Journals / Eurasian Journal of Medicine / 2014 / Cilt: 46 - Sayı: 3

Relation of Preoperative Thrombocytosis between Tumor Stage and Grade in Patients with Endometrial Cancer

Endometriyum Kanserlerinde Preoperatif Trombosit Sayısının Tümör Grade ve Evre ile İlişkisi

Pages
164–168
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: We found that preoperative platelet count was not correlated with the stage or grade of endometrial cancer.

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Objective & Hypothesis:Objective: We aimed to evaluate the predictive value of preoperative thrombocytosis for postoperative tumor stage and tumor grade in patients with endometrial cancer.Materials and Methods: This was a retrospective study carried out in our gynecologic oncology department between January 2000 and December 2011.
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Key Findings & Data:We reviewed the medical charts of 190 patients diagnosed with endometrial carcinoma and underwent complete staging procedure.
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Conclusion & Impact:Conclusion: We found that preoperative platelet count was not correlated with the stage or grade of endometrial cancer.
🔬Design:Review & Systematic Survey
📍Scope:2000 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: We aimed to evaluate the predictive value of preoperative thrombocytosis for postoperative tumor stage and tumor grade in patients with endometrial cancer.Materials and Methods: This was a retrospective study carried out in our gynecologic oncology department between January 2000 and December 2011. We reviewed the medical charts of 190 patients diagnosed with endometrial carcinoma and underwent complete staging procedure. The clinicopathologic characteristics of the patients such as; age, gravidity, parity, menopausal status, body mass index, co-morbidities (diabetes, hypertension etc.), stage, grade, histological subtype, depth of myometrial invasion, peritoneal washing cytology and preoperative platelet count were recorded. Endometrioid adenocarcinomas were graded according to the FIGO classification. Blood samples for the measurement of platelet count were obtained 3 days prior to the surgery. Thrombocytosis was defined as a platelet count of 300×109/L. P values less than 0.05 derived from two-tailed tests were considered statistically significant.Results: The mean age of the study population was 55.4 years. The mean gravidity was 3.8 and the mean parity was 3.32 . 108 (56,8%) patients were with body mass index of >30 kg/m². The mean platelet count among women was 288, 6±90.7×109/L (range 105-772×109/L). The majority of the patients were with early stage diseases during the surgeries. 170 (89.5%) of the patients had stage I to II disease, and 20 (10.5%) of them had stage III to IV disease. There were no statistical significance between thrombocytosis and age, gravidity, parity, BMI, cancer grade and stage, histological subtype of the tumor, depth of invasion, cervical involvement, intrauterine tumor volume and peritoneal washing cytology. Conclusion: We found that preoperative platelet count was not correlated with the stage or grade of endometrial cancer.

Özet

Amaç: Endometrium kanseri olan hastalarda preoperatif trombositozun postoperatif tümör evre ve derecesini tahmin etmedeki değerini değerlendirmeyi amaçladık.Gereç ve Yöntem: Bu çalışma ocak 2000 ve aralık 2011 yılları arasında jinekoloji onkoloji birimimizde retrospektif bir çalışma olarak yapılmıştır. Tam bir cerrahi evreleme yapılan endometrial karsinoma tanılı 190 hastanın medikal kayıtları incelendi. Hastaların yaş, gravida, parite, menapozal durum, vücut kitle indeksi, eşlik eden morbiditeleri (diyabet, hipertansiyon vb.), evre, derece, histolojik alt tip, miyometriyal invazyon derinliği, periton yıkama sitolojisi ve preoperatif trombosit sayısı gibi klinik ve patolojik özellikleri kayıt edildi. Endometrioid adenokarsinomalar FİGO klasifikasyonuna göre derecelendirildi. Trombosit sayısı cerrahi işlemden 3 gün önce elde edildi. 300×109/L'in üzerindeki trombosit değerleri trombositozis olarak değerlendirildi. 0,05'in altındaki p değerleri istatistiksel olarak anlamlı olarak kabul edildi.Bulgular: Çalışma grubundaki hastaların ortalama yaşı 55,4 idi. Ortalama gravide 3.8 ve ortalama parite 3,32 idi. 108 (%56,8) hastanın vücut kitle indeksi >30 kg/m² idi. Ortalama platelet sayısı 288, 6±90,7×109/L (dağılım 105772×109/L) idi. Cerrahiler sırasında hastaların çoğunu erken evre hastalığı olanlar oluşturuyordu. Hastaların 170 (%89,5)'i evre 1-2 iken, 20 (%10,5)'si evre 3-4 idi. Trombositoz ile yaş, gravida, parite, BMI, kanser derecesi, evresi, histolojik alt tipi, invazyon derinliği, servikal tutulum, intrauterin tümör hacmi ve peritoneal yıkama arasında istatistiksel anlamlılık saptanmadı. Sonuç: Çalışmamızda endometrium kanserinin evre ya da derecesi ile preoperatif trombosiztoz arasında ilişki olmadığını saptadık.

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Cite This Article

DAGDEVİREN, H., GURASLAN, H., TEKİRDAG, A. I., KALOGLU, S., KAYA, C. (2022). Relation of Preoperative Thrombocytosis between Tumor Stage and Grade in Patients with Endometrial Cancer. Eurasian Journal of Medicine, Cilt: 46 - Sayı: 3, 164–168. https://ajindex.com/articles/509165

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