Journals / Erciyes Tıp Dergisi / 2006 / Cilt: 28 - Sayı: 2

The N2 wave of event-related potentials reflects the novelty of the eliciting stimuli

Olaya ilişkin potansiyellerinin N2 dalgası, uyaranların yeniliğini yansıtmaktadır

Pages
49–56
Publication Date
2022-10-17
DOI
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However, the N2 potential generated by the novel targets did not show any significant difference to the novel non-targets, and was significantly higher in amplitude compared with those of the ERPs to typical targets.Conclusion: The greater N2 wave observed both in responses to novel targets and novel non-targets is the real index of the novelty of inducing stimuli.

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Objective & Hypothesis:Purpose: The typical novelty paradigm in cognitive electrophysiology is an experimental design, in which the effects of novel stimuli on brain electrical activity are measured using unexpected and ever-changing novel non-target stimuli interspersed in the set of standards and targets of the classical oddball paradigm.
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Key Findings & Data:The typical event-related potential (ERP) component obtained during the novelty paradigm is a N2-P3a complex occurring in response to novel non-targets.
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Conclusion & Impact:However, the N2 potential generated by the novel targets did not show any significant difference to the novel non-targets, and was significantly higher in amplitude compared with those of the ERPs to typical targets.Conclusion: The greater N2 wave observed both in responses to novel targets and novel non-targets is the real index of the novelty of inducing stimuli.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: The typical novelty paradigm in cognitive electrophysiology is an experimental design, in which the effects of novel stimuli on brain electrical activity are measured using unexpected and ever-changing novel non-target stimuli interspersed in the set of standards and targets of the classical oddball paradigm. The typical event-related potential (ERP) component obtained during the novelty paradigm is a N2-P3a complex occurring in response to novel non-targets. The aim of present study is to determine more specific ERP component for detection of novelty.Material and Methods: We recorded visual ERP from 9 electrode sites (international 10/20 system) on ten healthy volunteer subjects participated in our study. We applied a new experimental paradigm, in which novel stimuli were placed as task-relevant targets instead of being distracting non-targets, and we compared the ERPs elicited with the novel targets in this paradigm both with those elicited by novel non-targets in the novelty paradigm and by constant targets in the standard oddball paradigm.Results: Obtained data show that the P3 potentials were affected both by the novelty and the targetness of the eliciting stimuli. However, the N2 potential generated by the novel targets did not show any significant difference to the novel non-targets, and was significantly higher in amplitude compared with those of the ERPs to typical targets.Conclusion: The greater N2 wave observed both in responses to novel targets and novel non-targets is the real index of the novelty of inducing stimuli.

Özet

Amaç: Bilişsel elektrofizyolojideki yenilik (novelty) paradigması, klasik bir oddball paradigmasındaki standart ve hedef uyaranlar arasına beklenmedik ve sürekli değişen tipteki hedef olmayan yeni (novel) uyaranların serpiştirilmesiyle, yeni uyaranların beyin elektriksel aktivitesi üzerindeki etkilerinin incelenmesini sağlayan bir deney tasarımıdır. Yenilik paradigması sırasında elde edilen tipik olaya ilişkin potansiyel (OİP) bileşeni hedef olmayan yeni uyaranlara karşı ortaya çıkan bir N2-P3a kompleksidir. Bu çalışmamızda, yeniliğin saptanmasında daha belirleyici olan OİP bileşenini tespit etmeyi amaçladık. Gereç ve Yöntem: Çalışmamıza gönüllü olarak katılan 10 sağlıklı denekten, uluslar arası 10/20 sistemine göre yerleştirilen 9 elektrod bölgesinden görsel OİP kaydı aldık. Değişken uyaranların çeldirici hedef olmayan uyaran olarak değil hedef olarak tanımlandığı yeni bir deneysel paradigma kullandık ve bu paradigmada değişken hedeflerle oluşan OİP’leri yenilik paradigmasındaki hedef olmayan değişken uyaranlara ve sabit hedef uyaranlara karşı elde edilen OİP’lerle karşılaştırdık. Bulgular: Elde ettiğimiz veriler P3 potansiyelinin hem uyaranların değişkenliğinden hem de hedef olup olmamasından etkilendiğini göstermektedir. Buna karşın, değişken hedeflerle elde edilen N2 potansiyeli ise değişken çeldiricilerle elde edilenden farksız, sabit hedeflerle elde edilenden anlamlı derecede daha büyük genlikli bulunmuştur.Sonuç: Hem değişken hedef hem de değişken çeldirici uyaranlara karşı oluşan büyük genlikli N2 dalgası gerçek anlamda uyaranların yeniliğini gösteren OİP bileşenidir.

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Cite This Article

REŞİTOĞLU, B., ERGEN, M., USLU, A., ERGENOĞLU, T., BEYDAĞI, H., DEMİRALP, T. (2022). The N2 wave of event-related potentials reflects the novelty of the eliciting stimuli. Erciyes Tıp Dergisi, Cilt: 28 - Sayı: 2, 49–56. https://ajindex.com/articles/502790

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