Journals / Erciyes Tıp Dergisi / 2009 / Cilt: 31 - Sayı: 3

Term bebeklerde kemik matürasyonunun belirlenmesinde kord kanı insülin-benzeri büyüme faktörü (IGF-1) düzeylerinin rolü

The role of umbilical cord blood insulin like growth factor-1 levels in the assessment of bone maturation in term neonates

Pages
213–217
Publication Date
2022-10-17
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Although IGF-1 level had significantly positive correlations with body surface area, birth weight, midarm circumference did not correlate with gestational age, birth length, head circumference, ponderal index and skinfold thickness.Conclusion: Cord blood IGF-1 level is useful for assessing the bone maturation in neonates, because a changes in IGF-1 correlates with the change in epiphyseal area.

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Objective & Hypothesis:Purpose: In this study, we aimed to investigate the relation of anthropometric data and knee epiphyseal area with cord blood Insulin Like Growth Factor-1 (IGF-1) levels at birth in term neonates.Material and Method: Twenty-six term neonates were recruited.
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Key Findings & Data:The knee epiphyseal area was calculated by the addition of [width x height x 3.1415/4] of the distal femoral epiphysis and proximal tibia epiphysis.Results: Mean concentrations of IGF-1 levels of cord blood and the knee epiphyseal area were 45.2 ± 36.8 ng/ml and 29.0 ± 18.4 mm2 in term neonates, respectively.
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Conclusion & Impact:Although IGF-1 level had significantly positive correlations with body surface area, birth weight, midarm circumference did not correlate with gestational age, birth length, head circumference, ponderal index and skinfold thickness.Conclusion: Cord blood IGF-1 level is useful for assessing the bone maturation in neonates, because a changes in IGF-1 correlates with the change in epiphyseal area.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: In this study, we aimed to investigate the relation of anthropometric data and knee epiphyseal area with cord blood Insulin Like Growth Factor-1 (IGF-1) levels at birth in term neonates.Material and Method: Twenty-six term neonates were recruited. Anthropometric measures and the knee epiphyseal area were recorded and umbilical cord blood samples were collected at birth. The knee epiphyseal area was calculated by the addition of [width x height x 3.1415/4] of the distal femoral epiphysis and proximal tibia epiphysis.Results: Mean concentrations of IGF-1 levels of cord blood and the knee epiphyseal area were 45.2 ± 36.8 ng/ml and 29.0 ± 18.4 mm2 in term neonates, respectively. IGF-1 levels correlated significantly with knee epiphyseal area (r: 0.45, p: 0.018). In a multiple regression model, IGF-1 emerged as independent correlates for mean knee epiphyseal area in term neonates with the total variance being 18 %. Although IGF-1 level had significantly positive correlations with body surface area, birth weight, midarm circumference did not correlate with gestational age, birth length, head circumference, ponderal index and skinfold thickness.Conclusion: Cord blood IGF-1 level is useful for assessing the bone maturation in neonates, because a changes in IGF-1 correlates with the change in epiphyseal area.

Özet

Amaç: Bu çalışmada term bebeklerde antropometrik ölçümler ve diz epifiz yüzeyi ile kord kanı IGF-1 düzeyi arasındaki ilişkiler araştırıldı.Gereç ve Yöntem: Çalışmaya 26 term bebek alındı. Doğumda kord kanı IGF-1 düzeyi ölçüldü ve antropometrik ölçümler alınırken, diz grafisinde epifiz yüzeyi en boy ve pi/4 çarpımıyla hesaplandı.Bulgular: Kord kanı IGF-1 düzeyi ortalaması 45,2 ± 36,8 ng/ml ve epifiz yüzeyi 29,0 ± 18,4 mm2 bulundu. Kord dayanarak kord kanı IGF-1 düzeyinin kemik ve vücut büyümesi üzerine etkili olduğu sonucuna varıldı. Ayrıca kord serum IGF-1 düzeyi ile vücut yüzeyi, doğum ağırlığı, sol orta kol çevresi arasında pozitif korrelasyon bulunurken, gebelik haftası, doğum boyu , başçevresi ve triseps cild kıvrım kalınlığı ile korelasyon saptanmadı.Sonuç: Elde edilen verilere dayanarak, kord kanı IGF-1 düzeyinin kemik ve vücut büyümesi üzerine etkili faktörlerden biri olduğu sonucuna varıldı.

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Cite This Article

HATİPOĞLU, N., ATABEK, M. E., KURTOĞLU, S., PİRGON, Ö. (2022). Term bebeklerde kemik matürasyonunun belirlenmesinde kord kanı insülin-benzeri büyüme faktörü (IGF-1) düzeylerinin rolü. Erciyes Tıp Dergisi, Cilt: 31 - Sayı: 3, 213–217. https://ajindex.com/articles/503183

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