Journals / Erciyes Tıp Dergisi / 2010 / Cilt: 32 - Sayı: 3

Behçet's disease and left ventricular diastolic function abnormalities

Behçet hastalığı ve sol ventrikül diyastolik fonksiyon bozukluğu

Pages
171–176
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

For this reason, left ventricular diastolic functions should be evaluated with echocardiography in Behçet's disease.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: This study aimed to assess left ventricular (LV) diastolic function with conventional doppler echocardiography (DE) and tissue doppler imaging (TDI), in the diagnosis of Behçet's disease.Material and Methods: 35 patients with Behçet's disease were included in this study.
📊
Key Findings & Data:The following measurement was derived from the mitral annular velocity by TDI: Early diastolic (Em), late diastolic (Lm) velocities, Em/Lm and E/Em ratios.Results: Mean age of the patients was 38±10.8.
💡
Conclusion & Impact:For this reason, left ventricular diastolic functions should be evaluated with echocardiography in Behçet's disease.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: This study aimed to assess left ventricular (LV) diastolic function with conventional doppler echocardiography (DE) and tissue doppler imaging (TDI), in the diagnosis of Behçet's disease.Material and Methods: 35 patients with Behçet's disease were included in this study. All patients were evaluated by M-mode, two-dimensional conventional DE, as well as by TDI. The following conventional doppler parameters were measured: Peak early diastolic (E) and late diastolic (L) flow velocity, E/A ratio, early diastole flow velocity deceleration time (DT), and isovolumetric relaxation time (IVRT). The following measurement was derived from the mitral annular velocity by TDI: Early diastolic (Em), late diastolic (Lm) velocities, Em/Lm and E/Em ratios.Results: Mean age of the patients was 38±10.8. Study group consisted of 20 male (57.1%) and 15 female patients (42.9%). Mean body mass index was compatible with overweight (26.8±4.9). Mean systolic blood pressure was 123.4±11.9 and diastolic blood pressure was 79.8±9.5. Left ventricular systolic dysfunction and severe valvular disease was not present in any patient. Left ventricular end-diastolic, end-systolic diameter, left atrium diameter and aortic root diameter were within normal ranges. Diastolic dysfunction was present in 9 of 35 patients (% 25.7) with Behçet's disease.Conclusion: Left diastolic dysfunction is more prevalent in patients with Behçet's disease without cardiac signs and symptoms. These findings support subclinical myocardial deformation. For this reason, left ventricular diastolic functions should be evaluated with echocardiography in Behçet's disease.

Özet

Amaç: Bu çalışma Behçet hastalarında sol ventrikül (LV) diyastolik fonksiyonlarını konvansiyonel doppler ekokardiyografi ve doku doppler görüntülemesi (DDG) ile değerlendirmeyi amaçladık.Gereç ve Yöntem: Çalışmaya 35 Behçet hastası alındı. Tüm hastalar M-mod, 2 boyutlu, konvansiyonel doppler ekokardiyografi ve doku doppler görüntüleme yöntemi ile değerlendirildi. Konvansiyonel doppler parametrelerinden pik erken diyastolik (E) ve geç diyastolik (A) akım velositeleri, E/A orana, erken diyastolik akım velositesinin deselerasyon zamanı (DZ) ve izovolumetrik gevşeme zamanı (IVRT) ölçüldü. Daha sonra DDG ile mitral annular erken diyastolik (Em) ve geç diyastolik (Am) velositeleri kayıtları alındı ve buradan da Em/Em oranları hesaplandı.Bulgular: Hastaların yaş ortalaması 38±10.8 idi. Hastaların 20'si (% 57,1) erkek, 15(% 42,9) bayan idi. Vücut kitle indeksleri fazla kilolu (26,8±4.9) statüsünde; kalp atım hızları normokardik (78,4±9,6) idi. Hastaların ortalama sistolik kan basıncı 123,4±11,9, diyastolik kan basıncı 79,8±9,5 idi. Hastalara yapılan ekokardiyografik incelemede hiçbir hastada sistolik fonksiyon bozukluğu ve ciddi kapak hastalığı izlenmedi. Hastaların ventrikül çapları, sol atriyum, aort kökü genişlikleri normal sınırlar içindeydi. Hastalar genel olarak değerlendirildiğinde 35 Behçet hastasının 9(% 25,7)‘unda diyastolik disfonksiyon tespit edildi.Sonuç: Kardiyak semptom ve bulguları olmayan Behçet hastalarında LV diyastolik fonksiyon bozukluğunun fazla olduğu görülmüştür. Bu da subklinik miyokard tutulumunu desteklemektedir. Bu nedenle Behçet hastalarında ekokardiyografik değerlendirme ile LV diyastolik fonksiyonlarının detaylı değerlendirilmesi gerekmektedir.

🔖

Cite This Article

KULLUK, P., ŞARLI, B., DOĞRU, O., KAYA, M. G., GÜNEBAKMAZ, Ö., OĞUZHAN, A., BORLU, M., AKKAYA, H. (2022). Behçet's disease and left ventricular diastolic function abnormalities. Erciyes Tıp Dergisi, Cilt: 32 - Sayı: 3, 171–176. https://ajindex.com/articles/502574

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Behçet H. Uber rezidivierende aphthose durch ein virus- veursachte geschwur am mund, am auge und an den genitalien. Dermatol Monatsschr 1937; 105: 1152-1157
  2. Lee S, Bang D, Lee ES, et al. Behçet's Disease: A Guide to Its Clinical Understanding: Textbook and Atlas. Heidelberg, Germany: Springer-Verlag; 2001. p.11-13
  3. Schimuzu T, Erlich GE, Inaba G, Hayashi K. Behçet's disease (Behçet's syndrome). Semin Arthrits Rheum 1979; 8: 223-260
  4. Zabel M, Portnoy S, Franz MR. Electrocardiographic indexes of dispersion of ventricular repolarization: an isolated heart validation study. J Am Coll Cardiol 1995; 25:746-752
  5. Niwa Y, Miyake S, Sakane T, Shingu M, Yokoyama M. Auto-oxidative damage in Behçet's disease – endothelial cell damage following the elevated oxygen radicals generated by stimulated neutrophils. Clin Exp Immunol 1982; 49: 247-255
  6. Calguneri M, Erbas B, Kes S, Karaaslan Y. Alterations in left ventricular function in-patients with Behçet's disease using radionuclide ventriculography and Doppler echocardiography. Cardiology 1993; 82:309-316
  7. Koç Y, Güllü I, Akpek G, et al. Vascular involvement in Behçet's disease. J Rheumatol 1992; 19: 402-410
  8. Mandinov L, Eberli FR, Seiler C, Hess OM. Diastolic heart failure. Cardiovasc Res 2000; 45:813-825
  9. Nishimura RA, Tajik AJ. Evaluation of diastolic filling of left ventricle in health and disease: Doppler echocardiography is the clinician's Rosetta Stone. J Am Coll Cardiol. 1997; 30:8-18
  10. Choong CY, Herrmann HC, Weyman AE, Fifer MA. Preload dependence of Doppler-derived indexes of left ventricular diastolic function in humans. J Am Coll Cardiol 1987;10:800-808
  11. Garcia MJ, Thomas JD, Klein AL. New doppler echocardiographic applications for the study of diastolic function. J Am Coll Cardiol 1998; 32: 865-875
  12. Lindstrom L, Wranne B. Pulsed tissue dopler evaluation of mitral annulus motion; A new window to assessment of diastolic function. Clin Phsiol 1999; 19:1-10
  13. Chajek T, Fainaru M. Behçet's Disease. Report of 41 cases an a review of the literature. Medicine (Baltimore) 1975; 54:179-196
  14. Vanhaleweyk G, el-Ramahi KM, Hazmi M, Sieck JO, Zaman L, Fawzy M. Right atrial, right ventricular and left ventricular thrombi in (incomplete) Behçet's disease. Eur Heart J 1990;11:957-959
  15. Candan I, Deger N, Erol N, Gurler A. Left Ventricular functions in Behçet's disease. Turkish Cardiol Clin Behçet Suppl 1985; 2:427-431
  16. Shen LL, Cui GG, Liang RL. Valve prolapse in Behçet's dis