Journals / Erciyes Tıp Dergisi / 2004 / Cilt: 26 - Sayı: 1

Yaşa bağlı makula dejenerasyonunda serum MDA ve AOPP düzeyleri

Serum MDA and AOPP levels in age related macular degeneration

Pages
7–11
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Increased MDA levels could indicate that lipid peroxidation might be implicated in the pathophysiology of AMD.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: Our aim was to reveal advanced oxidation protein products (AOPP), novel marker ofoxidative stress as markers of protein oxidation, as well as malondialdehyde (MDA) levels as a marker of lipid peroxidation in age-related macular degeneration (AMD).
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Key Findings & Data:Material and Methods: Serum MDA and AOPP levels . were measured in 27 patients with AMD and 10 healthy subjects.
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Conclusion & Impact:Conclusion: Increased MDA levels could indicate that lipid peroxidation might be implicated in the pathophysiology of AMD.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: Our aim was to reveal advanced oxidation protein products (AOPP), novel marker ofoxidative stress as markers of protein oxidation, as well as malondialdehyde (MDA) levels as a marker of lipid peroxidation in age-related macular degeneration (AMD). Material and Methods: Serum MDA and AOPP levels . were measured in 27 patients with AMD and 10 healthy subjects. Serum MDA levels and oxidative stress biomarker, AOPP levels, were measured spectrophotometrically. Results: When compared with healthy controls, MDA evels were found to be significantly higher in AMD patients (p0.05). Conclusion: Increased MDA levels could indicate that lipid peroxidation might be implicated in the pathophysiology of AMD.

Özet

Amaç: Bu çalışmada yaşa bağlı makula dejenerasyonu (AMD) hastalarında protein oksidasyonunun yeni bir belirleyicisi olan ileri okside protein ürünleri (AOPP) düzeyi ile lipid peroksidasyon göstergesi olan malondialdehit (MDA) düzeylerinin ölçülmesi amaçlandı.Materyal metod: Serum MDA ve AOPP düzeyleri 27 AMD'li hasta ve 10 sağlıklı bireyde ölçüldü. Serum MDA ve AOPP düzeylerinin ölçümünde spektrofotometrik yöntem kullanıldı. Bulgular: MDA düzeyleri, hasta grubunda anlamlı derecede yüksek bulundu (p0.05). Sonuç: AMD hastalarında tespit edilen yüksek MDA düzeyleri, bu hastalığın patogenezinde lipid peroksidasyonunun rol oynayabileceğini göstermektedir.

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Cite This Article

ÖNER, A., KARAKÜÇÜK, S., MİRZA, G. E., KOÇER, D., BAŞKOL, G. (2022). Yaşa bağlı makula dejenerasyonunda serum MDA ve AOPP düzeyleri. Erciyes Tıp Dergisi, Cilt: 26 - Sayı: 1, 7–11. https://ajindex.com/articles/503194

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