Journals / Erciyes Tıp Dergisi / 2006 / Cilt: 28 - Sayı: 4

Effect of oxidative stress on erythrocyte deformability in Behçet’s disease

Behçet hastalığı'nda artan oksidatif stresin eritrosit deformabilitesi üzerine etkisi

Pages
197–204
Publication Date
2022-10-17
DOI
—
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Antioxidant enzymes and MDA levels were measured spectrophotometrically and erythrocyte deformability indexes were measured by filtration method.Results: When compared to healthy controls, antioxidant enzyme levels changed and MDA levels increased and erythrocyte deformability indexes impaired in Behçet’s disease particularly in the active period compared to inactive subjects (p

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: Behçet’s disease is a multisystemic disease that effects almost every organ in the body.
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Key Findings & Data:It is known that oxidative stress levels increase in Behçet’s disease.
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Conclusion & Impact:Antioxidant enzymes and MDA levels were measured spectrophotometrically and erythrocyte deformability indexes were measured by filtration method.Results: When compared to healthy controls, antioxidant enzyme levels changed and MDA levels increased and erythrocyte deformability indexes impaired in Behçet’s disease particularly in the active period compared to inactive subjects (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: Behçet’s disease is a multisystemic disease that effects almost every organ in the body. It is known that oxidative stress levels increase in Behçet’s disease. The increase in oxidative stress may impair erythrocyte deformability. In this study we measured antioxidant enzymes and MDA levels as an indicator of oxidative stress and erythrocyte deformability indexes.Material and Methods: Blood samples were taken from 2 patient groups consisting of 16 patients in active period and 17 patients in remission period. Blood samples taken from a control group consisting of 15 healthy volunteers were used. The patients and the controls were not statistically different in regard to age, gender and smoking rates. Antioxidant enzymes and MDA levels were measured spectrophotometrically and erythrocyte deformability indexes were measured by filtration method.Results: When compared to healthy controls, antioxidant enzyme levels changed and MDA levels increased and erythrocyte deformability indexes impaired in Behçet’s disease particularly in the active period compared to inactive subjects (p

Özet

Amaç: Multisistemik bir hastalık olan Behçet hastalığında, vücuttaki bütün organlar etkilenmekte ve oksidatif stresin arttığı bilinmektedir. Artan oksidatif stres nedeniyle, eritrosit deformablite özelliklerinin değişmesi mümkündür. Bu çalışmada, Behçet hastalarında artan oksidatif stresin göstergesi olarak antioksidan enzim ve MDA düzeyleri ile değişikliklerin eritrositler üzerindeki etkisini görebilmek amacıyla da eritrosit deformabilitesi ölçülmüştür.Gereç ve Yöntem: Çalışmada, 16’sı aktif, 17’si remisyon döneminde olan 2 hasta grubuyla 15 sağlıklı bireyden oluşan, yaş, cinsiyet ve sigara içimi açısından hasta gruplarıyla eşleşen kontrol grubu bireylerinden alınan kan örnekleri kullanılmıştır. Antioksidan enzimler ve MDA düzeyleri spektrofotometrik olarak, deformabilite ise filtrasyon yöntemiyle ölçülmüştür.Bulgular: Behçet hastalarında, antioksidan enzim düzeylerinin değiştiği, MDA düzeylerinin arttığı ve eritrositlerin deformabilite özelliklerinin bozulduğu gözlenmiştir. Bu değişikliklerin, aktif hasta grubunda, remisyondaki hastalara göre belirgin olarak değiştiği görülmüştür(p

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Cite This Article

AŞÇIOĞLU, Ö., AYDOĞAN, S., YAPIŞLAR, H. (2022). Effect of oxidative stress on erythrocyte deformability in Behçet’s disease. Erciyes Tıp Dergisi, Cilt: 28 - Sayı: 4, 197–204. https://ajindex.com/articles/502785

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