Journals / Eurasian Journal of Medicine / 2009 / Cilt: 41 - Sayı: 3

Bir böbrek transplantasyonu hastasında takrolimustan kaynaklanan progresif nörolojik bozukluk: Olgu sunumu

A case report of a renal transplant patient with progressive neurological disorder due to tacrolimus

Pages
200–201
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this article we presented our case of a renal allograft receiver with nausea, dizziness and fatigue complaints.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Neurological complications of tacrolimus are usually mild (tremors, paresthesia, myalgia), however, serious complications that result in encephalopathy, convulsions and coma can be seen.
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Key Findings & Data:Serious complications are more frequently reported following liver transplants and lungs transplants than renal transplants and are typically seen when tacrolimus concentrations exceed the 15 ng/L therapeutic limit.
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Conclusion & Impact:In this article we presented our case of a renal allograft receiver with nausea, dizziness and fatigue complaints.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Neurological complications of tacrolimus are usually mild (tremors, paresthesia, myalgia), however, serious complications that result in encephalopathy, convulsions and coma can be seen. Serious complications are more frequently reported following liver transplants and lungs transplants than renal transplants and are typically seen when tacrolimus concentrations exceed the 15 ng/L therapeutic limit. In this article we presented our case of a renal allograft receiver with nausea, dizziness and fatigue complaints.

Özet

Takrolimusun nörolojik komplikasyonları genellikle hafiftir (tremor, parestezi ve miyalji), ancak ensefalopati, konvülziyonlar ve koma ile seyreden ciddi komplikasyonlarda görülebilir. Ciddi komplikasyonlar çoğunlukla böbrek transplantasyonundan ziyade karaciğer ve akciğer transplantasyonu sonrası bildirilmiştir ve tipik olarak takrolimus konsantrasyonu 15 ng/l'lik terapötik sınırın üzerine çıktığı zaman görülür. Bu yazıda bulantı, baş dönmesi, halsizlik şikayeti görülen bir böbrek allogreft alıcısı olgumuzu sunduk.

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Cite This Article

SAĞIROĞLU, T., MEYDAN, B. (2022). Bir böbrek transplantasyonu hastasında takrolimustan kaynaklanan progresif nörolojik bozukluk: Olgu sunumu. Eurasian Journal of Medicine, Cilt: 41 - Sayı: 3, 200–201. https://ajindex.com/articles/509400

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References (4)

  1. Chegounchi M, Hana MG, Neild GH. Progressive neurological disease induced by tacrolimus in a renal transplant recipient: Case presentation. BMC Nephrology 2006; 7: 7
  2. Fruhauf NR, Koeppen DS, Saner FH, et al. Late onset of tacrolimus-related posterior leukoencephalopathy after donor liver transplantion. Liver Transpl 2005; 9: 983-5
  3. Bechstein WO. Neurotoxicity of calcineurin inhibitors: impact and clinical management. Transpl Int 2000; 13: 313-26
  4. Kemper MJ, Guiseppina S, Laube GF, Miozzari M, Neuhaus TJ. Neuropsychologic sideeffects of tacrolimus in pediatric renal transplantation. Clin Transplant 2003; 17: 130-4.