We present the case of a 54-year-old woman with deep vein thromboembolism andpulmonary embolism as the first signs of cancer, who was subsequently diagnosed with disseminatedadenocarcinoma, most likely originated from the pancreatico-biliary system.
📌 3 Key Takeaways
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Objective & Hypothesis:Venous thromboembolism is one of the most common complications of cancer, which also contributesto mortality in cancer patients.
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Key Findings & Data:Venous thromboembolism can be observed as the first manifestationof occult cancer.
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Conclusion & Impact:We present the case of a 54-year-old woman with deep vein thromboembolism andpulmonary embolism as the first signs of cancer, who was subsequently diagnosed with disseminatedadenocarcinoma, most likely originated from the pancreatico-biliary system.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Venous thromboembolism is one of the most common complications of cancer, which also contributesto mortality in cancer patients. Venous thromboembolism can be observed as the first manifestationof occult cancer. We present the case of a 54-year-old woman with deep vein thromboembolism andpulmonary embolism as the first signs of cancer, who was subsequently diagnosed with disseminatedadenocarcinoma, most likely originated from the pancreatico-biliary system.
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Cite This Article
Aygencel, G., Kara, I., Türkoğlu, M., Yıldırım, F., Çınar, H. (2022). Submassive pulmonary thromboembolism as a first sign of occult adenocarcinoma. Eurasian Journal of Pulmonology, Cilt: 20 - Sayı: 2, 107–110. https://ajindex.com/articles/509682
Hidalgo M. Pancreatic cancer. N Engl J Med 2010;362:1605‑17
Khorana AA, Fine RL. Pancreatic cancer and thromboembolic disease. Lancet Oncol 2004;5:655‑63
Ryan DP, Hong TS, Bardeesy N. Pancreatic adenocarcinoma. N Engl J Med 2014;371:1039‑49
Nakchbandi IA, Löhr JM. Coagulation, anticoagulation and pancreatic carcinoma. Nat Clin Pract Gastroenterol Hepatol 2008;5:445‑55
Kasthuri RS, Taubman MB, Mackman N. Role of tissue factor in cancer. J Clin Oncol 2009;27:4834‑8
Mandalà M, Reni M, Cascinu S, Barni S, Floriani I, Cereda S, et al. Venous thromboembolism predicts poor prognosis in irresectable pancreatic cancer patients. Ann Oncol 2007;18:1660‑5
Li D, Pise MN, Overman MJ, Liu C, Tang H, Vadhan‑Raj S, et al. ABO non‑O type as a risk factor for thrombosis in patients with pancreatic cancer. Cancer Med 2015;4:1651‑8
Thapa SD, Hadid H, Usman M. Pulmonary embolism and stroke as the initial manifestation of advanced metastatic pancreatic adenocarcinoma. J Gastrointest Cancer 2015;46:182‑4
Vlachostergios PJ, Oikonomou KG, Cheema MA, Apergis G. Saddle pulmonary embolism as the initial manifestation of pancreatic cancer. Intern Med 2015;54:687‑8
Majumder S, Thom T, Dasanu CA. Catastrophic arteriovenous thromboembolism as initial manifestation of pancreatic cancer. J Oncol Pract 2012;13:231‑4
Ben‑Aharon I, Stemmer SM, Leibovici L, Shpilberg O, Sulkes A, Gafter‑Gvili A, et al. Low molecular weight heparin (LMWH) for primary thrombo‑prophylaxis in patients with solid malignancies—systematic review and meta‑analysis. Acta Oncol 2014;53:1230‑7
Larsen AC, Frøkjaer JB, Iyer VW, Fisker RV, Sall M, Yilmaz MK, et al. Venous thrombosis in pancreaticobiliary tract cancer: Outcome and prognostic factors. J Thromb Haemost 2015;13:555‑62.