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Journals / European Journal of Therapeutics / 2020 / Cilt: 26 - Sayı: 2

Role of Serum HMGB1 in Prostate Cancer

Hülya ÇİÇEK
Mehmet SOLAKHAN
Özlem Nuray SEVER
Mustafa YILDIRIM
Necla BENLİER
Zeliha YILDIRIM
Nuri ORHAN
Pages
108–112
Publication Date
2022-10-12
DOI
—
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Significant difference was detected between the three groups (p

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: In our study the diagnostic role of HMGB1 levels measured in serum were investigated in prostatitis and prostate carcinoma diagnosis and in the differential diagnosis of these two diseases.
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Key Findings & Data:Material Method: Patients followed up for histopathologically verified diagnosis of prostate carcinoma and prostatitis in 20142017 at the Urology Clinic were included.
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Conclusion & Impact:Significant difference was detected between the three groups (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: In our study the diagnostic role of HMGB1 levels measured in serum were investigated in prostatitis and prostate carcinoma diagnosis and in the differential diagnosis of these two diseases. Material Method: Patients followed up for histopathologically verified diagnosis of prostate carcinoma and prostatitis in 20142017 at the Urology Clinic were included. HMGB1 measurement in serum was performed with the ELISA method. Results: A total of 78 subjects were included in the study, consisting of 30 (38.5%) prostatitis patients, 25 (32%) prostate carcinoma patients and 23 (29.5%) healthy subjects. HMGB1 was detected as 11.9±2.6 (Range 6.7-18.4) ng/ml in the prostatitis group, 15.1±4.5 (Range 8.4-24.8) ng/ml in the prostate carcinoma patients and as 9.2±3.1 (Range 4.7-18.7) ng/ml in the control group. The difference between the groups were investigated using the Friedman test as HMGB1 did not show normal distribution. Significant difference was detected between the three groups (p

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Cite This Article

ÇİÇEK, H., SOLAKHAN, M., SEVER, Ö. N., YILDIRIM, M., BENLİER, N., YILDIRIM, Z., ORHAN, N. (2022). Role of Serum HMGB1 in Prostate Cancer. European Journal of Therapeutics, Cilt: 26 - Sayı: 2, 108–112. https://ajindex.com/articles/512187

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