NF-κB, SUMO and Ubiquitination Relationship

It is involved in many biologicalpathways and leads the marked proteins to destruction by directing them to the proteosomesystem.In this review NF-κB, SUSMO and ubiquitin proteins and their relationship to each other will bediscussed.

📌 3 Key Takeaways

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Objective & Hypothesis:NF-κB is a transcription factor that regulates the expression of genes by directly binding to DNA.It’s involved in immune system, cell survival, cell proliferation, learning and memory processes.The SUMO protein, which is involved in post-translational modification, regulates the function ofexogenous proteins and there are four homologs in mammals.Another protein involved in post-translational modification is ubiquitin.

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Key Findings & Data:NF-κB is a transcription factor that regulates the expression of genes by directly binding to DNA.It’s involved in immune system, cell survival, cell proliferation, learning and memory processes.The SUMO protein, which is involved in post-translational modification, regulates the function ofexogenous proteins and there are four homologs in mammals.Another protein involved in post-translational modification is ubiquitin.

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Conclusion & Impact:It is involved in many biologicalpathways and leads the marked proteins to destruction by directing them to the proteosomesystem.In this review NF-κB, SUSMO and ubiquitin proteins and their relationship to each other will bediscussed.

🔬Design:Review & Systematic Survey

📍Scope:Comprehensive Sample

⚙️Variables:NF-κB · SUMO · Sumoylasyon

Abstract

NF-κB is a transcription factor that regulates the expression of genes by directly binding to DNA.It’s involved in immune system, cell survival, cell proliferation, learning and memory processes.The SUMO protein, which is involved in post-translational modification, regulates the function ofexogenous proteins and there are four homologs in mammals.Another protein involved in post-translational modification is ubiquitin. It is involved in many biologicalpathways and leads the marked proteins to destruction by directing them to the proteosomesystem.In this review NF-κB, SUSMO and ubiquitin proteins and their relationship to each other will bediscussed.

Özet

NF-κB, DNA’ya doğrudan bağlanarak genlerin ekspresyonunu düzenleyen bir transkripsiyon faktörüdür.İmmünitede, hücre sağkalımında, hücre çoğalmasında, öğrenme ve bellek süreçlerinde görevlidir.Post-translasyonel modifikasyonda görevli olan SUMO proteini eksprese edilen proteinlerin fonksiyonlarınıdüzenler ve memelilerde dört adet homoloğu bulunmaktadır.Bir diğer posttranslasyonel modifikasyonda görevli olan protein ise ubikitindir. Birçok biyolojik yolaktayer alır ve işaretlediği proteinleri proteozom sistemine yönlendirerek yıkımını sağlar.Bu derlemede NF-κB, SUMO ve ubikitin proteinlerinden ve birbirleriyle olan ilişkilerinden bahsedilecektir.

Keywords

NF-κB SUMO Sumoylasyon Ubikitin Ubikitinasyon Ubikitin-proteozom sistemi Sumolation Ubiquitin Ubiquitination Ubiquitin-Proteosome system

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Cite This Article

ŞEN, M., AY, U., AKBAYIR, E., ŞENYER, S., TÜZÜN, E., KÜÇÜKALİ, C. İ. (2017). NF-κB, SUMO and Ubiquitination Relationship. Experimed, Cilt: 7 - Sayı: 13, 35–46. https://ajindex.com/articles/50877

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