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Journals / Eurasian Journal of Family Medicine / 2018 / Cilt: 7 - Sayı: 1

Positive Correlation Between Platelet Parameters and Genetic Markers of Thrombophilia Panel in Recurrent Pregnancy Loss

Tekrarlayan Gebelik Kaybı Öyküsü Olan Hastalarda Genetik Trombofili Paneli ve Platelet Parametreleri Arasındaki Pozitif Korelasyon

Taha BAHSİ
Abdulkadir KAYA
Ahmet Cevdet CEYLAN
Haktan Bağış ERDEM
Zeynep Sever ERDEM
İbrahim ŞAHİN
Abdulgani TATAR
Pages
19–28
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: Factor II g.20210G>A (p=0.035), Factor V Leiden mutations (p=0.027) and PAI-1 (4G/5G) (p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Recurrent pregnancy loss (RPL) defined as 3 or more miscarriages before 20 weeks of gestation by the World Health Organization, and is a common complication during pregnancy, especially for early gestation and affects about 1–5 % of pregnant.
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Key Findings & Data:In this study, we analyzed mean platelet volume (MPV), platelet count (PLT) values, Factor II g.20210G>A, Factor V Leiden, MTHFR (C677T, A1298C), PAI-1, β-fibrinogen, Factor XIIIA (V34L) and glycoprotein IIIa (L33P) polymorphisms of patients who have RPL history and searched the relationship between genetic thrombophilia markers and platelet parameters in RPL.
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Conclusion & Impact:Results: Factor II g.20210G>A (p=0.035), Factor V Leiden mutations (p=0.027) and PAI-1 (4G/5G) (p
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Recurrent pregnancy loss (RPL) defined as 3 or more miscarriages before 20 weeks of gestation by the World Health Organization, and is a common complication during pregnancy, especially for early gestation and affects about 1–5 % of pregnant. In this study, we analyzed mean platelet volume (MPV), platelet count (PLT) values, Factor II g.20210G>A, Factor V Leiden, MTHFR (C677T, A1298C), PAI-1, β-fibrinogen, Factor XIIIA (V34L) and glycoprotein IIIa (L33P) polymorphisms of patients who have RPL history and searched the relationship between genetic thrombophilia markers and platelet parameters in RPL. Methods: A retrospective, clinical trial was performed by reviewing the recurrent pregnancy loss history of 229 patients, and 200 controls. The results of the genetic thrombophilia panel were used to classify the study and control group into low, intermediate and high risk for thrombophilia groups. Results: Factor II g.20210G>A (p=0.035), Factor V Leiden mutations (p=0.027) and PAI-1 (4G/5G) (p

Özet

Amaç: Tekrarlayan gebelik kaybı, Dünya Sağlık Örgütü tarafından gebeliğin 20. haftasından önce gerçekleşmiş 3 veya daha fazla gebelik kaybı olarak tanımlanmakta olup, gebelerin %1-5’ini etkileyen yaygın bir komplikasyondur. Çalışmamızda, tekrarlayan gebelik kaybı öyküsü olan hastaların, ortalama platelet hacmi, platelet sayısı ve genetik trombofili paneli (Factor II g.20210G>A, Factor V Leiden, MTHFR (C677T, A1298C), PAI-1, β-fibrinogen, Factor XIIIA (V34L), Glycoprotein IIIa (L33P)) analiz edilerek, tekrarlayan gebelik kayıplarında platelet parametreleri ve genetik parametreler arasındaki ilişki araştırılmıştır. Yöntem: Çalışma için, tekrarlayan gebelik kaybı öyküsü olan 229 hasta ve 200 kontrol üzerinde retrospektif klinik çalışma planlanmıştır. Genetik trombofili panelinin sonuçlarına göre hasta grubu yüksek, orta ve düşük riskli olmak üzere 3 gruba ayrılmıştır. Bulgular: Factor II g.20210G>A (p=0,035) ve Factor V Leiden (p=0,027) mutasyonları, MTHFR (C677T, A1298C) polimorfizmleri (p

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Cite This Article

BAHSİ, T., KAYA, A., CEYLAN, A. C., ERDEM, H. B., ERDEM, Z. S., ŞAHİN, İ., TATAR, A. (2022). Positive Correlation Between Platelet Parameters and Genetic Markers of Thrombophilia Panel in Recurrent Pregnancy Loss. Eurasian Journal of Family Medicine, Cilt: 7 - Sayı: 1, 19–28. https://ajindex.com/articles/508386

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