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Journals / Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi / 2019 / Cilt: 33 - Sayı: 3

Comparison of the Effects of Immobilization Stress and Chronic Mild Stress Models on Depression-Related Behaviors in Female Rats: An Assessment of a 10-Day Stress Period

İmmobilizasyon Stresi ve Kronik Hafif Stres Modellerinin Dişi Sıçanlarda Depresyon Benzeri Davranışlar Üzerine Etkilerinin Kıyaslanması: 10 Günlük Stres Süresinin Değerlendirmesi

Hatice SOLAK
Aynur KOÇ
Raviye ÖZEN KOCA
Selim KUTLU
Alpaslan ÖZKÜRKÇÜLER
Zafer ŞAHİN
Ömer Faruk KALKAN
Pages
153–157
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Results: In the forced swimming test, immobility behavior in the immobilization stress group and chronic mild stress group was significantly higher than the control group (P

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This study was designed to compare the depression-related behavior-inducing potentials of 10-day immobilization stress and chronic mild stress in adult female rats.
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Key Findings & Data:Materials and Methods: Adult Wistar rats were randomly divided into three groups (n=10) as control, immobilization stress (45 minutes per day) and chronic mild stress.
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Conclusion & Impact:Results: In the forced swimming test, immobility behavior in the immobilization stress group and chronic mild stress group was significantly higher than the control group (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: This study was designed to compare the depression-related behavior-inducing potentials of 10-day immobilization stress and chronic mild stress in adult female rats. Materials and Methods: Adult Wistar rats were randomly divided into three groups (n=10) as control, immobilization stress (45 minutes per day) and chronic mild stress. Both stress protocols were applied for a period of 10 days. Behavioral tests were performed when the rats were in diestrus. Results: In the forced swimming test, immobility behavior in the immobilization stress group and chronic mild stress group was significantly higher than the control group (P

Özet

Amaç: Bu çalışmada 10 gün süresince uygulanan immobilizasyon stresi ve kronik hafif stres modellerinin erişkin dişi sıçanlarda depresyonla ilişkili davranışları indükleme potansiyellerinin kıyaslanması amaçlanmıştır. Gereç ve Yöntem: Yetişkin Wistar albino ırkı sıçanlar kontrol, immobilizasyon stresi (günlük 45 dakika) ve kronik hafif stres olarak rastgele üç gruba (n = 10) ayrılmıştır Her iki stres protokolü de 10 gün süresince uygulanmıştır. Davranış testleri sıçanlar döstrüs dönemindeyken gerçekleştirilmiştir. Bulgular: Zorunlu yüzme testinde, immobilizasyon stres grubundaki ve kronik hafif stres grubundaki hayvanlarda hareketsiz kalma/kendini bırakma davranış süreleri kontrol grubundan anlamlı olarak yüksekti (sırasıyla P

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Cite This Article

SOLAK, H., KOÇ, A., KOCA, R. Ö., KUTLU, S., ÖZKÜRKÇÜLER, A., ŞAHİN, Z., KALKAN, Ö. F. (2022). Comparison of the Effects of Immobilization Stress and Chronic Mild Stress Models on Depression-Related Behaviors in Female Rats: An Assessment of a 10-Day Stress Period. Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi, Cilt: 33 - Sayı: 3, 153–157. https://ajindex.com/articles/514481

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References (17)

  1. Belmaker RH, Agam G: Major depressive disorder. N Engl J Med 2008; 358: 55-68
  2. Mental Health Foundation. Fundamental Facts About Mental Health 2016. Mental Health Foundation: London, 2016
  3. Kessler RC, Berglund P, Demler O, et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA 2003; 289: 3095-3105
  4. Altemus M, Sarvaiya N, Neill Epperson C. Sex differences in anxiety and depression clinical perspectives. Front Neuroendocrinol 2014; 35: 320-330
  5. Albert PR. Why is depression more prevalent in women? J Psychiatry Neurosci 2015; 40: 219-221
  6. Austin MP, Kildea S, Sullivan E. Maternal mortality and psychiatric morbidity in the perinatal period: challenges and opportunities for prevention in the Australian setting. Med J Aust 2007; 186: 364-367
  7. Greenberg P, Corey-Lisle P, Birnbaum H, Marynchenko M, Claxton A. Economic implications of treatmentresistant depression among employees. Pharmacoeconomics 2004; 22: 363-373
  8. Cryan JF, Mombereau C. In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice. Mol Psychiatry 2004; 9: 326-357
  9. O'Neil MF, Moore NA. Animal models of depression: are there any? Hum Psychopharmacol 2003; 18: 239-354
  10. Stepanichev M, Dygalo NN, Grigoryan G, Shishkina GT, Gulyaeva N. Rodent models of depression: neurotrophic and neuroinflammatory biomarkers. Biomed Res Int 2014; 2014: 932757
  11. Krishnan V, Nestler EJ. Animal models of depression: molecular perspectives. Curr Top Behav Neurosci 2011; 7: 121-147
  12. Jaggi AS, Bhatia N, Kumar N, et al. A review on animal models for screening potential anti-stress agents. Neurol Sci 2011; 32: 993-1005
  13. Sahin Z, Koc A, Ozen Koca R, et al. Comparison of effects of three distinct stress models on anxiety- and depression-related behaviors in female rats. Sakarya Medical Journal 2019; 9: 131-140
  14. Willner P. The chronic mild stress (CMS) model of depression: History, evaluation and usage. Neurobiology of Stress 2017; 6: 78e93
  15. Solak H, Ozen Koca R, Koc A, et al. Effect of pregnancy and lactation period on depression like behaviour in depressive rats. Neuroendocrinology 2018; 107; 24-25
  16. Porsolt, RD, Le Pichon M, Jalfre M. Depression: A new animal model sensitive to antidepressant treatments. Nature 1977; 266: 730-732
  17. Prut L, Belzung C. The open field as a paradigSm to measure the effects of drugs on anxiety-like behaviors: a revi