SavedAdd your journal

Journals / Eurasian Journal of Medicine / 2009 / Cilt: 41 - Sayı: 3

Spinal anestezide ropivakaine farklı dozlarda klonidin ilavesinin etkileri

The effects of adding various doses of clonidine to ropivacaine in spinal anesthesia

Tamer SAĞIROĞLU
Gönül SAĞIROĞLU
Burhan MEYDAN
Pages
149–153
Publication Date
2022-10-18
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In group I, time to two segment regression and time to sensory block to S2 was shorter when compared to the other groups (P

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: In this study, we compared the clinical effects of combined doses of ropivacaine and clonidine.
📊
Key Findings & Data:Materials and Methods: Seventy-five patients between ages 18 and 75, in ASA I-III groups who were to undergo elective lower extremity surgery, were included in the study with informed consent.
💡
Conclusion & Impact:In group I, time to two segment regression and time to sensory block to S2 was shorter when compared to the other groups (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: In this study, we compared the clinical effects of combined doses of ropivacaine and clonidine. Materials and Methods: Seventy-five patients between ages 18 and 75, in ASA I-III groups who were to undergo elective lower extremity surgery, were included in the study with informed consent. Subjects were randomly assigned to 3 groups. Group I: % 1 ropivacaine 12 mg, group II: % 1 ropivacaine 12 mg + clonidine 15 μg, group III: % 1 ropivacaine 12 mg + clonidine 30 μg. Mean arterial pressure, breathing, heart rate and peripheral oxygen saturation, total amount of ephedrine and atropine used, sensory and motor block levels, level of sedation, pain level and complications were monitored.Results: The mean arterial pressure recorded in group III decreased significantly at 75, 105 and 120 min compared to groups I and II. In group I, time to two segment regression and time to sensory block to S2 was shorter when compared to the other groups (P

Özet

Amaç: Çalışmamızda intratekal olarak uygulanan ropivakaine iki farklı dozda klonidin ilavesinin klinik etkilerini karşılaştırmayı amaçladık. Gereç ve Yöntem: Bilgilendirilmiş onam alınmış ASA I-III grubunda, 18-75 yaşlarında, elektif alt ekstremite ameliyatı planlanan 75 hasta çalışmaya alındı. Olgular rasgele örnekleme tekniğiyle 3 gruba ayrıldı. Grup I: % 1 ropivakain 12 mg, grup II % 1 ropivakain 12 mg + klonidin 15 μg, grup III % 1 ropivakain 12 mg + klonidin 30 μg. Ortalama arter basıncı, solunum sayısı, kalp atım hızı, periferik oksijen satürasyonu, kullanılan toplam efedrin ve atropin dozları, sensoriyal ve motor blok seviyesi, sedasyonun derecesi, ağrı seviyesi ve komplikasyonlar takip edildi.Bulgular: Ortalama arter basıncı, grup III’te grup I ve II ile karşılaştırıldığında 75, 105, 120. dk’larda anlamlı düşüş gösterdi. Grup I’de sensoriyal bloğun 2 segment gerileme süresi ve sensoriyal bloğun S2 düzeyine inme süresi diğer iki gruptan anlamlı derecede kısaydı (p

🔖

Cite This Article

SAĞIROĞLU, T., SAĞIROĞLU, G., MEYDAN, B. (2022). Spinal anestezide ropivakaine farklı dozlarda klonidin ilavesinin etkileri. Eurasian Journal of Medicine, Cilt: 41 - Sayı: 3, 149–153. https://ajindex.com/articles/509392

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Rauck RL, Eisenach JC, Jackson K, et al. Epidural clonidine for refractory reflex sympathetic distrophy. Anesthesiology 1991; 75: 657-8
  2. Aydınlı I. Ropivakain. Anestezi Dergisi 1997; 5: 143-6
  3. Gautier P, De Kock M, Van Steenberge A, et al. İntrathecal ropivacaine for ambulatory surgery: a comparison between intrathecal bupivacaine and intrathecal ropivacaine for knee arthroscopy.Anesthesiology 1999; 91: 1239-45
  4. Mc Namee DA, Parks L, Mc Clelland AM, et al. İntrathecal ropivacaine for total hip arthroplasty: double-blind comparative study with isobaric 7.5 % mg ml-1 and 10 mg ml-1 solutions. Br J Anaesth 2001; 87: 743-7
  5. Malinovsky JM, Charles F, Baudrimont M, et al. İntrathecal ropivacaine in rabbits: Pharmacodynamic and neurotoxicologic study. Anesthesiology 2002; 97: 429-35
  6. Sklitsi F, Drimeri I, Kritharidou G, et al. Comparison of two different concentrations of ropivacaine for spinal anaesthesia in orthopaedic surgery. Eur J Anaesthesiol 2000; 17: 67-72
  7. Griffin RP, Reynolds F. Extradural anaesthesia for caesarean section: a double-blind comparison of 0.5 % ropivacaine with 0.5 % bupivacaine. Br J Anaesth 1995; 74: 512-6
  8. Eisenach J, Detweiler D, Hood D. Hemodynamic and analgesic actions of epidurally administered clonidine. Anesthesiology 1993; 78: 277-87
  9. De Kock M, Gautier P, Fanard L, et al. İntrathecal ropivacaine and clonidine for ambulatory knee arthroscopy. Anesthesiology 2001; 94: 574-8
  10. Hayashi Y, Maze M. Alpha2- adrenoceptor agonist and anaesthesia. Br J Anaesth 1993; 71: 108-18
  11. Van Kleef JW, Veering B, Burm A. Spinal anesthesia with ropivacaine: a double-blind study on the efficacy and safety of 0.5 % and 0.75 % solutions in patients undergoing minor lower limb surgery. Anesth Analg 1994; 78: 1125-30
  12. Çınar Ö, Oba S, Ekşioğlu B. Bupivakain’e eklenen klonidin ve fentanil’in epidural kullanımının anestezik ve analjezik etkilerinin karşılaştırılması. Türk Anest Rean Cem Mec 2001; 29: 271-6
  13. Klimscha W, Chiari A, Krafft P, et al. Hemodynamic and analgesic effects of clonidine added repetetively to continuous epidural and spinal blocks. Anesth Analg 1995; 80: 322-7
  14. Racle P, Benkhadra A, Poy JY, et al. Prolongation of isobaric bupivacaine spinal anesthesia with epinephrine and clonidine for hip surgery in the elderly. Anesth Analg 1987; 66: 442-6
  15. Gentili G, Bonnet F. Spinal clonidine produces less urinary retention than spinal morphine. Br J Anaesth 1996; 76: 872-3
  16. Carabine UA, Milligan K