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Journals / Erciyes Tıp Dergisi / 2012 / Cilt: 34 - Sayı: 4

Allojenik hematopoetik kök hücre nakli yapılan hastalarda sağkalım üzerine etkisi olan faktörlerin değerlendirilmesi

Factors that affect survival in patients with allogeneic hematopoetic stem cell transplantation

Fevzi ALTUNTAŞ
Leylagül KAYNAR
Cem ŞAHİN
Bülent ESER
Serdar ŞIVGIN
Ali ÜNAL
Mustafa ÇEtİN
Fatih KURNAZ
Çiğdem PALA
Pages
178–183
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: When confounding factors of transplant-related mortality were assessed using multivariate regression analysis, recurrent disease development was shown to be the most significant factor affecting mortality (hazard rate: 3.12; 95% CI: 2.02-4.82; p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: It was aimed to evaluate factors contributing to mortality in the post-transplantation period and determine the relative risk of death caused by these factors in patients who underwent allogeneic hematopoietic stem cell transplantation.
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Key Findings & Data:Material and Methods: Outcomes of 184 patients who underwent stem cell transplantation were retrospectively assessed.
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Conclusion & Impact:Results: When confounding factors of transplant-related mortality were assessed using multivariate regression analysis, recurrent disease development was shown to be the most significant factor affecting mortality (hazard rate: 3.12; 95% CI: 2.02-4.82; p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: It was aimed to evaluate factors contributing to mortality in the post-transplantation period and determine the relative risk of death caused by these factors in patients who underwent allogeneic hematopoietic stem cell transplantation. Material and Methods: Outcomes of 184 patients who underwent stem cell transplantation were retrospectively assessed. The patients were classified by considering the factors such as diagnosis, health status at the time of transplantation, time of transplantation, time between diagnosis and transplantation, histocompatibility, donor-recipient gender compatibility, amount of CD34 stem cell which was given, preparation regimes and risk status at the time of diagnosis. Outcomes were analyzed statistically by Kaplan-Meier survival analysis, Cox regresion test and multivariate regresion test. Results: When confounding factors of transplant-related mortality were assessed using multivariate regression analysis, recurrent disease development was shown to be the most significant factor affecting mortality (hazard rate: 3.12; 95% CI: 2.02-4.82; p

Özet

Amaç: Allojenik hematopoetik kök hücre nakli yapılan hastalarda nakil başarısını etkileyebilecek faktörlerin sağkalım üzerine etkisinin belirlenmesi amaçlanmaktadır. Gereç ve Yöntemler: Kök hücre nakli yapılan 184 hastanın verileri geriye dönük olarak değerlendirildi. Hastalar tanı, nakil anındaki hastalık durumu, nakil zamanı, tanı ile nakil arasında geçen süre, doku uyumu, alıcı verici arasındaki cinsiyet uyumu, nakil sırasında verilen CD34 kök hücre miktarı, uygulanan hazırlık rejimleri ve akut lösemili hastalar için tanı anındaki risk durumlarına göre gruplara ayrıldı. Gruplar arasındaki sağkalım oranları Kaplan-Meier survival analiz yöntemiyle hesaplanırken mortaliteye etki eden faktörlerin belirlenmesi ve göreceli risk tayininde cox regresyon testi ile çoklu değişkenli regresyon analizleri kullanıldı. Bulgular: Çoklu değişkenli regresyon analizi sonucunda mortalite gelişimi üzerine en etkili faktörün nüks hastalık gelişimi olduğu gösterildi (risk oranı: 3,12; %95 CI: 2,02-4,82; p

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Cite This Article

ALTUNTAŞ, F., KAYNAR, L., ŞAHİN, C., ESER, B., ŞIVGIN, S., ÜNAL, A., ÇEtİN, M., KURNAZ, F., PALA, Ç. (2022). Allojenik hematopoetik kök hücre nakli yapılan hastalarda sağkalım üzerine etkisi olan faktörlerin değerlendirilmesi. Erciyes Tıp Dergisi, Cilt: 34 - Sayı: 4, 178–183. https://ajindex.com/articles/502471

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