Journals / European Journal of Therapeutics / 2018 / Cilt: 24 - Sayı: 1

Effect of Helicobacter pylori Infection on Duodenitis in Patients with Dyspepsia

Dispepsisi Olan Hastalarda Helicobacter pylori Enfeksiyonunun Duodenit Üzerine Etkisi

Pages
12–16
Publication Date
2022-10-12
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Villous obliteration and duodenal intraepithelial lymphocytosisas histopathological features were seen more commonly in the H. pylori-positive group (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Helicobacter pylori (H. pylori) infection is one of the principal causes of many gastroduodenal diseases, but its role induodenitis development is not exactly known.
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Key Findings & Data:The purpose of this study was to elucidate the role of gastric H. pylori infection onclinical, laboratory, and endoscopical features of duodenitis in patients with dyspepsia.Methods: A total number of 131 patients (77 females and 54 males) were enrolled in the study.
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Conclusion & Impact:Villous obliteration and duodenal intraepithelial lymphocytosisas histopathological features were seen more commonly in the H. pylori-positive group (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Helicobacter pylori (H. pylori) infection is one of the principal causes of many gastroduodenal diseases, but its role induodenitis development is not exactly known. The purpose of this study was to elucidate the role of gastric H. pylori infection onclinical, laboratory, and endoscopical features of duodenitis in patients with dyspepsia.Methods: A total number of 131 patients (77 females and 54 males) were enrolled in the study. The control group was formed fromH. pylori-negative dyspepsia patients (n=60). Clinical, biochemical, and endoscopical evaluations were performed on all subjects.Biopsies were obtained from the gastric antrum, corpus, and duodenal bulb to detect H. pylori and for histopathological assessments.Results: H. pylori infection was positive in 71 patients (54.2%). We detected ulcer-like dyspepsia in 87 patients (66.4%) and dysmotility-likedyspepsia in 44 patients (33.6%). There were no marked differences in biochemical parameters between the groups. On theother hand, there was a marked decrease in ferritin levels in H. pylori-positive group (p=0.001). Endoscopical examination showed thatthe H. pylori-positive group had more frequent erosive duodenitis (p=0.039). Villous obliteration and duodenal intraepithelial lymphocytosisas histopathological features were seen more commonly in the H. pylori-positive group (p

Özet

Amaç: Helicobacter pylori (H. pylori) infeksiyonu, birçok gastroduodenal hastalığın başlıca nedenlerinden biridir, fakat duodenit oluşumundaki rolü tam olarak bilinmemektedir. Bu çalışmanın amacı, dispepsili hastalarda duodenitin klinik, laboratuar ve endoskopik özellikleri üzerine gastrik H. pylori infeksiyonunun rolünü araştırmaktı. Yöntemler: Bu çalışmaya toplamda 131 hasta (77 kadın ve 54 erkek) dahil edildi. Kontrol grubu H. pylori-negatif dispepsi hastalarından oluşturuldu (n=60). Bütün hastalarda klinik, biyokimyasal ve endoskopik değerlendirmeler yapıldı. H. pylori’yi saptamak ve histopatolojik değerlendirmeler için gastrik antrum, korpus ve duodenal bulbusdan biyopsiler alındı. Bulgular: H. pylori infeksiyonu 71 hastada pozitifti (%54,2). Ülser benzeri dispepsiyi 87 hastada (%66,4) ve dismotilite benzeri dispepsiyi 44 hastada tespit ettik (%33,6). Gruplar arasında biyokimyasal parametrelerde anlamlı farklılıklar yoktu. Fakat, H. pylori-pozitif grupta ferritin düzeylerinde anlamlı azalma vardı (p=0,001). Endoskopik muayenede H. pylori-pozitif grupta daha sık erozif duodenit gözlendi (p=0,039). H. pylori-pozitif grupta histopatolojik özellik olarak villus obliterasyonu ve duodenal intraepiteliyal lenfositoz daha çok gözlendi (her iki grup için p

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Cite This Article

KONDUK, B. T., YILDIRIM, A. E., BALKAN, A., BARUTÇU, S., DEMİRYÜREK, Ş., GÜRBÜZ, Y., ER, R. E., ŞENTÜRK, Ö. (2022). Effect of Helicobacter pylori Infection on Duodenitis in Patients with Dyspepsia. European Journal of Therapeutics, Cilt: 24 - Sayı: 1, 12–16. https://ajindex.com/articles/512313

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References (2)

  1. Ford AC, Moayyedi P. Dyspepsia. Curr Opin Gastroenterol 2013; 29: 662-8. [CrossRef] Dore MP, Pes GM, Bassotti G, Usai-Satta P. Dyspepsia: when and how to test for Helicobacter pylori infection. Gastroenterol Res Pract 2016; 2016: 8463614. [CrossRef] Vanheel H, Vicario M, Vanuytsel T, Van Oudenhove L, Martinez C, Keita ÅV, et al. Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia. Gut 2014; 63: 262-71. [CrossRef] Ishigami H, Matsumura T, Kasamatsu S, Hamanaka S, Taida T, Okimoto K, et al. Endoscopy-guided evaluation of duodenal mucosal permeability in functional dyspepsia. Clin Transl Gastroenterol 2017; 8: e83. [CrossRef] Tan HJ, Goh KL. Extragastrointestinal manifestations of Helicobacter pylori infection: facts or myth? A critical review. J Dig Dis 2012; 13: 342-9. [CrossRef] Kamboj AK, Cotter TG, Oxentenko AS. Helicobacter pylori: the past, present, and future in management. Mayo Clin Proc 2017; 92: 599- 604. [CrossRef] Mirbagheri SA, Khajavirad N, Rakhshani N, Ostovaneh MR, Hoseini SM, Hoseini V. Impact of Helicobacter pylori infection and microscopic duodenal histopathological changes on clinical symptoms of patients with functional dyspepsia. Dig Dis Sci 2012; 57: 967-72. [CrossRef] Mirbagheri SS, Mirbagheri SA, Nabavizadeh B, Entezari P, Ostovaneh MR, Hosseini SM, et al. Impact of microscopic duodenitis on symptomatic response to Helicobacter pylori eradication in functional dyspepsia. Dig Dis Sci 2015; 60: 163-7. [CrossRef] Hooi JKY, Lai WY, Ng WK, Suen MMY, Underwood FE, Tanyingoh D, et al. Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis. Gastroenterology 2017; 153: 420-9. [CrossRef] Ozaydin N, Turkyilmaz SA, Cali S. Prevalence and risk factors of Helicobacter pylori in Turkey: a nationally-representative, cross-sectional, screening with the ¹³C-Urea breath test. BMC Public Health 2013; 13: 1215. [CrossRef] Tytgat GN. The Sydney System: endoscopic division. Endoscopic appearances in gastritis/duodenitis. J Gastroenterol Hepatol 1991; 6: 223-34. [CrossRef] Price AB. The Sydney System: histological division. J Gastroenterol Hepatol 1991; 6: 209-22. [CrossRef] Satoh K, Kimura K, Yoshida Y, Kasano T, Kihira K, Taniguchi Y. Relationship between Helicobacter pylori colonization and acute inflammation of the duodenal mucosa. Am J Gastroenterol 1993; 88: 360-3.
  2. Caselli M, Gaudio M, Chiamenti CM, Trevisani L, Sartori S, Saragoni L, et al. Histologic findings and Helicobacter pylori