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Journals / Erciyes Tıp Dergisi / 2009 / Cilt: 31 - Sayı: 2

Thrombophilia mutation frequencies in recurrent pregnancy losses

Tekrarlayan gebelik kayıplarında trombofili mutasyon sıklıkları

Belgin ATAÇ
Hulusi Bülent ZEYNELOĞLU
Zerrin YILMAZ
Feride İffet ŞAHİN
Pages
104–109
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results were analyzed statistically by Chi-square, Fisher's exact test and for the low genotype frequencies by G test.Results: We did not detect a statistically significant relationship between genotypes of the three investigated gene regions and recurrent abortus and control groups (p>0.05).Conclusion: According to the results of the current study, there is not a statistically significant relationship between the patient and control groups and genotypes.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: In the current study we aimed to detect Factor V Leiden (FVL), prothrombin G20210A (Prt) ve methylenetetrahydrofolate reductase (MTHFR) C677T mutation frequencies in women with or without recurrent pregnancy losses.Material and Methods: A total of 205 women with two or more pregnancy losses and 100 women without a history of abortuses were included in the study.
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Key Findings & Data:Results were analyzed statistically by Chi-square, Fisher's exact test and for the low genotype frequencies by G test.Results: We did not detect a statistically significant relationship between genotypes of the three investigated gene regions and recurrent abortus and control groups (p>0.05).Conclusion: According to the results of the current study, there is not a statistically significant relationship between the patient and control groups and genotypes.
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Conclusion & Impact:Our results support recent reports.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: In the current study we aimed to detect Factor V Leiden (FVL), prothrombin G20210A (Prt) ve methylenetetrahydrofolate reductase (MTHFR) C677T mutation frequencies in women with or without recurrent pregnancy losses.Material and Methods: A total of 205 women with two or more pregnancy losses and 100 women without a history of abortuses were included in the study. Thrombophilia mutations were detected by PR-RFLP analyses. Results were analyzed statistically by Chi-square, Fisher's exact test and for the low genotype frequencies by G test.Results: We did not detect a statistically significant relationship between genotypes of the three investigated gene regions and recurrent abortus and control groups (p>0.05).Conclusion: According to the results of the current study, there is not a statistically significant relationship between the patient and control groups and genotypes. Our results support recent reports.

Özet

Amaç: Tekrarlayan gebelik kaybı (TGK)öyküsü olan ve olmayan kadınlarda, Faktör V Leiden (FVL), protrombin G20210A (Prt) ve metilentetrahidrofolat redüktaz (MTHFR) C677T' yi içeren üç trombofili mutasyonunun sıklığının belirlenmesi ve karşılaştırılması amaçlanmıştır.Gereç ve Yöntemler: Çalışma kapsamına iki veya daha fazla kez tekrarlayan gebelik kaybı öyküsü olan 205 kadın ve kontrol grubu olarak gebelik kaybı öyküsü olmayan 100 kadın birey alındı. Trombofili mutasyonları PCR-RFLP analizi ile belirlenerek genotipler ile TGK ve kontrol grubu arasındaki ilişki ki-kare testi, Fisher's exact test ve genotip frekanslarının düşük olduğu gen bölgesi için G testi ile analiz edildi.Bulgular: İstatistiksel değerlendirme sonucunda incelenen üç gen bölgesi için genotipler ile tekrarlayan gebelik kaybı olan hastalar ve kontrol grubu arasında anlamlı ilişki saptanmadı (p>0,05).Sonuç: Son yıllarda yayınlanmış çalışmalara benzer şekilde bizim sonuçlarımıza göre de hasta ve kontrol grubu ile genotipler arasında anlamlı bir ilişki saptanmamıştır.

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Cite This Article

ATAÇ, B., ZEYNELOĞLU, H. B., YILMAZ, Z., ŞAHİN, F. İ. (2022). Thrombophilia mutation frequencies in recurrent pregnancy losses. Erciyes Tıp Dergisi, Cilt: 31 - Sayı: 2, 104–109. https://ajindex.com/articles/503185

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