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Journals / Eurasian Journal of Emergency Medicine / 2015 / Cilt: 14 - Sayı: 4

Hypothermia in Cardiac Arrest: A Meta-Analysis and Evidence-Based Appraisal of the Current Data

Cenker EKEN
Pages
164–166
Publication Date
2022-10-11
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This evidence-based article aimed to appraise the current literature and perform a meta-analysis

📌 3 Key Takeaways

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Objective & Hypothesis:Cooling the human body, particularly the brain, has been of concern for a long time.
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Key Findings & Data:The resuscitation guideline by the American Heart Association that was released in 2010 declared therapeutic hypothermia, defined as maintaining the body temperature between 32°C and 34°C for 12-24 h, as a Class I intervention in cardiac arrest patients secondary to ventricular fibrillation.
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Conclusion & Impact:This evidence-based article aimed to appraise the current literature and perform a meta-analysis
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Domain Parameters

Abstract

Cooling the human body, particularly the brain, has been of concern for a long time. The resuscitation guideline by the American Heart Association that was released in 2010 declared therapeutic hypothermia, defined as maintaining the body temperature between 32°C and 34°C for 12-24 h, as a Class I intervention in cardiac arrest patients secondary to ventricular fibrillation. However, the targeted temperature management (TTM) trial released after the aforementioned guideline has contrary results compared with the previous one. This evidence-based article aimed to appraise the current literature and perform a meta-analysis

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Cite This Article

EKEN, C. (2022). Hypothermia in Cardiac Arrest: A Meta-Analysis and Evidence-Based Appraisal of the Current Data. Eurasian Journal of Emergency Medicine, Cilt: 14 - Sayı: 4, 164–166. https://ajindex.com/articles/508197

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References (8)

  1. Wu TC, Grotta JC. Hypothermia for acute ischaemic stroke. Lancet Neurol
  2. [CrossRef] Peberdy MA, Callaway CW, Neumar RW, Geocadin RG, Zimmerman JL, Donnino M, et al. Post-cardiac Arrest Care: 2010 American Heart Asso- ciation Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2010
  3. S768-S86. [CrossRef] Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, et al. Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia. N Engl J Med 2002
  4. [CrossRef] Holzer M, Cerchiari E, Martenz P, Roine R, Sterz F, Eisenburger F, et al.
  5. Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypo- thermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002
  6. [CrossRef] Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, et al. Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med 2013
  7. [CrossRef] % CI 521-1.099 577-0.954 Nielsen et al. Total (fixed effects) /375 /555 /377 /549 025 912 798-1.043 Total (random effects) /555 /549 855 673 to 1.087 Study Bernard et al. (3) Holzer et al. (4) Intervention /43 /136 Controls /34 /137 696 740 % CI 488-0.992 588-0.932 Nielsen et al. (5) Total (fixed effects) /469 /648 /464 /635 014 924 833-1.026 Total (random effects) /648 /635 831 639-1.079 Figure 2. Meta-analysis displaying the pooled effect of hypothermia on death and poor neurological outcome Eurasian J Emerg Med 2015
  8. 6 Hypothermia in Cardiac Arrest