Journals / Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi / 2020 / Cilt: 34 - Sayı: 2

The Effect of Preoperative Clopidogrel Use on Postoperative Bleeding in Patients with Emergency or Early Coronary Bypass Surgery

Preoperatif Klopidogrel Kullanımının Acil veya Erken Koroner Bypass Yapılan Hastalarda Postoperatif Kanama Üzerine Etkisi

Pages
155–160
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The drainage volume was significantly higher in the group without clopidogrel (P

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Bleeding is still a major problem after coronary artery bypass surgery (CABG), despite all the improvements.
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Key Findings & Data:Materials and Methods: In this study, between 2015 and 2017, we have compared 66 patients who had emergency CABG while clopidogrel treatment due to coronary artery disease with 68 patients who had elective CABG without clopidogrel in terms of the amount of bleeding, blood products and revisions needed.
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Conclusion & Impact:The drainage volume was significantly higher in the group without clopidogrel (P
🔬Design:Research Article
📍Scope:2015 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Bleeding is still a major problem after coronary artery bypass surgery (CABG), despite all the improvements. Antiplatelet drugs which are proven to reduce ischemic cardiac events are used very frequently. Nowadays, the number of patients, who need emergency CABG while clopidogrel treatment, are increasing. We investigated the effects of preoperative clopidogrel use on postoperative bleeding in emergency CABG. Materials and Methods: In this study, between 2015 and 2017, we have compared 66 patients who had emergency CABG while clopidogrel treatment due to coronary artery disease with 68 patients who had elective CABG without clopidogrel in terms of the amount of bleeding, blood products and revisions needed. Patients who had multiple procedures or additional cardiac diseases were excluded. Results: From the total 134 patients (n: 101) 75.4% were male and 24.6% (n: 33) were female. 49.3% (n: 66) of the patients were using clopidogrel, while 50.7% (n: 68) of them were not. The postoperative drainage was 410(150-1300) mL in group with clopidogrel, while it was 640(150- 2750) mL in the other group. The drainage volume was significantly higher in the group without clopidogrel (P

Özet

Amaç: Koroner arter bypass cerrahisinde tüm gelişmelere rağmen; kanama, önemli bir sorunolmaya devam etmektedir. İskemik kardiak olayları azalttıkları birçok klinik çalışmayla ispatlananantiagregan ilaçlar yoğun olarak kullanılmaktadır. Bu ilaçlardan klopidogrel kullanırken, acil veerken koroner arter bypass greftleme (KABG) ameliyatına alınan hasta grubu sayısı daartmaktadır. Bu çalışmada; preoperatif klopidogrel kullanımının acil ve erken KABG ameliyatıyapılan hastalarda, postopereatif kanama üzerine etkisini araştırıldı.Gereç ve Yöntem: Bu çalışmada farklı ekipler tarafından 2015–2017 tarihleri arasında ek kardiyakhastalığı olmayan ve ek cerrahi prosedür geçirmeyen, koroner arter hastalığı nedeniyle klopidogrelkullanırken acil ve erken operasyona alınan 66 hasta ile, klopidogrel kullanmayan, elektif şartlardaoperasyona alınan 68 hasta, kanama miktarı, kullanılan kan transfüzyonu türü ve miktarı, revizyonsayısına göre karşılaştırıldı.Bulgular: Çalışmamıza alınan 134 hastanın %75.4’ü (n:101) erkek, %24.6’sı (n:33) kadındı.Hastaların %49.3’ü (n:66) klopidogrel kullanıyor, %50.7’si (n:68) klopidogrel kullanmıyordu.klopidogrel kullanan grubun postop drenaj miktarı 410(150-1300) mL iken, diğer grubun postopdrenaj miktarı 640(150-2750) mL idi. Klopidogrel kullanmayan grupta, postop drenaj miktarıistatistiksel olarak anlamlı düzeyde daha yüksek bulunmuştur (P

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Cite This Article

YEŞİLTAŞ, M. A., ÖZSOY, S. D., UYSAL, A., HABERAL, İ., CÖHCEN, S. (2022). The Effect of Preoperative Clopidogrel Use on Postoperative Bleeding in Patients with Emergency or Early Coronary Bypass Surgery. Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi, Cilt: 34 - Sayı: 2, 155–160. https://ajindex.com/articles/514441

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