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Journals / Eurasian Journal of Veterinary Sciences / 2019 / Cilt: 35 - Sayı: 2

The effect of melatonin on coagulation parameters in rats with cerulein-induced acute pancreatitis

Serulein ile akut pankreatit oluşturulan ratlarda melatoninin koagulasyon parametreleri üzerine etkileri

Deniz ULUIŞIK
Ercan KESKİN
Pages
62–65
Publication Date
2022-10-18
DOI
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In blood samples taken from all animals, platelet,fibrinogen, activated partial thromboplastin time (APTT),prothrombin time (PT), international normalized ratio (INR)levels were determined.Results: Acute pancreatitis caused increment in platelet countand fibrinogen level compared to control group (p

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Objective & Hypothesis:Aim: The aim of this study was to evaluate possible effectsof melatonin on coagulation parameters in rats with ceruleininduced acute pancreatitis.Materials and Methods: For this purpose, 32 adult, male,healthy Wistar Abino rats were used.
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Key Findings & Data:GroupII animals was intraperitoneally administered 50 mg/kg melatoninper rat twice for two hours intervals.
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Conclusion & Impact:In blood samples taken from all animals, platelet,fibrinogen, activated partial thromboplastin time (APTT),prothrombin time (PT), international normalized ratio (INR)levels were determined.Results: Acute pancreatitis caused increment in platelet countand fibrinogen level compared to control group (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: The aim of this study was to evaluate possible effectsof melatonin on coagulation parameters in rats with ceruleininduced acute pancreatitis.Materials and Methods: For this purpose, 32 adult, male,healthy Wistar Abino rats were used. The animals were dividedinto four groups. Group I animals was no applied. GroupII animals was intraperitoneally administered 50 mg/kg melatoninper rat twice for two hours intervals. Animals of groupIII received two intraperitoneal injections of cerulein (50μg/kg and 25 μg/kg bw, respectively) at two hours intervals.Animals of group IV received two intraperitoneal injectionsof cerulein (50 μg/kg and 25 μg/kg bw, respectively) at twohours intervals and the rats received an intraperitoneal injectionof 50 mg/kg melatonin 30 min before each ceruleininjection. In blood samples taken from all animals, platelet,fibrinogen, activated partial thromboplastin time (APTT),prothrombin time (PT), international normalized ratio (INR)levels were determined.Results: Acute pancreatitis caused increment in platelet countand fibrinogen level compared to control group (p

Özet

Amaç: Bu çalışmanın amacı cerulein ile akut pankreatit oluşturulan ratlarda melatoninin koagulasyon parametreleri üzerine olası etkilerini değerlendirmektir. Gereç ve Yöntem: Bu amaçla 32 yetişkin erkek sağlıklı Wistar Abino rat kullanıldı. Hayvanlar dört gruba ayrıldı. Grup 1’deki hayvanlara herhangi bir uygulama yapılmadı. Grup II’deki hayvanlara iki saat aralıkla iki kez 50 mg/kg melatonin intraperitoneal olarak uygulandı. Grup III’deki hayvanlara iki saat aralıkla iki intraperitoneal serulein (sırasıyla, 50 μg/kg ve 25 μg/kg bw) enjeksiyonu yapıldı. Grup IV’deki hayvanlara iki saat aralıkla iki intraperitoneal serulein (sırasıyla, 50 μg/kg ve 25 μg/kg bw) enjeksiyonu yapıldı ve ratlara her bir serulein enjeksiyonundan 30 dk önce intraperitoneal olarak 50 mg/kg melatonin enjeksiyonu yapıldı. Hayvanlardan alınan kan örneklerinde platelet, fibrinojen, APTT, PT, INR düzeyleri belirlendi. Bulgular: Platelet sayısı ve fibrinojen seviyesi akut pankreatite bağlı olarak kontrol grubu ile karşılaştırıldığında arttı (p

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Cite This Article

ULUIŞIK, D., KESKİN, E. (2022). The effect of melatonin on coagulation parameters in rats with cerulein-induced acute pancreatitis. Eurasian Journal of Veterinary Sciences, Cilt: 35 - Sayı: 2, 62–65. https://ajindex.com/articles/509858

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References (16)

  1. Agarwal N, Pitchumoni CS, 1993. Acute pancreatitis: a multisystem disease. Gastroenterologist, 1(2), 115-128.
  2. Baddeley RNB, Skipworth JRA, Pereira SP, 2011. Acute pancreatitis. Medicine, 39(2), 108-115.
  3. Bekyarova G, Tancheva S, Hristova M, 2010. The effects of melatonin on burn-induced inflammatory responses and coagulation disorders in rats. Methods Find Exp Clin Pharmacol, 32(5), 299-303.
  4. Bockman DE, Büchler M, Beger HG, 1986. Ultrastructure of human acute pancreatitis. Int J Pancreatol, 1(2), 141-153.
  5. Bouchard BA, Tracy PB, 2001. Platelets, leukocytes, and coagulation. Curr Opin Hematol, 8(5), 263-269.
  6. Carrillo-Vico A, Guerrero JM, Lardone PJ, Reiter RJ, 2005. A review of the multiple actions of melatonin on the immune system. Endocrine, 27(2), 189-200.
  7. Claustrat B, Brun J, Chazot G, 2005. The basic physiology and pathophysiology of melatonin. Sleep Med Rev, 9(1), 11-24.
  8. Dahm A, Osterud B, Hjeltnes N, Sandset PM, Iversen PO, 2006. Opposite circadian rhythms in melatonin and tissue factor pathway inhibitor type 1: does daylight affect coagulation?. J Thromb Haemost, 4(8), 1840-1842.
  9. Dhainaut JF, Marin N, Mignon A, Vinsonneau C, 2001. Hepatic response to sepsis: Interaction between coagulation and inflammatory processes. Crit Care Med, 29(7), 42-47. Esmon CT, 1999. Possible involvement of cytokines in diffuse intravascular coagulation and thrombosis. Baillieres Best Pract Res Clin Haematol, 12(3), 343-359.
  10. Esmon CT, Taylor FB, Snow TR, 1991. Inflammation and coagulation: linked processes potentially regulated through a common pathway mediated by protein C. Thromb Haemost, 66(1), 160-165.
  11. Förstermann U, Münzel T, 2006. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation, 113(13), 1708-1714.
  12. Goldacre MJ, Roberts SE, 2004. Hospital admission for acute pancreatitis in an English population, 1963-98: database study of incidence and mortality. BMJ, 328(7454), 1466- 1469. Hackert T, Pfeil D, Hartwig W, Fritz S, Schneider L, Gebhard MM, Büchler MW, Werner J, 2007. Platelet Function in Acute Experimental Pancreatitis. J Gastrointest Surg, 11(4), 439-444.
  13. Kakafika A, Papadopoulos V, Mimidis K, Mikhailidis DP, 2007.
  14. Coagulation, Platelets, and Acute Pancreatitis. Pancreas, 34(1), 15-20.
  15. Lasson A, Ohlsson K, 1986. Consumptive coagulopathy, fibrinolysis and protease-antiprotease interactions during acute human pancreatitis. Thromb Res, 41(2), 167-183.
  16. Levi M, Van Der Poll T, Büller HR, 2004. Bidirectional relation between inflamma