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Journals / European Journal of Rheumatology / 2017 / Cilt: 4 - Sayı: 2

Decrease of serum biomarker of type II Collagen degradation by intra-articular injection of an autologous plasma-rich-platelet in patients with unilateral primary knee osteoarthritis

Rasha Mohamed FAWZY
Nashwa Ismail HASHAAD
Amira Ibrahim MANSOUR
Pages
93–97
Publication Date
2022-10-18
DOI
—
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Results: Significant reduction in S.Coll2-1 concentration in primary knee OA patients; (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This study aimed to evaluate the effect of one dose of intra-articular injection of (PRP) in the knee joint on a specific osteoarthritis (OA) serum biomarker of cartilage degeneration, Collagen 2-1 , over a short period of 3 months.
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Key Findings & Data:They were subdivided according to Kellgren-Lawrence grading scale (KL) into (Group ?): including patients with KL grade =3.
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Conclusion & Impact:Results: Significant reduction in S.Coll2-1 concentration in primary knee OA patients; (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: This study aimed to evaluate the effect of one dose of intra-articular injection of (PRP) in the knee joint on a specific osteoarthritis (OA) serum biomarker of cartilage degeneration, Collagen 2-1 , over a short period of 3 months. The aim extended to clarify the effect of PRP on the functional status of the osteoarthritic knee joint. Material and Methods: Sixty patients with primary unilateral knee OA were enrolled in this study. They were subdivided according to Kellgren-Lawrence grading scale (KL) into (Group ?): including patients with KL grade =3. Patients were asked to complete the Western Ontario and McMaster Universities Arthritis Index (WOMAC) Score. PRP was prepared and injected immediately into the affected knee. Serum Coll2-1 concentration was measured by enzyme-linked immunosorbent assay (ELISA) kit pre and 3 months after PRP injection. Results: Significant reduction in S.Coll2-1 concentration in primary knee OA patients; (p

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Cite This Article

FAWZY, R. M., HASHAAD, N. I., MANSOUR, A. I. (2022). Decrease of serum biomarker of type II Collagen degradation by intra-articular injection of an autologous plasma-rich-platelet in patients with unilateral primary knee osteoarthritis. European Journal of Rheumatology, Cilt: 4 - Sayı: 2, 93–97. https://ajindex.com/articles/511749

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