Low prevalence of obesity in Behçet's disease is associated with high obestatin level

Serum ghrelin levels were similar in the BD and HC groups (p>0.05 for all) although the obestatin level was higher in the BD group compared to the HC group (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Chronic inflammatory diseases are associated with altered body composition.

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Key Findings & Data:Material and Methods: One hundred and forty-three (143) patients with BD and 112 healthy controls (HC) were enrolled.

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Conclusion & Impact:Serum ghrelin levels were similar in the BD and HC groups (p>0.05 for all) although the obestatin level was higher in the BD group compared to the HC group (p

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Objective: Chronic inflammatory diseases are associated with altered body composition. Ghrelin has anti-inflammatory effects, and its level is altered in obesity and inflammatory diseases. The aim of the study was to evaluate the prevalence of obesity and ghrelin and obestatin levels in patients with Behçet's disease (BD). Material and Methods: One hundred and forty-three (143) patients with BD and 112 healthy controls (HC) were enrolled. Participants were subdivided according to the body mass index (BMI) as lean (=30 kg/m2). In addition to the routine evaluations (fasting blood glucose, lipid profile, and kidney and liver function tests), serum acylated-ghrelin (AG), unacylated-ghrelin (UAG), total ghrelin (TG) and obestatin levels were analyzed. Student's t-test and chi-square test were used for statistical analysis. Results: The prevalence of obesity was relatively lower in the BD group than in the HC group (12.6% vs. 20.5%, p=0.089). Serum ghrelin levels were similar in the BD and HC groups (p>0.05 for all) although the obestatin level was higher in the BD group compared to the HC group (p

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Cite This Article

İLHAN, N., KOCA, S. S., IŞIK, A., ÖZGEN, M., DAYANAN, R., DÖNDER, E., AKSOY, K., KARA, M., DEMİR, C. F. (2022). Low prevalence of obesity in Behçet's disease is associated with high obestatin level. European Journal of Rheumatology, Cilt: 4 - Sayı: 2, 113–117. https://ajindex.com/articles/511706

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