Journals / Erciyes Tıp Dergisi / 2011 / Cilt: 33 - Sayı: 3

Paneth cell like changes in the epididymis

Epididimisde paneth hücre benzeri değişiklikler

Pages
239–242
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this report I have discussed the mechanism of paneth cell like changes, structure of secretory granules and whether these changes are true metaplasia.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Paneth cells that occur regularly in the bottom of cyrpts of Lieberkühn in the small intestine are pyramidal-shape cells that contain largely eosinophilic granules.
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Key Findings & Data:A 57 years old patient was operated for testicular mass.
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Conclusion & Impact:In this report I have discussed the mechanism of paneth cell like changes, structure of secretory granules and whether these changes are true metaplasia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Paneth cells that occur regularly in the bottom of cyrpts of Lieberkühn in the small intestine are pyramidal-shape cells that contain largely eosinophilic granules. These cells are rarely present in extragastrointestinal sites. A 57 years old patient was operated for testicular mass. Pathologic diagnosis of the testicular mass was seminom. In the non-tumoral epididymis tissue widely distributed paneth cell like change was seen during microscopic examination. In this report I have discussed the mechanism of paneth cell like changes, structure of secretory granules and whether these changes are true metaplasia.

Özet

Paneth hücreleri incebarsakta Lieberkühn kriptlerinin bazalinde yerleşik iri sekretuar granülleri olan piramidal şekilli hücrelerdir. Gastrointestinal sistem dışı organlarda nadir görülür. Testiste kitle nedeni ile opere edilen 57 yaşındaki hastada patolojik değerlendirmede seminom tespit edildi. Nontümöral epididim dokusunda yaygın Paneth hücre benzeri değişiklikler görüldü. Bu çalışmada epididimde nadir görülen Paneth hücre benzeri değişikliklerin oluş mekanizması, sekretuar granüllerin yapısı, gerçek bir metaplazi olup olmadığı tartışıldı.

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Cite This Article

HALTAŞ, H. (2022). Paneth cell like changes in the epididymis. Erciyes Tıp Dergisi, Cilt: 33 - Sayı: 3, 239–242. https://ajindex.com/articles/503178

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References (10)

  1. Shah VI, Ro JY, Amin MB, Mullick S, Nazeer T, Ayala AG. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg Pathol 1998;22(8):990-996
  2. Lugo M, Putong PB. Metaplasia. An overview. Arch Pathol Lab Med 1984; 108:185-189
  3. Niemiec TR, Mercer LJ, Stephens JK, Hajj SN. Unusual urethral diverticulum lined by colonic epithelium with Paneth cell metaplasia. Am J Obstet Gynecol 1989;160(1):186-188
  4. Frydman CP, Bleiweiss IJ, Unger PD, Gordon RE, Brazenas NV. Paneth cell-like metaplasia of the prostate gland. Arch Pathol Lab Med 1992;116(3):274-276
  5. Nevalainen TJ, Shah VI, de Peralta-Venturina M, Amin MB. Absence of group II phospholipase A2, a Paneth cell marker, from the epididymis. APMIS 2001;109(4): 295-298
  6. Weaver MG, Abdul-Karim FW, Srigley J, Bostwick DG, Ro JY, Ayala AG. Paneth cell-like change of the prostate gland. A histological, immunohistochemical, and electron microscopic study. Am J Surg Pathol 1992;16(1):62-68
  7. Ariza A, López D, Castellà EM, Muñoz C, Zújar MJ, Mate JL. Expression of CD15 in normal and metaplastic Paneth cells of the digestive tract. J Clin Pathol. 1996;49(6):474-477
  8. Schned AR, Memoli VA. Coarse granular cytoplasmic change of the epididymis. An immunohistochemical and ultrastructural study. J Urol Pathol 1994;2:213-222
  9. Rubio CA, Nesi G. A simple method to demonstrate normal and metaplastic Paneth cells in tissue sections. In Vivo 2003;17(1):67-71
  10. Nistal M, Marino-Enriquez A, De Miguel MP. Granular changes (Paneth cell-like) in epididymal epithelial cells are lysosomal in nature and are not markers of obstruction. Histopathology 2007;50(7): 944 – 947.