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Journals / Eurasian Journal of Veterinary Sciences / 2021 / Cilt: 37 - Sayı: 2

Comparison of steroid and platelet-rich plasma (PRP) applications in the treatment of collagenase induced tendinopathy in rabbit

Tavşanların tendon yangılarının sağaltımında steroid ve trombositten zengin plazma (TZP) uygulamalarının karşılaştırmalı araştırılması

Nuriza ZAMIRBEKOVA
Nuri YAVRU
Pages
82–92
Publication Date
2022-10-18
DOI
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Results: Statistically significant differences were detected between the treatment groups and the 0.9% saline injected group (p0.05) without tenocyte nuclei (p

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Objective & Hypothesis:Aim: The aim of this study was to evaluate histopathologically the therapeutic effects of platelet-rich plasma (PRP) and MPA (methylprednisolone acetate) injections in rabbits achill tendinopathies induced by collagenase (Collagenase Type I) Materials and Methods: Achilles tendinopathy was formed with intrathendinous injections of type I collagenase into the proximal and distal regions of the right and left achilles tendons of 23 rabbits.
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Key Findings & Data:A 0,9% saline solution was also injected into the proximal parts of all achilles tendons.
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Conclusion & Impact:Results: Statistically significant differences were detected between the treatment groups and the 0.9% saline injected group (p0.05) without tenocyte nuclei (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: The aim of this study was to evaluate histopathologically the therapeutic effects of platelet-rich plasma (PRP) and MPA (methylprednisolone acetate) injections in rabbits achill tendinopathies induced by collagenase (Collagenase Type I) Materials and Methods: Achilles tendinopathy was formed with intrathendinous injections of type I collagenase into the proximal and distal regions of the right and left achilles tendons of 23 rabbits. PRP was injected distal to the right Achilles tendons and MPA to the distal of the left Achilles tendons. A 0,9% saline solution was also injected into the proximal parts of all achilles tendons. Rabbits were euthanized 3, 6, and 8 weeks after the therapeutic injections. The degree of histopathological degeneration of the tendons was made according to the Modified Movin scoring. Results: Statistically significant differences were detected between the treatment groups and the 0.9% saline injected group (p0.05) without tenocyte nuclei (p

Özet

Amaç: Bu çalışmada, tavşanlarda kollajenaz (Kollajenaz Tip I) ile oluşturulmuş aşil tendinopatilerinde trombositten zengin plazma (PRP) ve MPA (metilprednizolon asetat) enjeksiyonlarının terapötik etkilerini histopatolojik olarak değerlendirmeyi amaçlamıştır. Gereç ve Yöntem: Aşil tendinopatisi, 23 tavşanın sağ ve sol aşil tendonlarının proksimal ve distal bölgelerine intratendinöz tip I kollajenaz enjeksiyonu ile oluşturuldu. Kolajenaz enjeksiyonundan bir hafta sonra, sağ aşil tendonlarının distaline PRP ve sol aşil tendonlarının distaline MPA enjekte edildi. Tüm aşil tendonlarının proksimal kısımlarına %0,9 serum fizyolojik enjekte edildi. Tavşanlar, terapötik enjeksiyonlardan 3, 6 ve 8 hafta sonunda ötenazi edildi. Tendonların histolojik dejenerasyon derecesi Modifiye Movin skorlamasına göre yapıldı. Bulgular: Tedavi grupları ile % 0,9’luk serum fizyolojik enjekte edilen grup arasında incelenen tüm dönemlerde istatistiksel açıdan önemli farklılıklar tespit (p

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Cite This Article

ZAMIRBEKOVA, N., YAVRU, N. (2022). Comparison of steroid and platelet-rich plasma (PRP) applications in the treatment of collagenase induced tendinopathy in rabbit. Eurasian Journal of Veterinary Sciences, Cilt: 37 - Sayı: 2, 82–92. https://ajindex.com/articles/509762

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