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Journals / Erciyes Tıp Dergisi / 2008 / Cilt: 30 - Sayı: 3

Lipid peroxidation and antioxidant enzyme activity in acute leukemias

Akut lösemilerde lipid peroksidasyonu ve antioksidan enzim aktivitesi

Mehmet BERKÖZ
Atilla YALÇIN
Volkan Güneş GÜLER
Serap YALIN
Pages
157–162
Publication Date
2022-10-17
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Data obtained for each group were analyzed statistically using SPSS-10 software and groups were compared employing Mann-Whitney U Test.Results: The MDA levels in acute leukemia patients have been found to be increased, but the catalase levels found to be significantly decreased compared to controls.Conclusion: Our findings indicate that acute leukemia has increased the free radical and decreased antioxidant levels and as a result free radical-antioxidant balance has been impaired.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: The aim of our study is the investigation of possible changes in free radical-antioxidant balance in acute leukemias.
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Key Findings & Data:Material and Methods: In this study, we have investigated 21 acute leukemia patients and 22 healthy volunteers for the control group.
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Conclusion & Impact:Data obtained for each group were analyzed statistically using SPSS-10 software and groups were compared employing Mann-Whitney U Test.Results: The MDA levels in acute leukemia patients have been found to be increased, but the catalase levels found to be significantly decreased compared to controls.Conclusion: Our findings indicate that acute leukemia has increased the free radical and decreased antioxidant levels and as a result free radical-antioxidant balance has been impaired.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: The aim of our study is the investigation of possible changes in free radical-antioxidant balance in acute leukemias. Material and Methods: In this study, we have investigated 21 acute leukemia patients and 22 healthy volunteers for the control group. Among the acute leukemia patients; 10 of them as AML (Acute Myeloid Leukemia), 8 of them as ALL (Acute Lymphocytic Leukemia), and 3 of them have been diagnosed as MDS (myelodysplastic syndrome). Catalase activity for the antioxidant property and MDA (malondialdehyde) concentration for the free radical level of all collected blood samples were analyzed. Data obtained for each group were analyzed statistically using SPSS-10 software and groups were compared employing Mann-Whitney U Test.Results: The MDA levels in acute leukemia patients have been found to be increased, but the catalase levels found to be significantly decreased compared to controls.Conclusion: Our findings indicate that acute leukemia has increased the free radical and decreased antioxidant levels and as a result free radical-antioxidant balance has been impaired.

Özet

Amaç: Çalışmamızın amacı akut lösemide serbest radikal-antioksidan dengesinin olası değişikliklerini araştırmaktadır. Gereç ve Yöntem: Bu çalışmaya 21 akut lösemi hastası ve 22 sağlıklı gönüllü dahil edilmiştir. Akut lösemi hastalarının 10'u Akut Myeloid Lösemi, 8'i Akut Lenfositik Lösemi ve 3'ü Myelodisplastik Sendrom tanısı aldı. Toplanan kan örneklerinde serum antioksidan özelliği için katalaz aktivitesi ve serbest radikal düzeyleri için serum malondialdehit, (MDA) seviyesi ölçüldü. Gruplar Mann-Whitney U testi ile karşılaştırıldı.Bulgular: MDA seviyesinin akut lösemili hastalarda arttığı ancak katalaz aktivitesinin anlamlı ölçüde azaldığı belirlendi.Sonuç: Bulgularımız, akut lösemilerde tümör hücrelerinin oluşturduğu serbest radikallerin lipid peroksidasyonunu arttırdığı ve artmış lipid peroksidasyonunun antioksidan sistemi zayıflattığını düşündürmektedir.

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Cite This Article

BERKÖZ, M., YALÇIN, A., GÜLER, V. G., YALIN, S. (2022). Lipid peroxidation and antioxidant enzyme activity in acute leukemias. Erciyes Tıp Dergisi, Cilt: 30 - Sayı: 3, 157–162. https://ajindex.com/articles/502658

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