AI Summary & Key Takeaways
AI InsightDuring the operation, hemodynamic parameters, neuromuscular function, BIS and total amount of desflurane were recorded.Results: Total desflurane consumptions (Group A: 50.12±15 ml, Group B: 80.26±13.7 ml, Group C:92.19±25.1 ml), additional dose of fentanyl and the onset time of rocuronium in Group A were statistical difference lower than other groups.Conclusion: It was concluded that administration of dexmedetomidine as a bolus of 1µ Kg-1 and as an infusion dose of 0.5 µ kg-1 h-1 decreases the onset time of rocuronium, and decreases desflurane consumption by 45% in accordance with the control group, and reduces intraoperative requirement for additional analgesic dose.
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Abstract
Purpose: The effects of two different doses of dexmedetomidine, a selective α2-receptor agonist, on anesthetic agent consumption and neuromuscular blockade and intraoperative analgesic requirement were aimed to compare with the control group.Material and methods: Sixty patients between 18 and 60 ages were studied. Three groups were made, dexmedetomidine infusion was begun for Group A and Group B, 1 µg kg-1 and 0.5 µg kg-1 respectively and Group C were infused serum physiologic. After the standard anesthesia induction, dexmedetomidine infusion was begun for Group A and Group B, 0.5 µg kg-1 h-1 and 0.25 µg kg-1 h-1 respectively and Goup C were infused serum physiologic. During the operation, hemodynamic parameters, neuromuscular function, BIS and total amount of desflurane were recorded.Results: Total desflurane consumptions (Group A: 50.12±15 ml, Group B: 80.26±13.7 ml, Group C:92.19±25.1 ml), additional dose of fentanyl and the onset time of rocuronium in Group A were statistical difference lower than other groups.Conclusion: It was concluded that administration of dexmedetomidine as a bolus of 1µ Kg-1 and as an infusion dose of 0.5 µ kg-1 h-1 decreases the onset time of rocuronium, and decreases desflurane consumption by 45% in accordance with the control group, and reduces intraoperative requirement for additional analgesic dose.
Özet
Amaç: Selektif α2-reseptör agonisti deksmedetomidinin farklı iki dozunun, anestezik ajan tüketimi, kas gevşemesi ve intraoperatif analjezik gereksinimi üzerine olan etkilerinin kontrol grubuyla karşılaştırılması amaçlanmıştır.Gereç ve Yöntem: Çalışmaya 18-60 yaş arası 60 olgu dahil edildi. Üç gruba ayrılarak Grup A'ya 1 µg kg-1, Grup B'ye 0,5 µg kg-1 deksmedetomidin, Grup C'ye ise serum fizyolojik infüzyonu başlandı. Standart anestezi indüksiyonu sonrası Grup A'ya 0,5 µg kg-1 sa-1, Grup B'ye 0,25 µg kg-1 sa-1 deksmedetomidin, Grup C ‘ye ise serum fizyolojik infüzyonu başlandı. Operasyon süresince hemodinamik parametreler, nöromusküler fonksiyon, bispektrolindeks ve desfluran miktarı kaydedildi.Bulgular: Toplam desfluran tüketimi (Grup A'da: 50,12±15 ml, Grup B'de: 80,26±13,7 ml, Grup C'de: 92,19±25,1 ml), operasyon sırasındaki ek doz fentanil gereksinimi ve rokuronyum etki başlama süresi (1,13±0,23 dk) Grup A'da istatistiksel olarak düşük bulundu.Sonuç: Deksmedetomidin 1 µg kg-1 bolus ve 0.5µg kg-1sa-1 infüzyon dozunun, rokuronyumun etki başlama süresini kısalttığı, kontrol grubuna göre desfluran tüketimini yaklaşık % 45 azalttığı ve operasyon sırasındaki ek doz analjezik gereksinimini düşürdüğü sonucuna varıldı.