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Journals / Eurasian Journal of Medicine / 2009 / Cilt: 41 - Sayı: 1

Türkler'de koroner arter hastalığı ve kolesterol ester transfer proteinin genetik varyasyonu arasındaki ilişki

The relationship between genetic variations of the cholesteryl ester transfer protein gene and coronary artery disease in turkish subjects

Hasan DOĞAN
Hüseyin ŞENOCAK
Şule KARAKELLOĞLU
İbrahim PİRİM
Yekta GÜRLERTOP
Serdar SEVİMLİ
Fuat GÜNDOĞDU
Şakir ARSLAN
Hülya AKSOY
Pages
32–38
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Patients with the B1B1 genotype had lower high-density lipoprotein-cholesterol (HDL-C) and higher triglyceride (TG) levels than patients with the B2B2 genotype (p

📌 3 Key Takeaways

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Objective & Hypothesis:Although the relationship between cholesteryl ester transfer protein (CETP) and cholesterol metabolism has been characterized in recent years, the effect of CETP genetic variants associated with coronary artery disease (CAD) is still unclear.
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Key Findings & Data:We conducted a case-control study that included 194 unrelated subjects who underwent coronary angiography for suspected ischemic heart disease.
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Conclusion & Impact:Patients with the B1B1 genotype had lower high-density lipoprotein-cholesterol (HDL-C) and higher triglyceride (TG) levels than patients with the B2B2 genotype (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective. Although the relationship between cholesteryl ester transfer protein (CETP) and cholesterol metabolism has been characterized in recent years, the effect of CETP genetic variants associated with coronary artery disease (CAD) is still unclear. Therefore, we investigated the association between CETP gene polymorphism and levels of lipid in patients with CAD. Materials and Methods. We conducted a case-control study that included 194 unrelated subjects who underwent coronary angiography for suspected ischemic heart disease. This group was divided into 96 patients with angiographically documented CAD and 98 subjects (individuals matched for age and gender) without angiographically documented CAD (CAD-free subjects), all of whom were studied to examine the genotypic distribution of the CETP gene polymorphism in CAD. Genotyping was performed via polymerase chain reaction.Results. Of the 96 patients with CAD, 38 (40%) were B1B1, 42 (44%) B1B2 and 16 (16%) B2B2, compared with the control subjects, of which 35 (36%) were B1B1, 44 (45%) B1B2 and 19 (19%) B2B2. There were no significant differences between patients with CAD and control subjects in the distribution of the CETP gene polymorphism. Patients with the B1B1 genotype had lower high-density lipoprotein-cholesterol (HDL-C) and higher triglyceride (TG) levels than patients with the B2B2 genotype (p

Özet

Amaç. Son yıllarda kolesterol metabolizması ile kolesterol ester transfer proteini (KETP) arasındaki ilişki bilinmesine rağmen, KETP'nin genetik varyantlarının koroner arter hastalığı (KAH) ile ilişkisi hala açık değildir. Bu nedenle çalışmamızda, KAH'lı hastalarda lipid düzeyleri ile KETP gen polimorfizmi arasındaki ilişki araştırmayı amaçladık. Gereç ve Yöntem. İskemik kalp hastalığı şüphesiyle koroner anjiyografi ile incelenen 194 hasta üzerinde olgu-kontrol çalışması yapıldı. Anjiyografi ile 96 kişinin KAH ve 98 kişininde (cinsiyet ve yaş eşleşmiş) KAH olmadığı belgelenerek, KAH'da KETP gen polimorfizminin genotipik dağılımı çalışıldı. Genotip, polimeraz zincir reaksiyonuyla belirlendi.Bulgular. Koroner arter hastalığı olan 96 hastanın 38'i (40%) B1B1, 42'si (44%) B1B2 ve 16'sı (16%) B2B2 olup kontrol bireyleri ile kıyaslandığında 35'i (36%) B1B1, 44'ü (45%) B1B2 ve 19'u (19%) B2B2 idi. KETP gen polimorfizminin genotipik dağılımı için kontrol bireyleri ile KAH'lı hastalar arasında önemli farklar yoktu. B1B1 genotipine sahip hastalar B2B2 genotipine sahip hastalara oranla daha yüksek trigliserid ve daha düşük yüksek-dansiteli lipoprotein kolesterol (HDL-K) düzeyine sahipti (p

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Cite This Article

DOĞAN, H., ŞENOCAK, H., KARAKELLOĞLU, Ş., PİRİM, İ., GÜRLERTOP, Y., SEVİMLİ, S., GÜNDOĞDU, F., ARSLAN, Ş., AKSOY, H. (2022). Türkler'de koroner arter hastalığı ve kolesterol ester transfer proteinin genetik varyasyonu arasındaki ilişki. Eurasian Journal of Medicine, Cilt: 41 - Sayı: 1, 32–38. https://ajindex.com/articles/509356

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