Journals / Eurasian Journal of Medicine / 2014 / Cilt: 46 - Sayı: 1

Karaciğer rezeksiyonu sonrası oluşan hepatit C virüsü ile bağlantılı hepatosellüler karsinom rekürrensi prediktörleri: Retrospektif bir çalışma

Predictors of recurrence in hepatitis C virus related hepatocellular carcinoma after hepatic resection: A retrospective cohort study

Pages
36–41
Publication Date
2022-10-18
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Predictors of HCC recurrence were assessedby bivariate correlation tests, univariate analysis using the chi-squareand t-test and binary logistic regression analysis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Egypt is one of the hot spots in the international mapof Hepatocellular carcinoma (HCC), which is where hepatitis C virus(HCV) infection is the major risk factor in development of HCC (80%).Due to low organ donation rates and lack of deceased liver transplantation, hepatic resection is the main line of treatment for HCCpatients with sufficient liver reserve.
📊
Key Findings & Data:This is the first study to come from a country where chronicHCV hepatitis is endemic.Materials and Methods: This is a retrospective cohort study of 208cases of HCC in hepatitis C virus positive patients with cirrhotic livers who underwent first-time liver resection, in GastroenterologySurgical Centre, Mansoura University, Egypt during the period fromJanuary 2002 to December 2011.
💡
Conclusion & Impact:Predictors of HCC recurrence were assessedby bivariate correlation tests, univariate analysis using the chi-squareand t-test and binary logistic regression analysis.
🔬Design:Research Article
📍Scope:2002 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Egypt is one of the hot spots in the international mapof Hepatocellular carcinoma (HCC), which is where hepatitis C virus(HCV) infection is the major risk factor in development of HCC (80%).Due to low organ donation rates and lack of deceased liver transplantation, hepatic resection is the main line of treatment for HCCpatients with sufficient liver reserve. We introduce our experiencewith patients who had HCV related HCC who underwent hepatic resection to determine various predictors of tumour recurrence in thisgroup. This is the first study to come from a country where chronicHCV hepatitis is endemic.Materials and Methods: This is a retrospective cohort study of 208cases of HCC in hepatitis C virus positive patients with cirrhotic livers who underwent first-time liver resection, in GastroenterologySurgical Centre, Mansoura University, Egypt during the period fromJanuary 2002 to December 2011. Shapiro-Wilk test was used to as-sess normality of data. Predictors of HCC recurrence were assessedby bivariate correlation tests, univariate analysis using the chi-squareand t-test and binary logistic regression analysis. A P value

Özet

Amaç: Mısır; hepatit C virüsü (HCV) enfeksiyonunun Hepatocellular karsinomun (HCC) görülmesinde önemli (% 80) bir risk faktörü olduğu, uluslararası HCC haritasındaki sıcak noktalardan biridir. Organ bağışı oranlarının düşük olması ve kadavradan karaciğer nakli eksikliği sebebiyle, karaciğer rezeksiyonu, yeterli karaciğer rezervi olan HCC hastalarının tedavisinde ana yöntemdir. Bu grupta HCV’ye bağlıHCC’si olan hastalarda tümör nüksünün çeşitli faktörlerini araştırmak için karaciğer rezeksiyonu deneyimimizi aktarmak amacındayız. Bu, kronik HCV hepatitinin endemik olduğu bir ülkeden gelen ilk çalışmadır. Gereç ve Yöntem: Bu, Ocak 2002-Aralık 2011 süresince Mısır’ın Mansoura Üniversitesi, Gastroenterolojik Cerrahi Merkezinde ilk kez karaciğer rezeksiyonu yapılan sirotik karaciğerli HCC, hepatit C virüsü pozitif hastalarda 208 vakanın retrospektif kohort çalışmasıdır. Verilerin normalliğini değerlendirmek için Shapiro-Wilk testi kullanılmıştır. HCC nüks prediktörleri ikili korelasyon testleri, tek değişkenli ki- kareve t - testi analizi ve lojistik regresyon analizi kullanılarak değerlendirilmiştir. p

🔖

Cite This Article

WAHAB, M. A., SHEHTA, A., HAMED, H., NAKEEB, A. E., SALAH, T. (2022). Karaciğer rezeksiyonu sonrası oluşan hepatit C virüsü ile bağlantılı hepatosellüler karsinom rekürrensi prediktörleri: Retrospektif bir çalışma. Eurasian Journal of Medicine, Cilt: 46 - Sayı: 1, 36–41. https://ajindex.com/articles/509144

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Li T, Fan J, Qin LX, et al. Risk factors, prognosis, and management of early and late intrahepatic recurrence after resection of primary clear cell carcinoma of the liver. Ann Surg Oncol 2011
  2. [CrossRef] 2. Jelic S, Sotiropoulos GC
  3. ESMO Guidelines Working Group. Hepatocellular carcinoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 2010
  4. [CrossRef] 3. Abdel-wahab M, El-Husseiny T, El-Hanafy E, et al. Prognostic factors affecting survival and recurrence after hepatic resection for hepatocellular carcinoma in cirrhotic liver. Langenbecks Arch Surg 2010
  5. [CrossRef] 4. Ho CM, Lee PH, Shau WY, et al. Survival in patients with recurrent hepatocellular carcinoma after primary hepatectomy: comparative effectiveness of treatment modalities. Surgery 2012
  6. [CrossRef] 5. Committee of the International Hepato-Pancreato-Biliary Association. IHPBA Brisbane Terminology of Liver Anatomy and Resections. England
  7. Kim SH, Choi SB, Lee JG, et al. Prognostic factors and 10-year survival in patients with hepatocellular carcinoma after curative hepatectomy. J Gastrointest Surg 2011
  8. [CrossRef] 7. Kobayashi A, Kawasaki S, Miyagawa S, et al. Results of 404 hepatic resections including 80 repeat hepatectomies for hepatocellular carcinoma. Hepato-Gastroenterolo 2006
  9. Huang ZY, Liang B, Xiong M, et al. Long-term outcomes of repeat hepatic resection in patients with recurrent hepatocellular carcinoma and analysis of recurrent types and their prognosis: a single-center experience in China. Ann Surg Oncol 2012
  10. [CrossRef] 9. Huang YH, Wu JC, Chen CH, et al. Comparison of recurrence after hepatic resection in patients with hepatitis B vs. hepatitis C-related small hepatocellular carcinoma in hepatitis B virus endemic area. Liver Int 2005
  11. [CrossRef] 10. Kao WY, Su CW, Chau GY, et al. A comparison of prognosis between patients with hepatitis B and C virus-related hepatocellular carcinoma undergoing resection surgery. World J Surg 2011
  12. [CrossRef] 11. Takenaka K, Yamamoto K, Taketomi A, et al. A comparison of the surgical results in patients with hepatitis B versus hepatitis C-related hepatocellular carcinoma. Hepatology 1995
  13. [CrossRef] 12. Qin LX, Tang ZY. The prognostic significance of clinical and pathological features in hepatocellular carcinoma. World J Gastroenterol 2002
  14. Ou DP, Yang LY, Huang GW,