AI Summary & Key Takeaways
AI InsightFurther studies are required to investigate the effect of the extract on healthy human cells and to understand signaling pathways.
📌 3 Key Takeaways
Abstract
Objective: Glioblastoma multiforme (GBM) is an aggressive malignant brain tumor common in adults. Owing to the present difficulty in treating GBM, developing alternative methods is of utmost importance. Recently, the efficacy of various plant extractsin cancer treatment have been evaluated. Polygonum cognatum (P. cognatum) known as ‘Madımak’ is used in herbal medicine inTurkey.Methods: In this study, we investigated the cytotoxity of P. cognatum in the treatment of glioblastoma and its contribution to theeffectiveness of doxorubicin (DXR). In the U87 cell line of the P. cognatum and doxorubicin administered at different doses, IC50doses were determined using the 2,3-Bis-(2-Methoxy-4-Nitro-5-Sulfophenyl)-2H-Tetrazolium-5-Carboxanilide (XTT) method andthe effects of combined administration at these doses were examined (respectively 10–125 µg/ml and 0.1–10 µg/ml at 24, 48, and72 h).Results: P. cognatum extract decreased the cell viability of U87 cells in a time and concentration-dependent manner. It also increased the apoptotic effectiveness of DXR in U87 cells.Conclusion: This is the first preliminary study that investigates the treatment of P. cognatum on glioblastoma in vitro. Further studies are required to investigate the effect of the extract on healthy human cells and to understand signaling pathways.