SavedAdd your journal

Journals / Eurasian Journal of Emergency Medicine / 2014 / Cilt: 13 - Sayı: 4

Experience of Treatments of Amanita Phalloides-induced Fulminant Liver Failure with Molecular Adsorbent Recirculating System and Therapeutic Plasma Exchange

Ying ZHANG
Chunting WANG
Jicheng ZHANG
Zhiyong PENG
Xueqiang XUEQİANG
Pengfei BİAN
Wenjuan MA
Chengyong QİN
Pages
181–186
Publication Date
2022-10-11
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

A single session of TPE produced greater improvements in ALT (-58.6% vs -12.5%), AST (-44.2% vs -26.9%), total bilirubin (-44.4% vs -12.5%), and PT (-51.2% vs -4.89%) compared to a single session of MARS (all p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: To evaluate the effects of molecular adsorbent recirculating system (MARS) and therapeutic plasma exchange (TPE) on patients with amanita phalloides-induced fulminant liver failure.
📊
Key Findings & Data:Results: The survival rate for the nine patients in this study was 66.7%.
💡
Conclusion & Impact:A single session of TPE produced greater improvements in ALT (-58.6% vs -12.5%), AST (-44.2% vs -26.9%), total bilirubin (-44.4% vs -12.5%), and PT (-51.2% vs -4.89%) compared to a single session of MARS (all p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: To evaluate the effects of molecular adsorbent recirculating system (MARS) and therapeutic plasma exchange (TPE) on patients with amanita phalloides-induced fulminant liver failure. Material and Methods: We retrospectively analyzed nine cases of amanita phalloides poisoning where MARS and/or TPE was applied. Results: The survival rate for the nine patients in this study was 66.7%. Patients who received both MARS and TPE therapies experienced higher survival rates than those who received MARS or TPE alone (100% vs 0%, 50%). A single session of TPE produced greater improvements in ALT (-58.6% vs -12.5%), AST (-44.2% vs -26.9%), total bilirubin (-44.4% vs -12.5%), and PT (-51.2% vs -4.89%) compared to a single session of MARS (all p

🔖

Cite This Article

ZHANG, Y., WANG, C., ZHANG, J., PENG, Z., XUEQİANG, X., BİAN, P., MA, W., QİN, C. (2022). Experience of Treatments of Amanita Phalloides-induced Fulminant Liver Failure with Molecular Adsorbent Recirculating System and Therapeutic Plasma Exchange. Eurasian Journal of Emergency Medicine, Cilt: 13 - Sayı: 4, 181–186. https://ajindex.com/articles/508245

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Durukan P, Yildiz M, Cevik Y, Ikizceli I, Kavalci C, Celebi S. Poisoning from wild mushrooms in Eastern Anatolia region: analysis of 5 years. Hum Exp Toxicol 2007
  2. [CrossRef] 2. Bronstein AC, Spyker DA, Cantilena LR, Green JL, Rumack BH, Giffin SL. 2009 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 27th Annual Report. Clin Toxicol 2010
  3. [CrossRef] 3. Enjalbert F, Rapior S, Nouguier-Soulé J, Guillon S, Amouroux N, Cabot C. Treatment of amatoxin poisoning 20-Year retrospective analysis. J of Toxicol 2002
  4. Broussard CN, Aggarwal A, Lacey SR, Post AB, Gramlich T, Henderson JM, et al. Mushroom poisoning-from diarrhea to liver transplantation. Am J Gastroenterol 2001
  5. Karlson-Stiber C, Persson H. Cytotoxic fungi-an overview. Toxicon 2003
  6. [CrossRef] 6. Chaiear K, Limpaiboon R, Meechai C, Poovorawan Y. Fatal mushroom poisoning caused by Amanita virosa in Thailand. Southeast Asian J Trop Med Public Health 1999
  7. Iliev Y, Andonova S, Akabaliev V. Our experience in the treatment of acute Amanita phalloides poisoning. Folia Med (Plovdiv) 1999
  8. Ganzert M, Felgenhauer N, Zilker T. Indication of liver transplantation following amatoxin intoxication. J Hepatol 2005
  9. [CrossRef] 9. Tan HK. Molecular adsorbent recirculating system (MARS). Ann Acad Med Singapore 2004
  10. Trabulus S, Altiparmak M.R. Clinical features and outcome of patients with amatoxin- containing mushroom poisoning. Clin Toxicol 2011
  11. [CrossRef] 11. Sorodocn L, Lionte C, Sorodoc V, Petris O, Jaba I.Is MARS system enough for A.phalloides-induced liver failure treatment? Hum Exp Toxicol 2010
  12. [CrossRef] 12. Jander S, Bischoff J. Treatment of Amanita phalloides poisoning: I. Retrospective evaluation of plasmapheresis in 21 patients. Therap Apher 2000
  13. [CrossRef] 13. Schutt C R, Ronco C, Rosner M H. The Role of Therapeutic Plasma Exchange in Poisonings and Intoxications. Semin Dial 2012
  14. [CrossRef] 14. Parsons-Smith B G, Summerskill W H, Dawson A M, Sherlock S. The electroencephalograph in liver disease. Lancet 1957
  15. [CrossRef] 15. Himmelmann A, Mang G, Schnorf-Huber S. Lethal ingestion of stored Amanita phalloides mushrooms. Swiss Med Wkly 2001
  16. Aji DY, Calişkan S, Nayir A, Mat A, Can B, Yaşar Z, et al: Haemoperfusion in Amanita phalloides poisoning. J Trop Ped