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Journals / Erciyes Tıp Dergisi / 2007 / Cilt: 29 - Sayı: 2

The effects of taurine, melatonin and acetylcysteine on nitric oxide, lipid peroxidation and some antioxidants in cadmium induced liver injury

Kadmiyuma bağlı karaciğer hasarında taurin,melatonin ve asetilsisteinin nitrik oksit, lipid peroksidasyonu ve bazı antioksidanlar üzerindeki etkileri

Nurettin AYDOĞDU
Hakan ERBAŞ
Mehmet KANTER
Kadir KAYMAK
Pages
89–96
Publication Date
2022-10-17
DOI
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Conclusion: Taurine, melatonin and acetylcysteine may have both protective and therapeutic effects in cadmium induced liver injuries

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Objective & Hypothesis:Purpose: Our aim was to investigate both the potential protective and therapeutic effects of taurine, melatonin and acetylcysteine in cadmium induced liver injury.Material and Methods: Ninety male Spraque Dawley rats were divided into nine groups.
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Key Findings & Data:For the three months treatment period, drinking water was administered to Group 1 whereas 200 ppm CdCl2 to Group 2, 200 ppm CdCl2 and 1% taurine to Group 3, 200 ppm CdCl2 and 0.02% melatonin to Group 4 and 200 ppm CdCl2 and 0.5%acetylcysteine to Group 5.
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Conclusion & Impact:Conclusion: Taurine, melatonin and acetylcysteine may have both protective and therapeutic effects in cadmium induced liver injuries
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: Our aim was to investigate both the potential protective and therapeutic effects of taurine, melatonin and acetylcysteine in cadmium induced liver injury.Material and Methods: Ninety male Spraque Dawley rats were divided into nine groups. For the three months treatment period, drinking water was administered to Group 1 whereas 200 ppm CdCl2 to Group 2, 200 ppm CdCl2 and 1% taurine to Group 3, 200 ppm CdCl2 and 0.02% melatonin to Group 4 and 200 ppm CdCl2 and 0.5%acetylcysteine to Group 5. Groups 6, 7, 8 and 9 received 200 ppm CdCl2 in their drinking water for 3 months. After this period, for 7 days, 4% taurine to group 7, 0.08% melatonin to Group 8 and 2% acetylcysteine to group 9 were applied. Results: In liver tissues of cadmium received rats, the levels of glutathione (GSH) and the enzyme activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were decreased. Thiobarbituric acid reactive substances (TBARS), nitric oxide (NO) and inducible nitric oxide synthase (iNOS) activities were increased. While, taurine, melatonin and acetylcysteine increased GSH levels, SOD and GPx activities, it decreased TBARS, NO and iNOS activities. Conclusion: Taurine, melatonin and acetylcysteine may have both protective and therapeutic effects in cadmium induced liver injuries

Özet

Amaç:Kadmiyumun oluşturduğu karaciğer hasarını karşı taurin, melatonin ve asetilsisteinin hem koruyucu hem de tedavi etkilerini karşılaştırmayı amaçladık. Gereç ve Yöntem: Çalışmamızda 90 adet erkek Spraque Dawley sıçan 9 gruba ayrıldı. 3 ay süreyle grup 1’e içme suyu, grup 2’ye 200 ppm CdCl2, grup 3’e 200 ppm CdCl2 ve % 1 taurin, grup 4’e 200 ppm CdCl2 ve % 0,02 melatonin, grup 5’e 200 ppm CdCl2 ve % 0,5 asetilsistein içme sularına katıldı. Grup 6, 7, 8 ve 9’un içme sularına 3 ay süreyle 200 ppm CdCl2 katıldıktan sonra 7 gün, 7. gruba % 4 taurin, 8. gruba % 0,08 melatonin ve 9. gruba % 2 asetilsistein içme sularına katıldı. Bulgular: Sadece kadmiyum verilen grupların karaciğer dokusunda glutatyon (GSH) düzeyinin, süperoksit dismutaz (SOD), ve glutatyon peroksidaz (GPx) enzim aktivitelerinin azaldığı; Tiyobarbitürik asit reaktif ürünleri (TBARS), nitrik oksit (NO), immünohistokimyasal olarak indüklenebilir nitrik oksit sentaz (iNOS) pozitif hücrelerin arttığı görüldü. Taurin, melatonin ve asetilsistein verilen gruplarda GSH düzeyinin, SOD ve GPx aktivitelerinin arttığı; TBARS, NO düzeylerinin ve iNOS aktivitelerinin azaldığı saptandı. Sonuç: Taurin, melatonin ve asetilsisteinin kadmiyuma bağlı olarak gelişen karaciğer hasarına karşı hem koruyucu hem de tedavi edici rol oynadığı görüldü.

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Cite This Article

AYDOĞDU, N., ERBAŞ, H., KANTER, M., KAYMAK, K. (2022). The effects of taurine, melatonin and acetylcysteine on nitric oxide, lipid peroxidation and some antioxidants in cadmium induced liver injury. Erciyes Tıp Dergisi, Cilt: 29 - Sayı: 2, 89–96. https://ajindex.com/articles/502724

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