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Journals / Eurasian Journal of Medicine / 2020 / Cilt: 52 - Sayı: 1

Do Resveratrol and Dehydroepiandrosterone Increase Diminished Ovarian Reserve?

Bilgin KAYGISIZ
Kevser EROL
Fikriye Yasemin ÖZATİK
Semra YİĞİTASLAN
Orhan ÖZATİK
Pages
6–11
Publication Date
2022-10-18
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

Follicle stimulating hormone (FSH), estradiol (E2) and anti-mullerian hormone (AMH) valueswere measured.Results: In control group, VCD-induced apoptosis in follicles increased the TUNEL-positive cell counts(p

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Objective & Hypothesis:Objective: In this study, the aim is to observe changes induced by dehydroepiandrosterone (DHEA) andresveratrol (RES) in diminished ovarian follicles that was induced by 4-vinylcyclohexenediepoxide (VCD).Materials and Methods: Twenty four Wistar albino female rats were divided into 3 groups: control, DHEAand RES.
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Key Findings & Data:Unilateral oophorectomy was performed in control group to remove the right ovary of 4 rats andthe left ovary of 4 rats.
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Conclusion & Impact:Follicle stimulating hormone (FSH), estradiol (E2) and anti-mullerian hormone (AMH) valueswere measured.Results: In control group, VCD-induced apoptosis in follicles increased the TUNEL-positive cell counts(p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: In this study, the aim is to observe changes induced by dehydroepiandrosterone (DHEA) andresveratrol (RES) in diminished ovarian follicles that was induced by 4-vinylcyclohexenediepoxide (VCD).Materials and Methods: Twenty four Wistar albino female rats were divided into 3 groups: control, DHEAand RES. Unilateral oophorectomy was performed in control group to remove the right ovary of 4 rats andthe left ovary of 4 rats. After administration of 160 mg/kg VCD, remaining ovaries were removed. Following the same VCD treatment, in DHEA and RES groups, 60 mg/kg DHEA and 20 mg/kg RES were givenfor 45 days respectively and residual ovaries were removed. Hematoxylin-eosin and TUNEL staining wereperformed. Follicle stimulating hormone (FSH), estradiol (E2) and anti-mullerian hormone (AMH) valueswere measured.Results: In control group, VCD-induced apoptosis in follicles increased the TUNEL-positive cell counts(p

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Cite This Article

KAYGISIZ, B., EROL, K., ÖZATİK, F. Y., YİĞİTASLAN, S., ÖZATİK, O. (2022). Do Resveratrol and Dehydroepiandrosterone Increase Diminished Ovarian Reserve?. Eurasian Journal of Medicine, Cilt: 52 - Sayı: 1, 6–11. https://ajindex.com/articles/509354

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References (1)

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