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Journals / Erciyes Tıp Dergisi / 2009 / Cilt: 31 - Sayı: 4

Evaluation of the sustained damage in brain and heart tissues of rats following inhalation of chlorine gas and the efficiency of N-acetylcysteine

Klor gazı solutulan ratların beyin ve kalp dokusunda oluşan hasarın incelenmesi ve N-asetilsistein'in etkinliği

Seda ÖZKAN
Sabahattin MUHTAROĞLU
İbrahim İKİZCELİ
Levent AVŞAROĞULLARI
Polat DURUKAN
Okhan AKDUR
Erdoğan M. SÖZÜER
Figen ÖZTÜRK
Pages
293–298
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Histologically, N-acetylcysteine was observed to repair the damage in brain tissue which occurred at the 24th hour (p

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Objective & Hypothesis:Purpose: Determination of the sustained damage in brain and heart tissues of rats due to exposure to chlorine gas inhalation and investigation of the role of N-acetylcysteine over that damage.Material and Methods: A total of 50 rats were split into 5 groups all of which contained 10 rats.
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Key Findings & Data:No treatment was applied to the Group 1.
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Conclusion & Impact:Histologically, N-acetylcysteine was observed to repair the damage in brain tissue which occurred at the 24th hour (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: Determination of the sustained damage in brain and heart tissues of rats due to exposure to chlorine gas inhalation and investigation of the role of N-acetylcysteine over that damage.Material and Methods: A total of 50 rats were split into 5 groups all of which contained 10 rats. No treatment was applied to the Group 1. Group 2 and 3 consisted 6th hour control and N-acetylcysteine groups, respectively; whereas Group 4 and 5 were enrolled as the 24th hour control and N-acetylcysteine groups, respectively. Rats were subjected to inhalation of 200 ppm chlorine gas for 20 minutes. Following chlorine gas inhalation, intraperitoneal 40 mg/kg N-acetylcysteine was administered to N-acetylcysteine groups. Same dose of N-acetylcysteine was given again 3 hours later via the same route.Results: While there was no damage in the brain tissue at the 6th hour (p>0.05), there was a damage at the 24th hour (p0.05). Histologically, N-acetylcysteine was observed to repair the damage in brain tissue which occurred at the 24th hour (p

Özet

Amaç: Bu çalışmada klor gazı solutulan ratların, beyin ve kalp dokusunda oluşan hasarı tespit etmek ve bu hasar üzerine N-asetilsistein'in etkinliğini araştırmak amaçlanmıştır.Gereç ve Yöntemler: Elli rat 10'arlı 5 gruba ayrıldı. Grup 1'e hiçbir şey verilmedi. Grup 2 ve grup 3, sırası ile 6. saat kontrol ve N-asetilsistein grubu, grup 4 ve grup 5, sırası ile 24. saat kontrol ve N-asetilsistein grubu olarak alındılar. Ratlara 20 dakika süreyle 200 ppm klor gazı solutuldu. N-asetilsistein gruplarına klor gazı verildikten sonra intraperitoneal olarak 40 mg/kg N-asetilsistein uygulandı. Aynı doz N-asetilsistein 3 saat sonra aynı yol ile tekrar verildi.Bulgular: Beyin dokusunda 6. saatte herhangi bir hasar tespit edilmez iken (p>0,05) 24. saatte hasar gözlendi (p0,05). Histopatolojik olarak N-asetilsistein'in 24. saatte beyin dokusunda oluşan hasarı düzelttiği görüldü (p

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Cite This Article

ÖZKAN, S., MUHTAROĞLU, S., İKİZCELİ, İ., AVŞAROĞULLARI, L., DURUKAN, P., AKDUR, O., SÖZÜER, E. M., ÖZTÜRK, F. (2022). Evaluation of the sustained damage in brain and heart tissues of rats following inhalation of chlorine gas and the efficiency of N-acetylcysteine. Erciyes Tıp Dergisi, Cilt: 31 - Sayı: 4, 293–298. https://ajindex.com/articles/502595

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