Hsieh SS. Effects of a 7-day eccentric training period on muscle damage and inflammation. Med Sci Sports Exerc 2001; 33: 1732-1738.
  13. Dousset E, Avela J, Ishikawa M, et al. Bimodal recovery pattern in human skeletal muscle induced by exhaustive stretch- shortening cycle exercise. Med Sci Sports Exerc 2007; 39: 453-460.
  14. Hazar S, Hazar M, Korkmaz Ş, Bayil S, Gürkan CA. The effects of graded maximal aerobic exercise on some metabolic hormones, muscle damage and some metabolic and products in sportsmen. Sci Res Essays 2011; 6: 1337- 1343.